Who Should I Start? Miles Sanders or Isaac Guerendo

Sunday, October 5, 12:04 PM

Dallas Cowboys running back Miles Sanders (ankle, knee) is officially inactive for the Week 5 game on the road against the New York Jets at MetLife Stadium on Sunday, according to Nick Harris of the Fort Worth Star-Telegram. Sanders came into this game listed as questionable despite not being able to practice all week. With the 28-year-old out of action for the first time this season, rookie Jaydon Blue will suit up for his NFL debut as the backup behind starter Javonte Williams. Although the fifth-round rookie might be eased into the offense in his first regular-season game, Blue is worth stashing in deeper leagues for his upside the rest of the season. It's unclear if Sanders will be able to return in Week 6 against the Carolina Panthers. In addition to Blue, Hunter Luepke could have a bigger role in Dallas' backfield on Sunday behind Williams.

Saturday, September 27, 5:08 AM

San Francisco 49ers running back Isaac Guerendo has yet to see an offensive snap in 2025, and there is little reason to expect that to change in Week 4. Christian McCaffrey is the team's unquestioned starter, and Brian Robinson Jr. has the second position on the depth chart locked down. The team's official depth chart lists both Guerendo and rookie Jordan James as the third-string running back, raising the question of which of the two would be given an opportunity in the backfield should the need arise. In the meantime, Guerendo has been relegated to kick return duty. Through three games, he has taken back four kicks for a grand total of 82 yards. Until an injury shakes up the depth chart, Guerendo has no place on fantasy football rosters.