Who Should I Start? Christian McCaffrey or Tyjae Spears

Saturday, December 20, 6:03 AM

San Francisco 49ers running back Christian McCaffrey will put a four-game touchdown streak on the line in Week 16 against the Colts. Last week, Indianapolis held Seahawks running backs Kenneth Walker III and Zach Charbonnet out of the end zone, but had given up at least one rushing touchdown to a running back in each of their six previous games. McCaffrey appears to be clear of the back injury that made him a surprising late addition to the 49ers' injury report last week, and should see plenty of work on Monday night. If Ricky Pearsall (knee/ankle) is unable to play, then CMC would likely reemerge as a candidate to lead the team in targets, as he has done six times already in 2025. Fantasy football managers should watch for the 49ers' final injury report, but assuming McCaffrey is fully healthy, he has the potential for a top-3 finish at his position.

Saturday, December 20, 3:11 PM

Tennessee Titans running back Tyjae Spears recorded just five touches for 36 yards in last week's loss to the San Francisco 49ers. It was the third year back's fewest touches in a game since Week 5, his first game of the season after opening the year on Injured Reserve with an ankle injury. Spears' role in the Titans' offense hasn't expanded with Tony Pollard locking down the lead back duties and delivering his two best performances of the season in the last two weeks. The 24-year-old has just one game this season with double-digit PPR points, coming back in Week 8. Spears will remain a low-upside FLEX option in a tough Week 16 matchup versus the Kansas City Chiefs, who have allowed the fourth fewest PPR points per game to running backs.