Who Should I Start? Joe Mixon or James Cook

Tuesday, October 7, 11:41 AM

Houston Texans general manager Nick Caserio said the team will have clarity on running back Joe Mixon's (foot/ankle) health status for the "duration of the year" at some point "over the next few weeks." Mixon has not played yet in 2025, and the team has provided little to no information about a possible return timeline. It seems possible, if not likely, that the 29-year-old will miss the entirety of the season. If that's the case, Houston will likely continue splitting backfield work between veteran Nick Chubb and rookie Woody Marks. Chubb has recorded 58 carries for 249 yards and two touchdowns so far this season. Marks has logged 233 yards from scrimmage and two touchdowns on 42 total touches, and could eventually work his way into the lead role over the course of the season.

Saturday, October 11, 1:46 PM

Buffalo Bills running back James Cook will face one of his toughest challenges of the season when he takes on Atlanta's sixth-ranked run defense on Monday night. The Falcons have excelled at controlling time of possession and limiting offensive opportunities, though they've allowed a 44.7% scoring rate on drives, leaving the door open for Cook to find the end zone. The third-year back is averaging 107.8 scrimmage yards and one touchdown per game, but he's coming off a sluggish performance against New England's opportunistic defense. While Cook's volume and role in Buffalo's high-powered offense keep him in RB1 territory, fantasy managers should temper expectations--his Week 6 success will likely hinge on finding pay dirt against a disciplined Falcons front.