Who Should I Start? Damien Harris or Brandon Aiyuk

Friday, September 22, 2:24 PM

Running back Damien Harris managed to find the end zone amid Week 2's smackdown of the Las Vegas Raiders for the first touchdown of his Buffalo Bills career. The 26-year-old finds himself in an intimidating matchup on deck against the Washington Commanders' stud nose-tackle combination of Jonathan Allen and Daron Payne. Harris has played behind Latavius Murray for scraps behind lead back James Cook in the opening two weeks, so fantasy managers would really be grasping at straws by inserting Harris into Week 3 lineups. Murray has siphoned five of Buffalo's nine red-zone touches among the three RBs. The power back, Harris, is at least a better bet to hit paydirt than Cook after out-touching him in the red zone 4-0 to this point. Harris probably needs Sunday's meeting to get out of hand in favor of Buffalo to return value as a TD-or-bust RB4/FLEX.

Wednesday, September 27, 6:15 PM

San Francisco 49ers wide receiver Brandon Aiyuk (shoulder) got in a limited practice on Wednesday. The 25-year-old wide receiver suffered a shoulder injury in the first quarter of a Week 2 win over the Los Angeles Rams and sat out Week 3 against the New York Giants as a result. But it's encouraging to see him log a limited practice to start the week, which puts him in line to play on Sunday against the Arizona Cardinals. Both Deebo Samuel (ribs/knee) and Jauan Jennings (shin) both missed practice on Wednesday so if either player, or both, is unable to suit up on Sunday then Aiyuk could be in line for a huge workload.