Who Should I Start? Isaac Guerendo or Omarion Hampton

Tuesday, October 21, 9:16 PM

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.

Friday, November 7, 4:57 PM

Los Angeles Chargers rookie running back Omarion Hampton (ankle) worked off to the side at Friday's practice, according to Daniel Popper of The Athletic. Hampton appears to be making progress in his recovery after an extended period with no positive updates. The rookie running back was placed on Injury Reserve after suffering an ankle injury in Week 5 against the Washington Commanders. Head coach Jim Harbaugh said on Monday that he doesn't expect Hampton's 21-day practice window to be opened until after the Chargers' Week 12 bye. Second-year back Kimani Vidal has played well in Hampton's absence and will continue to be a decent RB2/flex option until Hampton is activated from IR to take over the RB1 duties in a few weeks.