Who Should I Start? Isaac Guerendo or TreVeyon Henderson

Monday, January 6, 10:31 PM

An MRI exam on Monday morning revealed that San Francisco 49ers rookie running back Isaac Guerendo (ankle, knee) suffered an MCL sprain and an ankle sprain in the loss to the division-rival Arizona Cardinals on Sunday in the Week 18 regular-season finale, according to a source. Guerendo will have plenty of time to heal up in the offseason, and the best news is that he didn't suffer any damage to his ACL. Both of the injuries are to his left leg. The 24-year-old fourth-round pick didn't see much of an opportunity in 2024 until late in the season when both Christian McCaffrey (knee) and Jordan Mason (ankle) were ruled out for the year, but when he did get his chances, he was pretty effective out of the Niners' backfield. Guerendo finished with 5.0 yards per carry for 420 yards and four TDs on 84 carries through 16 games. He should serve as valuable insurance for McCaffrey in 2025.

Monday, April 28, 11:28 PM

The New England Patriots view rookie running back TreVeyon Henderson as "a three-down back and a really good complement," according to general manager Eliot Wolf. "He's a threat with the ball in his hands, speed to take at the distance anytime he touches it." The Patriots selected the former Ohio State product with the 38th overall pick in the second round of last week's NFL draft as the fourth RB off the board. The 22-year-old will most likely split backfield touches with Rhamondre Stevenson to begin his first year in the NFL, similar to what he did with the Buckeyes last year with Quinshon Judkins. The 5-foot-10, 202-pound 22-year-old has the ability to do damage with long plays anytime the ball is in his hands, giving New England another dynamic playmaker behind young quarterback Drake Maye. At the very least, Henderson will be a handcuff option for fantasy managers that take the chance on Stevenson.