Who Should I Start? Kyle Juszczyk or Isaac Guerendo

Sunday, September 14, 2:07 PM

San Francisco 49ers fullback Kyle Juszczyk (concussion) has been ruled out for the remainder of his team's Week 2 game against the New Orleans Saints. Juszczyk is a key piece of the San Francisco offense as both a blocker and receiver. The 49ers entered the game already without quarterback Brock Purdy (toe), tight end George Kittle (hamstring), and wide receiver Brandon Aiyuk (knee). Juszczyk's absence may create even more reason for San Francisco to get the ball in the hands of star running back Christian McCaffrey.

Saturday, September 6, 6:51 AM

Second-year running back Isaac Guerendo opens the season third on the 49ers' depth chart, though he may already see more action than originally anticipated. Christian McCaffrey (calf) popped up on the team's injury report this week and is tagged as questionable for San Francisco's Week 1 matchup against the Seahawks. Guerendo's only route to fantasy relevance relies on CMC sitting. If that does happen, then he can be seen as a deep-league flex candidate. Brian Robinson Jr. will likely draw the start, but Guerendo made his mark in 2024 in similar circumstances and is a potential RB4/5 pending McCaffrey's status.