Who Should I Start? Isaac Guerendo or Omarion Hampton

Tuesday, October 21, 9:16 PM

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.

Tuesday, December 16, 9:50 PM

Los Angeles Chargers running back Omarion Hampton missed seven games in the middle of the 2025 season due to an ankle injury, but he made his return to the field in Week 14. The Chargers have worked Hampton back in slowly, as he's split backfield snaps with Kimani Vidal over each of the past two weeks. Even with the limited playing time, Hampton has provided modest production. Over his last two games, the 22-year-old has recorded 132 scrimmage yards and a touchdown on 31 touches. In his final two full games before suffering the ankle injury, Hampton demonstrated his explosive upside by logging 294 yards from scrimmage and two touchdowns on 42 touches. If the Chargers continue to increase his workload as he gets healthier, Hampton could get back to his pre-injury levels of production. Los Angeles will face the Dallas Cowboys in Week 16 before hosting the Houston Texans in Week 17.