Who Should I Start? James Conner or Isaac Guerendo

Thursday, May 29, 1:04 PM

Arizona Cardinals running back James Conner (knee) took part in voluntary organized team activities on Wednesday. "I'm ready," Conner said. "We ain't doing this forever." Conner injured his right knee in Week 16 of last year and had six touches before being pulled in Week 17. The Cardinals placed him on Injured Reserve for the Week 18 regular-season finale, but the 30-year-old veteran appears to be fine now and ready to go for the start of the 2025 season this fall. He racked up a career-high 1,518 scrimmage yards on 236 carries while catching 47 of 55 targets in 2024. It was the healthiest Conner had been in his career, so fantasy managers definitely should expect some more missed time given his age and physical running style. For now, he's still being considered a workhorse back in Arizona, but more injuries could give Trey Benson more of a role eventually.

Friday, June 6, 12:54 PM

San Francisco 49ers running back Isaac Guerendo (ankle, knee) has been taking part in voluntary organized team activities this spring after injuring his MCL and spraining his ankle in the Week 18 regular-season finale last year. Guerendo, a fourth-round pick (129th overall) in 2024, should be a full-go for the start of mandatory minicamp on June 10. All-Pro Christian McCaffrey (knee) is also back and ready to roll after missing the majority of the 2024 campaign, so Guerendo will enter the 2025 season as the backup, but Jordan Mason was traded to the Minnesota Vikings and Elijah Mitchell left in free agency. The 24-year-old Guerendo had 5.0 yards per carry on his 84 rushing attempts last year for 420 yards and four touchdowns in 16 games (three starts), adding 15 catches for 152 yards through the air. Consider him a high-upside handcuff behind the injury-prone CMC.