Who Should I Start? Darius Slayton or Andy Isabella

Saturday, October 3, 11:50 AM

Indianapolis Colts wide receiver Darius Slayton will make his team debut on Sunday, and he could immediately step into an elevated role. Slayton was originally signed to take the roster spot of Alec Pierce (heel) on injured reserve, but he hasn't earned an offensive snap yet. That should change in Week 4, as the Colts will be without both Pierce and Keenan Allen (groin). There's a reasonable path for Slayton to occupy the No. 2 role on the depth chart behind Josh Downs. The jury is still out on whether the Colts' offense can support two fantasy-relevant receivers at once, but we'd feel decent about his outlook against the Washington Commanders if he does indeed operate as the No. 2 receiver behind Downs. This is certainly a very enticing matchup for Slayton; entering Week 4, the Commanders had allowed the most fantasy points to wide receivers in 2026. Managers who are in deeper leagues and need a WR3/flex replacement should consider streaming Slayton this week.