Who Should I Start? Travis Etienne Jr. or Isaac Guerendo

Sunday, September 28, 9:38 PM

Jacksonville Jaguars running back Travis Etienne Jr. dominated the San Francisco 49ers with 19 carries for 124 yards and a touchdown in his team's 26-21 Week 4 win. The 26-year-old is off to a terrific start to the 2025 season, with 65 carries for 394 yards and two touchdowns as a rusher, and six catches for 32 yards and a score as a receiver through his first four games. Etienne Jr. is also dominating backfield touches in Jacksonville so far, as Jaguars backup running backs Bhayshul Tuten and LeQuint Allen Jr. combined for just six touches in Week 4. Etienne Jr. profiles as a must-start fantasy running back going into a Week 5 showdown with the Kansas City Chiefs.

Wednesday, October 8, 11:50 AM

San Francisco 49ers running back Isaac Guerendo recorded 572 yards from scrimmage and four touchdowns on 99 total touches as a rookie in 2024. However, through five games in 2025, the 25-year-old has not played a single offensive snap. Guerendo is buried on the 49ers running back depth chart behind Christian McCaffrey and Brian Robinson Jr. As long as both McCaffrey and Robinson Jr. remain healthy, it appears unlikely that Guerendo's role in San Francisco's offense is going to change. Guerendo maintains some appeal in dynasty leagues, but he should remain off the radar of redraft fantasy managers for the time being.