Who Should I Start? Alvin Kamara or Isaac Guerendo

Friday, December 5, 2:59 PM

New Orleans Saints running back Alvin Kamara (ankle, knee) has been ruled out for Sunday's Week 14 divisional matchup with the Buccaneers. Kamara was held out of practice with ankle and knee injuries and will now miss his second consecutive game. After a slow start in a Week 13 loss to the Dolphins, sixth-round rookie Devin Neal finished with 47 rushing yards on 14 carries while adding three catches for another 22 yards. He showed good decisiveness and burst, but struggled to find any space behind a banged-up and overmatched offensive line, evidenced by almost 94% of his rushing yardage coming after contact. Tampa Bay has been uncharacteristically soft against the run this season, so Neal remains a low-end RB2/flex play, especially in PPR formats, having earned 10 targets over the past two weeks.

Tuesday, October 21, 9:16 PM

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.