Who Should I Start? Isaac Guerendo or Omarion Hampton

Saturday, September 27, 5:08 AM

San Francisco 49ers running back Isaac Guerendo has yet to see an offensive snap in 2025, and there is little reason to expect that to change in Week 4. Christian McCaffrey is the team's unquestioned starter, and Brian Robinson Jr. has the second position on the depth chart locked down. The team's official depth chart lists both Guerendo and rookie Jordan James as the third-string running back, raising the question of which of the two would be given an opportunity in the backfield should the need arise. In the meantime, Guerendo has been relegated to kick return duty. Through three games, he has taken back four kicks for a grand total of 82 yards. Until an injury shakes up the depth chart, Guerendo has no place on fantasy football rosters.

Friday, September 26, 3:24 PM

Los Angeles Chargers rookie running back Omarion Hampton is primed for a heavy workload following the season-ending injury to Najee Harris (Achilles). In the team's 23-20 win over the Denver Broncos, Hampton recorded 19 carries for 70 yards and a touchdown, along with six catches for 59 yards, demonstrating his value in both the running and passing game. The 0-3 New York Giants are an ideal matchup, ranking in the bottom third in every defensive category and allowing the second-most rushing yards in the league. Although the absence of guard Mekhi Becton (concussion) could create some vulnerability, Hampton's expected workhorse role and favorable opponent position him for a strong performance. RotoBaller projects Hampton as RB10 this week and considers him a must-start across all formats.