Who Should I Start? James Conner or Isaac Guerendo

Thursday, May 29, 1:04 PM

Arizona Cardinals running back James Conner (knee) took part in voluntary organized team activities on Wednesday. "I'm ready," Conner said. "We ain't doing this forever." Conner injured his right knee in Week 16 of last year and had six touches before being pulled in Week 17. The Cardinals placed him on Injured Reserve for the Week 18 regular-season finale, but the 30-year-old veteran appears to be fine now and ready to go for the start of the 2025 season this fall. He racked up a career-high 1,518 scrimmage yards on 236 carries while catching 47 of 55 targets in 2024. It was the healthiest Conner had been in his career, so fantasy managers definitely should expect some more missed time given his age and physical running style. For now, he's still being considered a workhorse back in Arizona, but more injuries could give Trey Benson more of a role eventually.

Monday, January 6, 10:31 PM

An MRI exam on Monday morning revealed that San Francisco 49ers rookie running back Isaac Guerendo (ankle, knee) suffered an MCL sprain and an ankle sprain in the loss to the division-rival Arizona Cardinals on Sunday in the Week 18 regular-season finale, according to a source. Guerendo will have plenty of time to heal up in the offseason, and the best news is that he didn't suffer any damage to his ACL. Both of the injuries are to his left leg. The 24-year-old fourth-round pick didn't see much of an opportunity in 2024 until late in the season when both Christian McCaffrey (knee) and Jordan Mason (ankle) were ruled out for the year, but when he did get his chances, he was pretty effective out of the Niners' backfield. Guerendo finished with 5.0 yards per carry for 420 yards and four TDs on 84 carries through 16 games. He should serve as valuable insurance for McCaffrey in 2025.