Who Should I Start? Christian McCaffrey or Joe Mixon

Friday, October 3, 12:32 AM

San Francisco 49ers running back Christian McCaffrey rushed for 57 yards on 22 carries during Thursday's Week 5 win over the Los Angeles Rams. He also caught eight of his nine targets for 82 receiving yards and a receiving touchdown. The superstar running back handled 30 total touches, continuing to prove that he's the only relevant member of the Niners' backfield for the time being. His efficiency on the ground was a little underwhelming, but that didn't stop him from dominating as a pass catcher, per usual. The 29-year-old has exceeded 22.5 fantasy points (PPR) in every game this season, ranking as the overall RB1 to this point. He should be started with full confidence against the Buccaneers in Week 6.

Tuesday, October 7, 11:41 AM

Houston Texans general manager Nick Caserio said the team will have clarity on running back Joe Mixon's (foot/ankle) health status for the "duration of the year" at some point "over the next few weeks." Mixon has not played yet in 2025, and the team has provided little to no information about a possible return timeline. It seems possible, if not likely, that the 29-year-old will miss the entirety of the season. If that's the case, Houston will likely continue splitting backfield work between veteran Nick Chubb and rookie Woody Marks. Chubb has recorded 58 carries for 249 yards and two touchdowns so far this season. Marks has logged 233 yards from scrimmage and two touchdowns on 42 total touches, and could eventually work his way into the lead role over the course of the season.