Who Should I Start? Joe Mixon or James Cook

Monday, October 20, 3:31 PM

There remains no timetable for the return of Houston Texans running back Joe Mixon (ankle, foot), and there continue to be rumblings that he could miss the entire 2025 season. General manager Nick Caserio wouldn't say one way or another earlier this month whether he thought the 29-year-old RB would come off the Non-Football Injury list to join the active roster this year. The Texans should have more clarity on Mixon's health in another couple of weeks, but until then, fantasy managers stashing him in an Injured Reserve spot must stay patient. He was put on the NFI list before the start of training camp after injuring his ankle/foot during a workout in the spring. Although nothing is concrete yet, it's looking more likely that Mixon isn't going to be able to contribute in fantasy lineups in 2025. If that's the case, it will mean more opportunities for Nick Chubb and rookie Woody Marks the rest of the way.

Saturday, October 11, 1:46 PM

Buffalo Bills running back James Cook will face one of his toughest challenges of the season when he takes on Atlanta's sixth-ranked run defense on Monday night. The Falcons have excelled at controlling time of possession and limiting offensive opportunities, though they've allowed a 44.7% scoring rate on drives, leaving the door open for Cook to find the end zone. The third-year back is averaging 107.8 scrimmage yards and one touchdown per game, but he's coming off a sluggish performance against New England's opportunistic defense. While Cook's volume and role in Buffalo's high-powered offense keep him in RB1 territory, fantasy managers should temper expectations--his Week 6 success will likely hinge on finding pay dirt against a disciplined Falcons front.