Who Should I Start? Raheem Mostert or Isaac Guerendo

Sunday, September 7, 12:00 PM

Las Vegas Raiders running back Raheem Mostert is inactive for Week 1 of the 2025 regular season on Sunday against the New England Patriots. Mostert is healthy heading into the regular-season opener, so this is a bad sign for his potential involvement in the Raiders' backfield this year in his first year with the team. The Raiders drafted rookie Ashton Jeanty in the first round in April, and he's fully expected to lead Vegas' backfield in his first year in the NFL. The oft-injured Mostert has now been bumped down the depth chart and will open the year as the RB4 behind Jeanty, Zamir White and Dylan Laube. The 33-year-old veteran can be dumped if you were rostering him as a handcuff for Jeanty in redraft leagues. Mostert led the league with 18 rushing touchdowns in 2023 in Miami but played in 13 games last year and fell to just two TDs.

Saturday, September 6, 6:51 AM

Second-year running back Isaac Guerendo opens the season third on the 49ers' depth chart, though he may already see more action than originally anticipated. Christian McCaffrey (calf) popped up on the team's injury report this week and is tagged as questionable for San Francisco's Week 1 matchup against the Seahawks. Guerendo's only route to fantasy relevance relies on CMC sitting. If that does happen, then he can be seen as a deep-league flex candidate. Brian Robinson Jr. will likely draw the start, but Guerendo made his mark in 2024 in similar circumstances and is a potential RB4/5 pending McCaffrey's status.