These are the top fantasy football players of the Buffalo Bills as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of October 1, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Home | Baltimore Ravens |
| 2 | Away | New York Jets |
| 3 | Home | Miami Dolphins |
| 4 | Home | New Orleans Saints |
| 5 | Home | New England Patriots |
| 6 | Away | Atlanta Falcons |
| 8 | Away | Carolina Panthers |
| 9 | Home | Kansas City Chiefs |
| 10 | Away | Miami Dolphins |
| 11 | Home | Tampa Bay Buccaneers |
| 12 | Away | Houston Texans |
| 13 | Away | Pittsburgh Steelers |
| 14 | Home | Cincinnati Bengals |
| 15 | Away | New England Patriots |
| 16 | Away | Cleveland Browns |
| 17 | Home | Philadelphia Eagles |
| 18 | Home | New York Jets |
Buffalo Bills wide receiver Khalil Shakir has reestablished himself as the team's WR1. After a slow start, Shakir has hauled in all nine of his targets for 114 yards and two touchdowns over the past two weeks, ranking as the WR14 during that span. Despite rookie Keon Coleman's explosive Week 1 performance, Shakir has now surpassed him in nearly every statistical category. Shakir draws a favorable Week 5 matchup against the Patriots, who have allowed the 11th-most fantasy points to wideouts this season. While his usage in Joe Brady's offense remains limited, Shakir profiles as a low-end WR3 for the rest of the 2025 season.
September 30, 2025 6:43 PM EST
Buffalo Bills running back James Cook posted another huge game in Week 4 in his team's 31-19 victory over the New Orleans Saints. Cook recorded 117 yards and a touchdown on 22 carries and added three catches for 18 yards for good measure as well. The 26-year-old has now logged 401 rushing yards and five touchdowns on 75 carries and 12 receptions for 89 yards through his first four games of 2025. He dominated backfield touches in Week 4, earning 22 out of 24 rush attempts by running backs for Buffalo against New Orleans. As long as he's healthy, Cook is a must-start fantasy running back.
September 28, 2025 9:47 PM EST
Buffalo Bills quarterback Josh Allen didn't have a huge day in terms of passing yardage, but was able to get the job done. Allen completed 16-of-22 passing attempts for 209 yards with two touchdowns and one interception. He also added 45 yards on seven rushing attempts with an additional touchdown on the ground. This was a solid three-score game for Allen as they were able to take down the New Orleans Saints. The Bills offense certainly had troubles at times during this game, but they were able to get the job done. Allen will remain an elite fantasy option for the Week 5 matchup against the New England Patriots.
September 28, 2025 6:31 PM EST
Buffalo Bills wide receiver Keon Coleman has cooled off considerably since his strong Week 1 breakout. Over the past two games, Coleman has totaled only six receptions for 46 yards, as the Bills have shifted toward a more run-heavy approach. Positive game script has also limited his involvement, with Buffalo holding comfortable leads in Weeks 2 and 3 and relying less on Josh Allen's arm. That trend could continue in Week 4, as the Bills are 15.5-point favorites against the New Orleans Saints. The matchup itself is relatively easy, with New Orleans allowing the 10th-most fantasy points to wide receivers this season. Given the reduced usage and expected negative game script, Coleman should be viewed as a risky FLEX play rather than a reliable starter.
September 27, 2025 11:12 AM EST
With 13 catches, 151 yards, and two touchdowns, Buffalo Bills tight end Dalton Kincaid has gotten off to a fast start three weeks into the 2025 season. Not only has the third-year man already matched his TD total from each of his first two seasons, but he has led the Bills in targets (12) over the past two weeks. He'll attempt to continue his success in Week 4 against the winless New Orleans Saints. They rank a slightly below-average 14th in fantasy points allowed to opposing TEs this season, though they haven't faced a high-end starter since taking on the Arizona Cardinals' Trey McBride in Week 1. McBride recorded six catches for 61 yards on nine targets in a a season-opening victory. Kincaid probably won't have nine passes thrown his way this week, but thanks to his growing rapport with quarterback Josh Allen, he looks like a top 10 TE heading into Sunday.
September 26, 2025 4:02 PM EST
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