Who Should I Start? Christian McCaffrey or Saquon Barkley

Saturday, December 20, 6:03 AM

San Francisco 49ers running back Christian McCaffrey will put a four-game touchdown streak on the line in Week 16 against the Colts. Last week, Indianapolis held Seahawks running backs Kenneth Walker III and Zach Charbonnet out of the end zone, but had given up at least one rushing touchdown to a running back in each of their six previous games. McCaffrey appears to be clear of the back injury that made him a surprising late addition to the 49ers' injury report last week, and should see plenty of work on Monday night. If Ricky Pearsall (knee/ankle) is unable to play, then CMC would likely reemerge as a candidate to lead the team in targets, as he has done six times already in 2025. Fantasy football managers should watch for the 49ers' final injury report, but assuming McCaffrey is fully healthy, he has the potential for a top-3 finish at his position.

Friday, December 19, 9:26 PM

Philadelphia Eagles running back Saquon Barkley has now scored touchdowns in consecutive games for the first time since the first two weeks of the season. Barkley's 22 carries were also his most attempts in a game since Week 11. The star RB was able to capitalize on the favorable matchup against the Raiders, and will look to do the same in his upcoming meeting with the Commanders. Washington's defense allows 136.3 rushing yards per game-fifth-most in the league-and has let up 14 rushing touchdowns-good for 12th-most in the NFL. It's also encouraging that Barkley had his most red zone rushing attempts in a game this season last week, getting the ball 10 times inside the 20 against Las Vegas. He's had a general uptick in touches and has returned to his scoring ways, so there's no doubt he's a solid RB1 this week.