Who Should I Start? Joe Mixon or James Cook

Thursday, November 20, 12:34 PM

Houston Texans running back Joe Mixon (ankle, foot) is not expected to play this season as he deals with a foot injury from the offseason, according to Ian Rapoport of NFL Network. Mixon will likely stay on the Physically Unable to Perform list through the end of the 2025 season, while the Texans move forward with veteran Nick Chubb and rookie Woody Marks in their backfield. Things had been trending this way for a while, as the Texans haven't been giving any real updates on Mixon for pretty much the entire season. Fantasy managers who are still stashing the 29-year-old in redraft leagues should send him to the waiver wire now. Mixon's injury dates all the way back to spring workouts. One would think he'd be ready for the start of the 2026 campaign, but there has been little information about the exact nature of his injury. Marks, a fourth-rounder in April, has slowly started to see more work and should be the backfield leader over Chubb by the end of the year.

Monday, December 1, 12:19 AM

The Buffalo Bills leaned heavily on running back James Cook in their 26-7 win over the Pittsburgh Steelers on Sunday. Cook handled a career high 32 carries for 144 yards to go along with three receptions (three targets) for a team-leading 33 receiving yards. The 26-year-old did it all for the Bills in a much-needed bounce-back win, and he continues to have an outstanding season after receiving a four-year, $48 million contract extension in the offseason. Cook has seen more work as a receiver lately as well, recording 14 receptions (14 targets) for 136 yards and a touchdown in his last four games. In the first eight games, he totaled 13 receptions (15 targets) for 100 yards and no touchdowns as a receiver. Cook will remain one of the best running backs in fantasy in a dream matchup next week against the Cincinnati Bengals.