Who Should I Start? Isaac Guerendo or TreVeyon Henderson

Tuesday, October 21, 9:16 PM

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.

Sunday, November 30, 7:34 AM

New England Patriots running back TreVeyon Henderson cemented himself as the team's lead back while fending off Rhamondre Stevenson last Sunday, and in doing so, he also strengthened his position as a low-end RB1 in fantasy football. Henderson continues to find himself in the must-start range ahead of Monday Night Football against the New York Giants in Week 13. The rookie played 65% of the snaps last week, holding Stevenson to just seven touches for 10 yards. Meanwhile, Henderson had 18 carries for 66 rushing yards, plus three catches for an additional 15 receiving yards. The Ohio State product didn't find the end zone, but he did have five touchdowns over his previous two games. In four games since taking over as the Patriots' primary ball carrier, he is the third-highest-scoring running back in PPR leagues. He'll have a great chance to strengthen his fantasy value this week against the Giants, who have allowed the second-most fantasy points to opposing running backs in 2025. Henderson ranks as the overall RB9 in this week's RotoBaller fantasy football rankings.