These are the top fantasy football players of the Buffalo Bills as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of December 3, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Home | Baltimore Ravens |
| 2 | Away | New York Jets |
| 3 | Home | Miami Dolphins |
| 4 | Home | New Orleans Saints |
| 5 | Home | New England Patriots |
| 6 | Away | Atlanta Falcons |
| 8 | Away | Carolina Panthers |
| 9 | Home | Kansas City Chiefs |
| 10 | Away | Miami Dolphins |
| 11 | Home | Tampa Bay Buccaneers |
| 12 | Away | Houston Texans |
| 13 | Away | Pittsburgh Steelers |
| 14 | Home | Cincinnati Bengals |
| 15 | Away | New England Patriots |
| 16 | Away | Cleveland Browns |
| 17 | Home | Philadelphia Eagles |
| 18 | Home | New York Jets |
Buffalo Bills tight end Dawson Knox was on the field for 53 offensive snaps in Sunday's win over the Steelers, a team-high amongst all non-QB skill position players. His four targets also tied for the team lead on a day in which Josh Allen attempted only 23 total passes. Unfortunately, Knox finished the day with only three catches for 28 yards. He has not scored a touchdown since Week 6, and despite playing the past three games with a combination of a benched Keon Coleman and an injured Dalton Kincaid, he has averaged 2.3 receptions for 22.7 yards. With Kincaid able to return to practice on a limited basis last week, there is an expectation that he could be back for the Bills' Week 14 matchup with the Bengals, officially closing the window on any streaming consideration for Knox.
December 2, 2025 2:41 PM EST
Buffalo Bills kicker Tyler Bass (groin, hip) underwent surgery on his groin/hip and will not kick again this season, according to head coach Sean McDermott. Bass will end up missing the entire 2025 season and will close out the year on Injured Reserve. Veteran Matt Prater has been filling in for Bass all year in Buffalo and has made 17 of his 19 field-goal attempts (89.5%) and 34 of his 37 extra-point tries in 12 games played. In fantasy football, Prater has been the No. 14 kicker in terms of overall points, and he'll definitely be in play for the upcoming Week 14 matchup against the Cincinnati Bengals and their generous defense. Bass signed a four-year contract extension with Buffalo in 2023, so he should be back with the team next year if he's recovered from his injuries.
December 1, 2025 4:39 PM EST
The Buffalo Bills leaned heavily on running back James Cook in their 26-7 win over the Pittsburgh Steelers on Sunday. Cook handled a career high 32 carries for 144 yards to go along with three receptions (three targets) for a team-leading 33 receiving yards. The 26-year-old did it all for the Bills in a much-needed bounce-back win, and he continues to have an outstanding season after receiving a four-year, $48 million contract extension in the offseason. Cook has seen more work as a receiver lately as well, recording 14 receptions (14 targets) for 136 yards and a touchdown in his last four games. In the first eight games, he totaled 13 receptions (15 targets) for 100 yards and no touchdowns as a receiver. Cook will remain one of the best running backs in fantasy in a dream matchup next week against the Cincinnati Bengals.
December 1, 2025 12:19 AM EST
Buffalo Bills wide receiver Joshua Palmer (ankle) is officially inactive for Sunday's game against the Pittsburgh Steelers due to an ankle injury. Palmer returned from injury in Week 12 against the Houston Texans, recording two catches (four targets) for 21 yards, but entered Week 13 listed as questionable and will ultimately not suit up. The 26-year-old hasn't made a big impact since signing with the Bills in the offseason, totaling 18 receptions for 272 yards and no touchdowns on 29 targets in eight games. Keon Coleman and Brandin Cooks are both active on Sunday against Pittsburgh and should factor into the passing game along with Khalik Shakir with Palmer sidelined.
November 30, 2025 4:27 PM EST
Buffalo Bills wide receiver Keon Coleman is active on Sunday against the Pittsburgh Steelers for the first time since Week 10 against the Miami Dolphins. Coleman was a healthy inactive for the past two games for disciplinary reasons after being late to a team meeting. The 22-year-old has had a disappointing sophomore season so far, recording 32 receptions for 330 yards and three touchdowns on 49 targets in nine games. Ideally, the Bills taking action and sitting Coleman down for two games will lead to better days for him. He gets a great opportunity on Sunday against a Steelers defense that has allowed the fourth-most PPR points per game to opposing wide receivers.
November 30, 2025 4:14 PM EST
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