Who Should I Start? Trey Benson or Isaac Guerendo

Wednesday, October 1, 2:19 PM

Arizona Cardinals running back Trey Benson (knee) is expected to miss four-to-six weeks after undergoing arthroscopic surgery on his meniscus, another setback for a backfield already reeling from the season-ending loss of James Conner (foot). Benson had been working into a steady role with 29 carries for 160 yards and 13 receptions for 64 yards through four games, but his absence now opens the door for Emari Demercado to take on feature-back responsibilities. Demercado should be added in all fantasy formats as he projects to see the bulk of opportunities in both the running and passing game, especially with Arizona lacking proven depth behind him. While Benson showed flashes of efficiency early, his return timetable places him on injured reserve and makes him droppable unless you have an IR spot available.

Wednesday, October 8, 11:50 AM

San Francisco 49ers running back Isaac Guerendo recorded 572 yards from scrimmage and four touchdowns on 99 total touches as a rookie in 2024. However, through five games in 2025, the 25-year-old has not played a single offensive snap. Guerendo is buried on the 49ers running back depth chart behind Christian McCaffrey and Brian Robinson Jr. As long as both McCaffrey and Robinson Jr. remain healthy, it appears unlikely that Guerendo's role in San Francisco's offense is going to change. Guerendo maintains some appeal in dynasty leagues, but he should remain off the radar of redraft fantasy managers for the time being.