Who Should I Start? J.K. Dobbins or Isaac Guerendo

Wednesday, October 8, 11:15 AM

Denver Broncos running back J.K. Dobbins has "been fantastic," according to Broncos head coach Sean Payton. The 26-year-old is in his first year with the team and has gotten off to a fast start to the season, rushing for 402 yards and four touchdowns on 77 carries through five games. Dobbins does not offer much as a receiver (six total receptions), but he's been the clear lead rusher in a Broncos backfield that also features RJ Harvey and Tyler Badie. Health has always been a question mark for Dobbins, as he had played in just 22 games over his previous three seasons coming into 2025. However, if he stays healthy, it does not appear he's in any danger of losing his current role in Denver. Dobbins profiles as a must-start fantasy running back in Week 6 against the New York Jets.

Wednesday, October 8, 11:50 AM

San Francisco 49ers running back Isaac Guerendo recorded 572 yards from scrimmage and four touchdowns on 99 total touches as a rookie in 2024. However, through five games in 2025, the 25-year-old has not played a single offensive snap. Guerendo is buried on the 49ers running back depth chart behind Christian McCaffrey and Brian Robinson Jr. As long as both McCaffrey and Robinson Jr. remain healthy, it appears unlikely that Guerendo's role in San Francisco's offense is going to change. Guerendo maintains some appeal in dynasty leagues, but he should remain off the radar of redraft fantasy managers for the time being.