Who Should I Start? Isaac Guerendo or TreVeyon Henderson

Tuesday, October 21, 9:16 PM

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.

Wednesday, November 5, 3:21 PM

New England Patriots running back TreVeyon Henderson played a season-high (and, thus, career-high) 75 percent of the offensive snaps during Week 9 against the Atlanta Falcons. The rookie took advantage of Rhamondre Stevenson (toe) being sidelined and tallied 14 carries, 55 rushing yards, four receptions, and 32 receiving yards. While he did earn the bulk of the backfield snaps, carries, and targets, he shared more touches than expected with Terrell Jennings, who had 11 carries and one catch. Nevertheless, the backfield mostly belonged to Henderson, and we could see this trend continue in Week 10 against the Tampa Bay Buccaneers. Stevenson did not practice on Wednesday, leaving Henderson to handle first-team reps as the Patriots prepare for the Bucs. Stevenson will likely need to get on the field in some capacity on Thursday or Friday to have a chance to play in Week 10. Even if Stevenson does suit up, he's not a lock to start; his 3.4 yards per carry and three lost fumbles in 2025 are concerning, and Henderson's decent showing last week could be enough for the Patriots to give him the keys to the backfield. To make a long story short, Henderson will continue to face competition from Stevenson or Jennings no matter what, but the rookie out of Ohio State is one step closer to taking full control of the New England backfield. At the moment, he ranks as a low-end RB2 in redraft leagues.