Who Should I Start? Baker Mayfield or Kyler Murray

Sunday, October 12, 9:52 PM

Tampa Bay Buccaneers quarterback Baker Mayfield led his team to its fifth win of the season in Week 6, beating the San Francisco 49ers 30-19. Mayfield completed 17 of his 23 pass attempts for 256 yards and two touchdowns without throwing an interception and added 14 rushing yards on three carries. The 30-year-old has now thrown for 1,309 yards and 12 touchdowns in his first six games of 2025. Tampa Bay entered Week 6 without wide receivers Mike Evans (hamstring), Chris Godwin (leg), and Jalen McMillan (neck), and then lost star rookie wideout Emeka Egbuka (hamstring) to a hamstring injury during the game. It's currently unclear how long the Buccaneers will be without their top four wide receivers. Regardless, Mayfield has proven himself to be a worthy fantasy QB1 on a week-to-week basis.

Sunday, October 12, 11:31 AM

Arizona Cardinals quarterback Kyler Murray (foot) is officially inactive for Sunday's Week 6 contest against the Indianapolis Colts. He had been listed as questionable after missing two practices and logging a limited session on Friday. Arizona left the door open for him to play, but there were plenty of reports on Saturday that indicated Murray was unlikely to suit up. Indeed, he is inactive on Sunday and will temporarily hand over the starting job to Jacoby Brissett. The veteran makes his first start of the season, as well as his first start as an Arizona Cardinal, and he'll do so against one of his former teams. The 32-year-old is a solid passer with some mobility, so Cardinals fans and fantasy managers should feel optimistic that Brissett can keep the team competitive while supporting solid fantasy performances from players like Marvin Harrison Jr., Trey McBride, and Bam Knight.