Who Should I Start? Christian McCaffrey or Cooper Kupp

Saturday, December 20, 6:03 AM

San Francisco 49ers running back Christian McCaffrey will put a four-game touchdown streak on the line in Week 16 against the Colts. Last week, Indianapolis held Seahawks running backs Kenneth Walker III and Zach Charbonnet out of the end zone, but had given up at least one rushing touchdown to a running back in each of their six previous games. McCaffrey appears to be clear of the back injury that made him a surprising late addition to the 49ers' injury report last week, and should see plenty of work on Monday night. If Ricky Pearsall (knee/ankle) is unable to play, then CMC would likely reemerge as a candidate to lead the team in targets, as he has done six times already in 2025. Fantasy football managers should watch for the 49ers' final injury report, but assuming McCaffrey is fully healthy, he has the potential for a top-3 finish at his position.

Wednesday, December 17, 10:48 PM

Seattle Seahawks wide receiver Cooper Kupp will enter his second matchup against his former team, the Los Angeles Rams, in Week 16. The Rams are 24th against opposing wide receivers in fantasy, but Kupp's volume has been so low for most of the season that he has been very inconsistent for fantasy. Kupp recorded five receptions on seven targets in Week 15. However, Kupp's seven targets marked just the fifth time he had exceeded four targets in a game all season. With fellow wide receiver Rashid Shaheed's role with this offense growing, and tight end AJ Barner playing a factor, it is difficult to predict another seven-plus target game for Kupp. Kupp is a bench option for now in case his role is increasing down the stretch of the season, but he is a very risky starting option in Week 16.