Saturday Quarterback: Lamar Jackson ($8,000) at Buffalo Bills
A lot of tasty choices on the Saturday slate at quarterback (not you Jared Goff.) Unfortunately, a lot of good defenses are involved as well. I wouldn't fault you with taking any of the three, and you are probably going to want to diversify your lineups based on potential outcomes, but my top recommendation is Lamar Jackson. He's got the best matchup against a middling Bills defense and his price point gives you additional flexibility down your lineup.
Sunday Quarterback: Patrick Mahomes ($9,200) vs Cleveland Browns
There are plenty of options available, especially considering how cheap Brady, Mayfield, and Brees are compared to Mahomes. But that's because they are trying to bait you into not picking the guy who is far and away most likely to put up the most fantasy points of the four. Again, it's worth having some variety considering the two-game slate, but Mahomes against a team allowing the 8th most fantasy points to QB is a very good answer.