Who Should I Start? Isaac Guerendo or Omarion Hampton

Tuesday, October 21, 9:16 PM

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.

Wednesday, November 26, 7:21 PM

Los Angeles Chargers rookie first-round running back Omarion Hampton (ankle) said he was dealing with a fractured ankle, according to Daniel Popper of The Athletic. Hampton also said he feels "amazing" and is hoping to be a full-go once he's activated from Injured Reserve. The 22-year-old Ohio State product fractured his ankle in Week 5 and has been out since, but he returned to a limited practice on Wednesday and has a shot to play this Sunday versus the division-rival Las Vegas Raiders. Offensive coordinator Greg Roman hinted this week that Hampton could be in a timeshare with Kimani Vidal upon his return, which somewhat clouds his fantasy value upon his return. Hampton showed just before his ankle fracture that he's capable of RB1 upside with a heavy workload, but fantasy managers may want to temper expectations initially if L.A. looks to ease him back into the fold.