Who Should I Start? Christian McCaffrey or Shedeur Sanders

Saturday, December 20, 6:03 AM

San Francisco 49ers running back Christian McCaffrey will put a four-game touchdown streak on the line in Week 16 against the Colts. Last week, Indianapolis held Seahawks running backs Kenneth Walker III and Zach Charbonnet out of the end zone, but had given up at least one rushing touchdown to a running back in each of their six previous games. McCaffrey appears to be clear of the back injury that made him a surprising late addition to the 49ers' injury report last week, and should see plenty of work on Monday night. If Ricky Pearsall (knee/ankle) is unable to play, then CMC would likely reemerge as a candidate to lead the team in targets, as he has done six times already in 2025. Fantasy football managers should watch for the 49ers' final injury report, but assuming McCaffrey is fully healthy, he has the potential for a top-3 finish at his position.

Sunday, December 21, 4:59 PM

Cleveland Browns rookie quarterback Shedeur Sanders completed 20 of his 29 pass attempts for 157 yards and one touchdown, but threw two interceptions in Sunday's 23-20 loss to the Buffalo Bills. Sanders managed to overcome an injured pinky finger on his throwing hand, which forced him out of the game for a few plays, and completed 69% of his passes, his best passing completion percentage of the year. Most notably, the rookie play caller had four rushes for 49 yards, also a season high. If Sanders continues to gain yards on the ground, which helps to support his fantasy points floor, he may become a more appealing deep league Superflex option. Looking ahead, the Browns will host the Pittsburgh Steelers in Week 17, whose defense gives up the eighth-most fantasy points to opposing quarterbacks for the year.