Who Should I Start? Christian McCaffrey or Ricky Pearsall

Saturday, November 15, 4:31 AM

San Francisco 49ers running back Christian McCaffrey had his second-lowest rushing total of the season in Week 10, gaining just 30 yards on the ground on 12 carries against the Rams. McCaffrey hasn't been as productive in the run game as he has been in years past, averaging 62.6 rushing yards per game in 2025. Still, McCaffrey has been an invaluable fantasy asset thanks to what he has done as a receiver. The double-threat is second in the NFL in receptions behind only Ja'Marr Chase and sixth in receiving yards. In Week 11, McCaffrey will do plenty of damage against the Arizona Cardinals. Last week, Arizona gave up 181 rushing yards and two touchdowns to the Seahawks' running backs. McCaffrey is a regular contender for overall RB1, and his projection for Week 11 is no different.

Saturday, November 15, 5:11 AM

San Francisco 49ers wide receiver Ricky Pearsall (knee) has no designation on the team's final injury report ahead of their divisional clash with the Arizona Cardinals in Week 11. When San Francisco last faced Arizona, in Week 3, Pearsall had his most productive game of the season, catching eight of 11 targets for 117 receiving yards. Jauan Jennings and George Kittle both missed that game due to injury, making Pearsall the focus of the 49ers' passing attack. With all three pass-catchers now healthy, there will be less work for Pearsall, but he could see better production as the defense won't be able to focus their efforts on any one player. Pearsall's return coincides with that of Brock Purdy (toe), who provides a slight bump to the prospects of San Francisco's skill players. Pearsall projects as a borderline WR3/4 in Week 11 with the upside that comes with being his team's preferred deep threat.