Who Should I Start? James Cook or Isaac Guerendo
Week 1 Projections
| Fant. Pts. |
Rush. Yds. |
Rush TD |
Rec. | Rec. Yds. |
Rec TD |
|---|---|---|---|---|---|
| 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
James Cook News
Thursday, April 30, 8:28 AM
Although Buffalo Bills running back James Cook was a highly productive player in his first three NFL seasons, he took his game to a new level in 2025. Across 17 games, the 26-year-old recorded 1,912 yards from scrimmage and 14 touchdowns on 342 touches. Cook has always been an extremely efficient rusher, but the Bills coaching staff finally entrusted him with a true RB1 workload in 2025. Cook averaged 20.1 touches per game last season, well beyond his previous career-high of 16.5 touches per game in 2023. While the Bills shook up their coaching staff heading into 2026, former offensive coordinator Joe Brady is now the head coach in Buffalo and appears unlikely to drastically alter Cook's usage. Entering his age-27 season with an excellent offensive environment around him in Buffalo, Cook profiles as an elite dynasty running back.
Week 1 Projections
| Fant. Pts. |
Rush. Yds. |
Rush TD |
Rec. | Rec. Yds. |
Rec TD |
|---|---|---|---|---|---|
| 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
Isaac Guerendo News
Tuesday, May 5, 9:37 AM
The Athletic's Vic Tafur writes that San Francisco 49ers running back Isaac Guerendo, who was a fourth-round pick in 2024, "seems like he is buried" and will be "looking for a new team." The 49ers say that they will be looking to give Christian McCaffrey fewer touches in 2026, which is why they drafted rookie Kaelon Black in the third round. The Niners also have Jordan James, Patrick Taylor Jr., and Sincere McCormick in their RB room, leaving little playing time left for Guerendo. Black is expected to compete with James for the No. 2 role, so the 25-year-old Guerendo figures to be the RB4 in San Fran right now, at best. Guerendo carried the ball 84 times for 420 yards (5.0 yards per carry) and four touchdowns while adding 15 receptions for 152 yards through the air in 16 regular-season games (three starts), but he didn't see a single carry in 14 regular-season contests in Year 2 in 2025. He appears to be the odd-man out, making him a cut candidate in dynasty/keeper leagues going into the 2026 campaign.
James Cook vs. Isaac Guerendo
Still trying to decide between Cook and Guerendo? Check on the latest news to make sure both players are active and healthy. Our PPR projections show that James Cook is projected to score 0.0 points this week while Isaac Guerendo is projected to score 0.0 points.
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