Who Should I Start? Joe Mixon or James Cook

Monday, October 27, 2:56 PM

In what is becoming part of his weekly routine, Houston Texans head coach DeMeco Ryans told reporters on Monday that he has no update on the injury status of Pro Bowl running back Joe Mixon (foot). Mixon has been on the team's NFI list since the beginning of training camp after injuring his ankle/foot during a spring workout. More than halfway through the fantasy football regular season, managers who have kept him stashed on IR are potentially weighing their options as injuries continue to mount around the league. With the emergence of rookie Woody Marks and the loudening rumors that Mixon could miss the entirety of the season, he should no longer be viewed as a must-hold. At the same time, managers with the luxury of an open IR spot should monitor their own league's waivers, as he's dropped in more leagues each week.

Wednesday, November 5, 12:11 PM

Buffalo Bills head coach Sean McDermott said that running back James Cook (ankle, foot) will not practice on Wednesday due to an ankle/foot injury, according to Katherine Fitzgerald of The Buffalo News. Cook had another nice game in the team's Week 9 victory over the Kansas City Chiefs, carrying the ball 27 times for 114 yards while also catching one pass for 11 yards. However, the 26-year-old apparently came out of that game a little gimpy, and his status is now up in the air for the team's Week 10 tilt on the road against the division-rival Miami Dolphins. If Cook were to miss this weekend, Ty Johnson and Ray Davis would likely split backfield duties for the Bills in a great matchup. Cook has been a must-start RB1 every week in 2025, as he's currently the RB7 in fantasy in half-PPR scoring with 867 rushing yards and seven touchdowns on 153 carries.