Who Should I Start? Curtis Samuel or Brandon Aiyuk

Monday, October 13, 6:21 PM

Buffalo Bills wide receiver Curtis Samuel (neck, ribs) is officially inactive for the Monday night contest on the road against the Atlanta Falcons, according to Adam Schefter of ESPN. In addition to Samuel, the Bills' offense will be missing tight end Dalton Kincaid (oblique) against what has been a much-improved Atlanta defense so far in 2025. The 29-year-old Samuel hasn't been on the fantasy radar to begin with, but his absence on Monday means less depth in the wideout corps for Buffalo behind Khalil Shakir, Keon Coleman, and Joshua Palmer. The Bills have their bye coming in Week 7, so hopefully Samuel will be ready to go for a Week 8 contest against the Carolina Panthers. Samuel has only been active for two games so far in 2025 and has caught three of his four targets for 35 yards and one touchdown. He had just one TD in 14 games a year ago for Buffalo and should remain on the waiver wire.

Wednesday, November 5, 6:04 PM

San Francisco 49ers head coach Kyle Shanahan said on Wednesday that he's "pretty confident" that wide receiver Brandon Aiyuk (knee) will play at some point this season, according to David Lombardi of The San Francisco Standard. However, the 49ers are still waiting for Aiyuk to "hit certain markers" on GPS speed measurements before opening his 21-day practice window. Once Aiyuk returns to practice, the team will have 21 days to officially activate him from the Physically Unable to Perform list. Despite the optimism, reports on Monday suggested that the 27-year-old former first-rounder wasn't close to a return to practice, so fantasy managers who have been stashing Aiyuk all year shouldn't get their hopes up. Aiyuk suffered a torn ACL and MCL in Week 7 of last year and probably won't be back in games for the 49ers until December.