Who Should I Start? Isaac Guerendo or Dylan Sampson

Friday, June 6, 12:54 PM

San Francisco 49ers running back Isaac Guerendo (ankle, knee) has been taking part in voluntary organized team activities this spring after injuring his MCL and spraining his ankle in the Week 18 regular-season finale last year. Guerendo, a fourth-round pick (129th overall) in 2024, should be a full-go for the start of mandatory minicamp on June 10. All-Pro Christian McCaffrey (knee) is also back and ready to roll after missing the majority of the 2024 campaign, so Guerendo will enter the 2025 season as the backup, but Jordan Mason was traded to the Minnesota Vikings and Elijah Mitchell left in free agency. The 24-year-old Guerendo had 5.0 yards per carry on his 84 rushing attempts last year for 420 yards and four touchdowns in 16 games (three starts), adding 15 catches for 152 yards through the air. Consider him a high-upside handcuff behind the injury-prone CMC.

Saturday, June 28, 11:38 AM

Cleveland Browns rookie fourth-round running back Dylan Sampson received work "as a running back and a receiver" during minicamp, according to RBs coach Duce Staley. Staley went on to add that Sampson "is able to go play in the slot and also he's able to go and play on third down and maybe sprinkle in a little second down." The Cleveland Plain Dealer's Dan Labbe thinks that heading into training camp, rookies Quinshon Judkins and Sampson figure to be the top two backs, with Jerome Ford serving as the primary third-down back. The 20-year-old Sampson rushed for 1,491 yards and 22 touchdowns (5.8 yards per carry) in 2024 at Tennessee, but he wasn't all that involved as a pass-catcher. He's a speedy back that could be worth a dart throw in deep PPR formats, but most likely he'll be an inconsistent fantasy performer unless Judkins misses time with an injury.