Who Should I Start? Brandon Aiyuk or Alec Pierce

Thursday, December 18, 4:18 PM

San Francisco 49ers head coach Kyle Shanahan said that wide receiver Brandon Aiyuk (knee) has been "extremely distant" from the team since suffering a season-ending knee injury in Week 7 of the 2024 season, per Matt Barrows of The Athletic. The 27-year-old has not played a game since that point. The 49ers voided guarantees in his contract for 2026 and placed him on the reserve/left squad list on Saturday, officially ending his 2025 season. All signs seem to indicate that Aiyuk and the 49ers are likely to go their separate ways this offseason. In his last fully healthy season in 2023, Aiyuk recorded 75 receptions for 1,342 yards and seven touchdowns on 105 targets. He has a chance to get back to his superstar heights if he can get fully healthy and find the right team. However, his health and the way his current situation in San Francisco has unfolded may bring about question marks for dynasty league fantasy managers.

Sunday, January 4, 5:09 PM

Indianapolis Colts wide receiver Alec Pierce caught four of his seven targets for 132 yards and two touchdowns during Sunday's Week 18 loss against the Houston Texans. His touchdowns came from eight and 66 yards out. Pierce was having a great outing and operating as Riley Leonard's favorite target before a costly mistake late in the game. With less than two minutes remaining in the third quarter, Pierce failed to haul in a pass near the back of the end zone. He pleaded his case for a pass interference penalty, and while doing so, he made contact with the official. As a result, Pierce was automatically disqualified from the game. Amid the blemish on an otherwise spectacular Week 18, the 25-year-old put the finishing touches on the best season of his career. In 2025, he caught 47 passes for 1,003 yards and six touchdowns while ranking as a top-36 fantasy receiver.