Who Should I Start? Joe Mixon or Alvin Kamara

Thursday, November 20, 12:34 PM

Houston Texans running back Joe Mixon (ankle, foot) is not expected to play this season as he deals with a foot injury from the offseason, according to Ian Rapoport of NFL Network. Mixon will likely stay on the Physically Unable to Perform list through the end of the 2025 season, while the Texans move forward with veteran Nick Chubb and rookie Woody Marks in their backfield. Things had been trending this way for a while, as the Texans haven't been giving any real updates on Mixon for pretty much the entire season. Fantasy managers who are still stashing the 29-year-old in redraft leagues should send him to the waiver wire now. Mixon's injury dates all the way back to spring workouts. One would think he'd be ready for the start of the 2026 campaign, but there has been little information about the exact nature of his injury. Marks, a fourth-rounder in April, has slowly started to see more work and should be the backfield leader over Chubb by the end of the year.

Friday, December 5, 2:59 PM

New Orleans Saints running back Alvin Kamara (ankle, knee) has been ruled out for Sunday's Week 14 divisional matchup with the Buccaneers. Kamara was held out of practice with ankle and knee injuries and will now miss his second consecutive game. After a slow start in a Week 13 loss to the Dolphins, sixth-round rookie Devin Neal finished with 47 rushing yards on 14 carries while adding three catches for another 22 yards. He showed good decisiveness and burst, but struggled to find any space behind a banged-up and overmatched offensive line, evidenced by almost 94% of his rushing yardage coming after contact. Tampa Bay has been uncharacteristically soft against the run this season, so Neal remains a low-end RB2/flex play, especially in PPR formats, having earned 10 targets over the past two weeks.