Who Should I Start? Joe Mixon or Christian McCaffrey

Wednesday, January 21, 12:19 PM

Houston Texans general manager Nick Caserio said on Wednesday that running back Joe Mixon (foot, ankle) had a medical condition that never improved, according to Jonathan M. Alexander of the Houston Chronicle. "He didn't jump off a building. He wasn't doing anything irresponsible. It was a freak thing," Caserio said. The Texans were extremely vague with Mixon's injury all year, and he never ended up playing in 2025. Head coach DeMeco Ryans said on Monday that Mixon's status for the 2026 season is also uncertain due to his injury. Unexpectedly, the Texans struggled for consistent production out of their backfield with a mix of veteran Nick Chubb and Woody Marks. Marks took over halfway through the year and should be heavily involved again next season, even if Mixon returns. Needless to say, a lot of fantasy managers won't want anything to do with Mixon in 2026.

Saturday, January 17, 10:30 PM

San Francisco 49ers running back Christian McCaffrey (shoulder) exited with a stinger during the third quarter of Saturday's Divisional Round contest against the Seattle Seahawks. He was briefly listed as questionable to return, but he checked back into the game midway through the third quarter. The superstar running back took multiple hits throughout the first 30-plus minutes of game action, and he was seeing testing his injury on the sideline. At the time of his initial departure, McCaffrey had totaled nine carries, 29 rushing yards, five catches, and 39 receiving yards. Bad injury news has plagued the 49ers left and right. In addition to various defensive injuries throughout the regular season, San Francisco lost George Kittle (Achilles) last week, and Jake Tonges (foot) is currently listed as questionable to return against Seattle. For the time being, McCaffrey will try to play through his injury with the 49ers' season on the line. However, we wouldn't be surprised to see No. 2 running back Brian Robinson Jr. earn more snaps while McCaffrey manages his injury.