Who Should I Start? James Cook or Ashton Jeanty

Sunday, September 28, 9:47 PM

Buffalo Bills running back James Cook posted another huge game in Week 4 in his team's 31-19 victory over the New Orleans Saints. Cook recorded 117 yards and a touchdown on 22 carries and added three catches for 18 yards for good measure as well. The 26-year-old has now logged 401 rushing yards and five touchdowns on 75 carries and 12 receptions for 89 yards through his first four games of 2025. He dominated backfield touches in Week 4, earning 22 out of 24 rush attempts by running backs for Buffalo against New Orleans. As long as he's healthy, Cook is a must-start fantasy running back.

Sunday, September 28, 8:25 PM

Las Vegas Raiders running back Ashton Jeanty rushed for 138 yards and one touchdown on 21 carries during Sunday's Week 4 loss to the Chicago Bears. He also caught two passes for 17 receiving yards and two receiving touchdowns. The rookie set several career-bests in his fourth NFL game, including most carries, most rushing yards, most yards per carry, most receiving yards, and most touchdowns. After three relatively underwhelming weeks, it was exciting to see things finally click for Jeanty, who was regarded as one of the top running back prospects of this decade. He'll rank as an RB2 with RB1 upside heading into Week 5 against the Indianapolis Colts.