Who Should I Start? Isaac Guerendo or Dylan Sampson

Wednesday, February 18, 10:02 AM

San Francisco 49ers running back Isaac Guerendo has emerged as a potential drop candidate as dynasty managers prepare for the offseason roster crunch. Between clearing taxi squad spots, adding players, and navigating rookie drafts, dynasty managers may need to make decisions about which rostered players to cut. Guerendo is a prime candidate after an underwhelming second season with the 49ers in 2025. He appeared in 14 games but played exclusively on special teams, never logging an offensive snap. He was buried on the depth chart behind Christian McCaffrey, Brian Robinson Jr., Jordan James, and even fullback Kyle Juszczyk. It was a surprising, harsh development for the Louisville product after he finished as the overall RB48 in PPR leagues with 572 scrimmage yards and five touchdowns in 2024. Evidently, the 49ers don't see Guerendo in their long-term plans, and it's hard to imagine he'll climb the depth chart in 2026, even with Robinson expected to hit free agency. Managers in most dynasty leagues should feel comfortable dropping the 25-year-old.