Who Should I Start? Christian McCaffrey or Justin Jefferson

Sunday, September 7, 9:17 PM

San Francisco 49ers running back Christian McCaffrey was the central focus of his team's offense in a 17-13 49ers' win over the Seattle Seahawks in Week 1. McCaffrey rushed 22 times for 69 yards and caught nine passes for 73 yards, a comforting sign for fantasy managers who might have been worried that a lingering calf issue would lead to San Francisco limiting his touches early in the season. The 49ers lost two offensive weapons in George Kittle (groin) and Jauan Jennings (shoulder) during the game. If Kittle and Jennings miss time going forward, San Francisco could be forced to lean on McCaffrey just as heavily in the weeks to come. As long as he's on the field, he's a must-start fantasy running back with game-breaking upside.

Saturday, September 6, 3:44 PM

Minnesota Vikings wide receiver Justin Jefferson is a must-start option, as usual, when the Vikings open the season against the Chicago Bears in Week 1. The sixth-year receiver dealt with a hamstring injury during training camp, but was not listed on Minnesota's final injury report and should continue to be the team's runaway top option for passing targets. Especially with fellow wide receiver Jordan Addison (suspension) out for the first three games, the All-Pro should receive plenty of volume from new starting quarterback J.J. McCarthy. Jefferson should be in starting lineups in every format.