Who Should I Start? Christian McCaffrey or George Pickens

Saturday, December 20, 6:03 AM

San Francisco 49ers running back Christian McCaffrey will put a four-game touchdown streak on the line in Week 16 against the Colts. Last week, Indianapolis held Seahawks running backs Kenneth Walker III and Zach Charbonnet out of the end zone, but had given up at least one rushing touchdown to a running back in each of their six previous games. McCaffrey appears to be clear of the back injury that made him a surprising late addition to the 49ers' injury report last week, and should see plenty of work on Monday night. If Ricky Pearsall (knee/ankle) is unable to play, then CMC would likely reemerge as a candidate to lead the team in targets, as he has done six times already in 2025. Fantasy football managers should watch for the 49ers' final injury report, but assuming McCaffrey is fully healthy, he has the potential for a top-3 finish at his position.

Sunday, December 21, 6:49 PM

Dallas Cowboys wide receiver George Pickens bounced back with a massive performance during Sunday's contest against the Los Angeles Chargers. Before this game, Pickens was held to under 40 receiving yards in each of his last two contests. Pickens rebounded with a massive performance against the Chargers' defense in Week 16. He hauled in seven of his nine targets for 103 yards and a touchdown in the loss. This marked the fifth time this season that Pickens has surpassed 100 yards in a single game. The 24-year-old has been elite with 88 receptions, 1,342 yards, and nine touchdowns heading into the Week 17 matchup against the Washington Commanders.