Who Should I Start? Christian McCaffrey or James Cook

Saturday, December 27, 4:04 AM

San Francisco 49ers running back Christian McCaffrey has finished outside of the top ten at his position just twice in 2025. The heart of San Francisco's offense, McCaffrey leads the team in targets per game, is averaging 125.9 scrimmage yards per game, and has scored a touchdown in all but four of the 49ers' games this season. CMC's role in the passing game regressed in recent weeks until his 6-29-2 line on eight targets in Week 16. His target share may remain elevated in Week 17, as tight end George Kittle (ankle) is a game-time decision and Ricky Pearsall (knee, ankle) is questionable. McCaffrey has a welcome matchup against the Bears in Week 17. Chicago has allowed the sixth-most rushing yards per game and the second-most rushing yards before contact per attempt this year. As always, McCaffrey is in contention for an RB1 finish and should be locked into lineups for the final weekend of the fantasy football season.

Saturday, December 27, 10:18 AM

Buffalo Bills running back James Cook was dominant in Week 16's win over the Cleveland Browns, totaling 134 scrimmage yards and two touchdowns on just 17 touches. Cook has ascended once again in the 2025 season, jumping from 79.2 scrimmage yards per game in 2024 to 121.3 this season. He currently leads the NFL in rushing yards and ranks RB6 in PPR formats. The Bills host the Philadelphia Eagles in Week 17, who have allowed the eighth-most fantasy points to running backs this season. While star defensive tackle Jalen Carter will be active this week for the Eagles, Cook and the Bills are running the ball with ease, so fantasy managers should expect more dominance from the fourth-year back.