Who Should I Start? Alvin Kamara or James Cook

Sunday, November 23, 10:37 PM

New Orleans Saints running back Alvin Kamara's (knee) MRI exam showed an MCL sprain, a source told Nick Underhill of New Orleans Football. Kamara avoided a major injury in Sunday's loss to the Atlanta Falcons in Week 12, but it's unclear if he'll be forced to miss time. It's possible that the 30-year-old misses time, but he is not dealing with a long-term injury. Fantasy managers should expect Kamara to miss at least one game, which means that rookie Devin Neal would be in line for lead-back duties in a strong matchup in Week 13 against the Miami Dolphins. Kamara has been a major disappointment for fantasy managers in 2025 in a struggling Saints offense. He had only three carries for 11 yards and caught both his targets for four yards on Sunday before leaving early. Neal finished with seven carries for 18 yards and caught five of seven targets for 43 yards through the air. Taysom Hill had a team-high 10 carries for 17 yards and will also be much more involved in the backfield for the Saints if Kamara misses time going forward.

Thursday, November 20, 11:30 PM

Buffalo Bills running back James Cook had 17 carries for 116 rushing yards and one rushing touchdown during Thursday's Week 12 loss against the Houston Texans. He also caught all three of his targets for an additional 13 receiving yards. The highlight of his game was a 45-yard touchdown run to break the scoreless tie in the first quarter. Even as the Bills' offense was slowed down by the Texans' strong defense, Cook still had a very productive game and carved out a terrific fantasy performance once again. He logged his first rushing touchdown since Week 8 and now has nine trips to the end zone this season. He remains a high-end RB1 option heading into Week 13 against the Pittsburgh Steelers.