Who Should I Start? James Cook or Dylan Sampson

Sunday, December 21, 5:54 PM

Buffalo Bills running back James Cook had 16 carries, 117 rushing yards, and two rushing touchdowns during Sunday's Week 16 win over the Cleveland Browns. He also converted two targets into one catch for 17 receiving yards. Cook's quest for the NFL rushing title continued against a Browns defense that has been absolutely ripped apart by opposing running backs over the last three weeks. Buffalo's primary ball-carrier now has 14 touchdowns and over 1,800 scrimmage yards on the year, including five trips to the end zone in his last two games. Preseason concerns that Cook was due for regression have been completely unfounded, as he remains one of the top fantasy running backs while continuing to play a massive role around the goal line. He's a very strong RB1 option with a high ceiling heading into Week 17 against the Philadelphia Eagles.

Wednesday, December 24, 11:36 AM

Cleveland Browns running back Dylan Sampson (hand) is expected to return to practice on Wednesday, per ESPN's Daniel Oyefusi. Sampson has missed each of Cleveland's last two games due to calf and hand injuries. The 21-year-old has mostly been used in a part-time role as a receiver out of the backfield so far in 2025. However, with Browns RB1 Quinshon Judkins (leg, ankle) suffering a season-ending injury in Week 16, Sampson has an opportunity to take over as the team's lead back. Across 13 games this season, Sampson has racked up 375 scrimmage yards and two touchdowns on 72 touches. The Browns also have Raheim Sanders and Trayveon Williams as backfield options who can help fill in for Judkins. If active, Sampson could be a solid flex option for fantasy managers in his Week 17 matchup against the Pittsburgh Steelers.