Who Should I Start? Joe Mixon or Alvin Kamara

Thursday, November 20, 12:34 PM

Houston Texans running back Joe Mixon (ankle, foot) is not expected to play this season as he deals with a foot injury from the offseason, according to Ian Rapoport of NFL Network. Mixon will likely stay on the Physically Unable to Perform list through the end of the 2025 season, while the Texans move forward with veteran Nick Chubb and rookie Woody Marks in their backfield. Things had been trending this way for a while, as the Texans haven't been giving any real updates on Mixon for pretty much the entire season. Fantasy managers who are still stashing the 29-year-old in redraft leagues should send him to the waiver wire now. Mixon's injury dates all the way back to spring workouts. One would think he'd be ready for the start of the 2026 campaign, but there has been little information about the exact nature of his injury. Marks, a fourth-rounder in April, has slowly started to see more work and should be the backfield leader over Chubb by the end of the year.

Sunday, November 23, 10:37 PM

New Orleans Saints running back Alvin Kamara's (knee) MRI exam showed an MCL sprain, a source told Nick Underhill of New Orleans Football. Kamara avoided a major injury in Sunday's loss to the Atlanta Falcons in Week 12, but it's unclear if he'll be forced to miss time. It's possible that the 30-year-old misses time, but he is not dealing with a long-term injury. Fantasy managers should expect Kamara to miss at least one game, which means that rookie Devin Neal would be in line for lead-back duties in a strong matchup in Week 13 against the Miami Dolphins. Kamara has been a major disappointment for fantasy managers in 2025 in a struggling Saints offense. He had only three carries for 11 yards and caught both his targets for four yards on Sunday before leaving early. Neal finished with seven carries for 18 yards and caught five of seven targets for 43 yards through the air. Taysom Hill had a team-high 10 carries for 17 yards and will also be much more involved in the backfield for the Saints if Kamara misses time going forward.