Who Should I Start? James Conner or Isaac Guerendo


Week 4 Projections

Fant.
Pts.
Rush.
Yds.
Rush
TD
Rec. Rec.
Yds.
Rec
TD
0.0 0.0 0.0 0.0 0.0 0.0

James Conner News

James Conner Progressing Without Return Timeline

Friday, October 2, 12:05 PM

Arizona Cardinals running back James Conner (foot) is progressing, but the team still isn't putting a date on his return. Head coach Mike LaFleur said Conner is doing well and reiterated that Arizona wants him back when he can perform at his normal level, not simply when he's able to get through a practice. Conner opened the season on injured reserve while continuing his recovery from the right foot injury that ended his 2025 season in Week 3. He can become eligible to practice next week after serving the required four-game absence, though the Cardinals have not said they will immediately open his 21-day window. That matters with Jeremiyah Love emerging as Arizona's lead back and Tyler Allgeier still involved. Conner is coming off back-to-back 1,000-yard rushing seasons in 2023 and 2024, but fantasy managers should treat him as a deeper-league IR stash until there is a clearer return date and role.


Week 4 Projections

Fant.
Pts.
Rush.
Yds.
Rush
TD
Rec. Rec.
Yds.
Rec
TD
0.0 0.0 0.0 0.0 0.0 0.0

Isaac Guerendo News

Isaac Guerendo Placed on PUP List, Out for Four Games

Sunday, August 30, 3:42 PM

San Francisco 49ers running back Isaac Guerendo (pectoral) has been placed on the Physically Unable to Perform list, according to Jeremy Fowler of ESPN.com. He will now miss at least four games, keeping him sidelined through the entire month of September. At the earliest, he can return in Week 5 against the Seattle Seahawks on October 11. Guerendo did not play an offensive snap last year, but he was heavily involved as the primary backup to Christian McCaffrey in 2024. That year, he tallied 420 rushing yards, 152 receiving yards, and four touchdowns. There's a chance that Guerendo could return to that level of production (and his role as the No. 2 ball-carrier) once he's healthy again, but in the meantime, Kaelon Black and Jordan James will round out the depth chart behind McCaffrey.


James Conner vs. Isaac Guerendo

Still trying to decide between Conner and Guerendo? Check on the latest news to make sure both players are active and healthy. Our PPR projections show that James Conner is projected to score 0.0 points this week while Isaac Guerendo is projected to score 0.0 points.