Who Should I Start? Joe Mixon or James Cook

Monday, December 29, 1:56 PM

Houston Texans running back Joe Mixon (foot, ankle) will not return this season, league sources told Aaron Wilson of KPRC 2 Sports. The expectation all along has been that Mixon would not return at all in 2025, but now it's official. The Texans haven't released many details on the nature of Mixon's foot/ankle injury, but we know that he hasn't played since back in the spring. The 29-year-old remains on the Non-Football Injury list. At this point, it's fair to wonder if he'll be effective at all if he's able to make it back and play in 2026. The Texans will continue to move forward with rookie Woody Marks as their primary ball-carrier, with veteran Nick Chubb and rookie Jawhar Jordan backing him up heading into the Week 18 regular-season finale against the division-rival Indianapolis Colts.

Tuesday, January 13, 7:00 PM

After finishing the regular season with an NFL-best 1,621 rushing yards, Buffalo Bills running back James Cook had an underwhelming outing in his first game of the postseason. The 26-year-old was held to just 46 rushing yards on 15 carries and five receiving yards on two catches by the Jacksonville Jaguars. Cook's regular-season track record should afford him the benefit of the doubt from fantasy managers. However, he will face another very difficult run defense in the Divisional round when Buffalo travels to Denver to take on the Broncos. The Broncos defense finished the regular season ranked third in the NFL in yards per carry allowed (3.9) and tied for fourth in rushing touchdowns allowed (11). Additionally, Buffalo's already depleted pass-catching corps lost another two wide receivers in Gabe Davis (knee) and Tyrell Shavers (knee), who both suffered season-ending knee injuries in the Wild Card round. As a result, Denver could be even more geared up to stop Cook and take away the run. Cook remains a high-end running back option, but fantasy managers may want to downgrade expectations heading into the Divisional round.