1. Jimmy Garoppolo, QB (San Francisco 49ers)
As someone who wasn’t drafted as a starting QB in a 12-team league, Jimmy Garoppolo enters Week 1 with a juicy matchup against the Arizona Cardinals. While AZ did address its defense through the draft, they’re still one of the weaker ones in the league. Last season, Jimmy G was able to throw for 741 yards, 8 touchdowns, and 2 interceptions in his two games against the Cardinals. San Francisco enters as a 7-point home favorite and the offense should continue where it left off from last season. Expect Garoppolo to exceed 18 fantasy points and score more than QBs like Kirk Cousins and Matthew Stafford this week.