Who Should I Start? Jacoby Brissett or James Cook

Tuesday, November 4, 6:34 PM

Arizona Cardinals head coach Jonathan Gannon announced on Tuesday that quarterback Jacoby Brissett will make a fourth straight start under center for the team's Week 10 divisional matchup against the Seattle Seahawks on Sunday, per ESPN's Adam Schefter. The Cardinals will stick with Brissett for another game while Murray heals from a mid-foot sprain that he suffered back in Week 5, but they are taking things week-to-week at the QB position. Head coach Jonathan Gannon said after Monday night's win over the Dallas Cowboys that Murray is still the team's starter when healthy, but he went back on that statement a day later. The bottom line is that the 32-year-old Brissett has helped improve the offense in his three starts, going 73-for-111 (65.8% completion percentage) with at least two touchdown passes each game. If he continues to play well, the Cardinals could continue to sit Murray on the bench. Brissett will be a low-end QB2 streamer in Week 10 in fantasy on the road against a tough Seahawks defense.

Wednesday, November 5, 12:11 PM

Buffalo Bills head coach Sean McDermott said that running back James Cook (ankle, foot) will not practice on Wednesday due to an ankle/foot injury, according to Katherine Fitzgerald of The Buffalo News. Cook had another nice game in the team's Week 9 victory over the Kansas City Chiefs, carrying the ball 27 times for 114 yards while also catching one pass for 11 yards. However, the 26-year-old apparently came out of that game a little gimpy, and his status is now up in the air for the team's Week 10 tilt on the road against the division-rival Miami Dolphins. If Cook were to miss this weekend, Ty Johnson and Ray Davis would likely split backfield duties for the Bills in a great matchup. Cook has been a must-start RB1 every week in 2025, as he's currently the RB7 in fantasy in half-PPR scoring with 867 rushing yards and seven touchdowns on 153 carries.