Who Should I Start? Joe Mixon or James Cook

Monday, December 29, 1:56 PM

Houston Texans running back Joe Mixon (foot, ankle) will not return this season, league sources told Aaron Wilson of KPRC 2 Sports. The expectation all along has been that Mixon would not return at all in 2025, but now it's official. The Texans haven't released many details on the nature of Mixon's foot/ankle injury, but we know that he hasn't played since back in the spring. The 29-year-old remains on the Non-Football Injury list. At this point, it's fair to wonder if he'll be effective at all if he's able to make it back and play in 2026. The Texans will continue to move forward with rookie Woody Marks as their primary ball-carrier, with veteran Nick Chubb and rookie Jawhar Jordan backing him up heading into the Week 18 regular-season finale against the division-rival Indianapolis Colts.

Tuesday, January 6, 2:27 PM

Buffalo Bills running back James Cook took two carries for 15 yards in an abbreviated appearance in the team's Week 18 win over the Jets. It was enough to keep distance between him and a surging Derrick Henry, with Cook ultimately securing his first regular-season rushing crown with 1,621 yards. Heading into the postseason, he should be viewed as one of the highest upside running backs in fantasy playoff leagues. Buffalo currently holds the fourth-highest Super Bowl odds in a wide-open AFC and is a slight road favorite over a 13-4 Jacksonville team that has been a headache for fantasy running backs throughout most of the season. Despite the tough matchup, Cook is RotoBaller's RB2 for the week, and he could be in line for a massive postseason if Buffalo can advance.