Who Should I Start? Alvin Kamara or James Cook

Friday, December 12, 2:41 PM

New Orleans Saints running back Alvin Kamara (knee, ankle) has been ruled out for the third straight week with injuries to his knee and ankle. 6th-round rookie Devin Neal (abdomen), coming off an RB12 finish in a Week 14 win over the Buccaneers, has been limited at practice with an abdomen issue of his own. The Saints' final practice report of the week bears watching, because if Neal is unable to suit up for a Week 15 divisional matchup with the Panthers, New Orleans is left with Audric Estime and Evan Hull atop the running back depth chart. Carolina's defense has been a plus matchup for opposing running backs, so if Neal is able to go on Sunday, he should be viewed as a safe floor RB2/flex play.

Sunday, December 14, 9:42 PM

Buffalo Bills running back James Cook put up a dominant performance in his team's critical Week 15 win over its division rival, the New England Patriots, on Sunday. Cook recorded 22 carries for 107 yards and two touchdowns, and two receptions for four yards and a score. The 26-year-old has now racked up 1,686 yards from scrimmage and 12 touchdowns on 302 touches across 14 games this season. Cook has topped 100 scrimmage yards in five straight games and 11 out of 14 total contests in 2025. He also continues to dominate backfield touches in Buffalo, logging 22 of the team's 26 rushing attempts by running backs in Week 15. Cook profiles as a must-start fantasy running back heading into a Week 16 matchup against the Cleveland Browns.