Who Should I Start? James Cook or Chase Brown

Sunday, September 28, 9:47 PM

Buffalo Bills running back James Cook posted another huge game in Week 4 in his team's 31-19 victory over the New Orleans Saints. Cook recorded 117 yards and a touchdown on 22 carries and added three catches for 18 yards for good measure as well. The 26-year-old has now logged 401 rushing yards and five touchdowns on 75 carries and 12 receptions for 89 yards through his first four games of 2025. He dominated backfield touches in Week 4, earning 22 out of 24 rush attempts by running backs for Buffalo against New Orleans. As long as he's healthy, Cook is a must-start fantasy running back.

Saturday, September 27, 12:35 PM

Cincinnati Bengals running back Chase Brown is coming off a quality year. Unfortunately, that success didn't follow him into the 2025 campaign. Through the first three weeks, the 25-year-old has 47 attempts. However, he's only amassed 93 yards for a miserable 2.0 yards per carry. With that said, Brown can't necessarily take all of the blame for his inefficiency, considering the entire offense has struggled. That was even the case when Joe Burrow (toe) was on the field. The Bengals suffered a blowout loss to the Vikings in Week 3 after starting the season with a 2-0 record, so the club will look to get on track versus the Denver Broncos on Monday night. Without question, Brown has plenty of upside for managers in any format. Still, until things on the offensive side of the ball are sorted out, Brown's presence in fantasy lineups in Week 4 (and beyond) is not without risk.