Who Should I Start? Isaac Guerendo or DJ Giddens

Saturday, September 6, 6:51 AM

Second-year running back Isaac Guerendo opens the season third on the 49ers' depth chart, though he may already see more action than originally anticipated. Christian McCaffrey (calf) popped up on the team's injury report this week and is tagged as questionable for San Francisco's Week 1 matchup against the Seahawks. Guerendo's only route to fantasy relevance relies on CMC sitting. If that does happen, then he can be seen as a deep-league flex candidate. Brian Robinson Jr. will likely draw the start, but Guerendo made his mark in 2024 in similar circumstances and is a potential RB4/5 pending McCaffrey's status.

Wednesday, September 10, 9:29 AM

Indianapolis Colts rookie running back DJ Giddens had a good performance in Week 1 with 41 rushing yards on 12 carries, suitable for a 3.4 YPC. With the Colts up big against the Miami Dolphins, Giddens entered the game to make his NFL debut in the third quarter in place of All-Pro running back Jonathan Taylor. Taylor has been a bit injury-riddled in the past, so if Giddens can continue to impress, it's possible the Colts keep him at the No. 2 running back position over Tyler Goodson (elbow) as the season goes on. The fifth-round rookie was excellent in his final season at Kansas State, and had 205 rushing attempts for 1,343 yards and seven touchdowns, along with 21 receptions for 258 yards and one touchdown, starting all 12 games for Kansas State and earning Second-Team All-Big 12 honors. Giddens is a priority stash with leagues carrying a larger bench, especially for those rostering Taylor. In Week 2, the Colts face a tough home matchup against the Denver Broncos.