Who Should I Start? Isaac Guerendo or Dylan Sampson

Thursday, May 28, 1:46 PM

San Francisco 49ers running back Isaac Guerendo (pectoral) tore his pectoral muscle lifting weights around a month ago, and head coach Kyle Shanahan said that he could be ready at the end of training camp this summer, according to Adam Schefter of ESPN. Torn pectoral muscles typically end a player's season, so we're still a bit skeptical that the 25-year-old will be ready so soon. Even before his injury, the former fourth-rounder in 2024 out of Louisville had seen his stock drop considerably after not seeing a single offensive snap in Shanahan's offense in 2025 in his second year in the NFL. Brian Robinson Jr., who was the team's backup behind Christian McCaffrey last season, is now in Atlanta, but both Jordan James and rookie fifth-rounder Kaelon Black probably have a clearer path to RB2 duties in the Bay Area in 2026, especially now that Guerendo is going to miss the start of camp. Guerendo has elite speed and averaged 5.0 yards per carry on 84 rushing attempts in 16 games as a rookie, but his redraft and dynasty stock are currently at an all-time low.