Who Should I Start? Jonathan Taylor or Isaac Guerendo

Sunday, December 28, 9:25 PM

Indianapolis Colts running back Jonathan Taylor did not have his most efficient day in his team's 23-17 Week 17 loss to the Jacksonville Jaguars, but he was able to volume his way to solid production. Taylor recorded 21 carries for 70 yards and a touchdown and also hauled in three receptions for 14 yards on six targets. The 26-year-old has now recorded 1,924 yards from scrimmage and 20 touchdowns on 353 touches across 16 games in 2025. While Taylor's numbers for the season are excellent, he's struggled with efficiency throughout the second half of the season. Including Week 17, he's averaged fewer than four yards per carry in five out of his last six games. Still, the Colts' offense remains built around Taylor, as he's recorded at least 18 touches in every game but two this season. Indianapolis will travel to Houston to take on the Texans in Week 18.

Monday, December 22, 7:11 PM

San Francisco 49ers running back Jordan James is active for Monday's Week 16 contest against the Indianapolis Colts and is on track to make his NFL debut. The rookie had previously been a healthy scratch, but he's getting a chance to play on primetime television, perhaps in a mix of special teams and offensive depth roles. He's taking the spot of fellow rookie Isaac Guerendo, who is a healthy scratch for the first time in his young career. Guerendo has contributed on special teams this year, but he doesn't have an offensive snap yet. Both running backs remain buried on the depth chart behind Christian McCaffrey and Brian Robinson Jr.