Who Should I Start? Christian McCaffrey or Isiah Pacheco

Sunday, September 14, 8:39 PM

San Francisco 49ers running back Christian McCaffrey rushed for 55 yards on 13 carries during Sunday's Week 2 victory over the New Orleans Saints. He also caught six of seven targets for an additional 53 receiving yards and one receiving touchdown. Although the veteran playmaker didn't quite eclipse the 100-yard mark, he made up for it by scoring his first touchdown of the 2025 campaign. He also served as a very valuable and dependable pass-catching option for quarterback Mac Jones amidst the injury to Brock Purdy (shoulder). McCaffrey has wasted no time making a big impact in fantasy football, scoring at least 22.7 points (PPR) in each of his first two games this year. There's minimal competition for the 29-year-old in San Francisco, keeping him in the mid-range RB1 tier ahead of Week 3 versus the Arizona Cardinals.

Saturday, September 13, 4:45 AM

Kansas City Chiefs running back Isiah Pacheco will face the Philadelphia Eagles in Week 2. The defending Super Bowl champions defeated the Chiefs in their last matchup, and Pacheco only had seven rushing yards on three carries. The 26-year-old will have the chance to exact some revenge, but he must first overcome the timeshare he's in with Kareem Hunt. Pacheco and Hunt had the same number of opportunities in Week 1; both handled five carries and two catches on three targets. The former ultimately finished with more total yards, but it was not an impressive performance by either back. Pacheco did manage 5.0 yards per carry when given the opportunity, so maybe he can build on that efficiency with more usage. That said, the Eagles defense was one of the toughest in the league to run against last season, and that looks to be the case again this year. Pacheco will have his work cut out for him if he wants to carve out a larger role in the Kansas City backfield. Pacheco is ranked RB35 in our RotoBaller rankings this week, making him an RB3/Flex option. He'll be a tough player to trust this week.