Who Should I Start? Isaac Guerendo or Omarion Hampton

Monday, December 22, 7:11 PM

San Francisco 49ers running back Jordan James is active for Monday's Week 16 contest against the Indianapolis Colts and is on track to make his NFL debut. The rookie had previously been a healthy scratch, but he's getting a chance to play on primetime television, perhaps in a mix of special teams and offensive depth roles. He's taking the spot of fellow rookie Isaac Guerendo, who is a healthy scratch for the first time in his young career. Guerendo has contributed on special teams this year, but he doesn't have an offensive snap yet. Both running backs remain buried on the depth chart behind Christian McCaffrey and Brian Robinson Jr.

Sunday, January 11, 7:42 PM

Los Angeles Chargers rookie running back Omarion Hampton (ankle) is officially active for Sunday's playoff contest against the New England Patriots. He had been listed as questionable and missed a pair of practices before being upgraded to a limited participant on Friday. Hampton sat out Week 18 with an ankle injury, but his absence was more of a precaution as Los Angeles rested many starters, and the rookie running back was just four weeks removed from a seven-game absence. He took a little while to get back to 100 percent after the injury, but his 81% snap share and 22 touches from Week 17 should indicate that he's back to a starter's workload. We wouldn't be surprised to see him handle another 20-plus touches against the Patriots, whose run defense started to falter down the stretch but still finished with the third-fewest fantasy points allowed to opposing running backs in 2025.