Who Should I Start? James Cook or Isaac Guerendo

Sunday, December 14, 9:42 PM

Buffalo Bills running back James Cook put up a dominant performance in his team's critical Week 15 win over its division rival, the New England Patriots, on Sunday. Cook recorded 22 carries for 107 yards and two touchdowns, and two receptions for four yards and a score. The 26-year-old has now racked up 1,686 yards from scrimmage and 12 touchdowns on 302 touches across 14 games this season. Cook has topped 100 scrimmage yards in five straight games and 11 out of 14 total contests in 2025. He also continues to dominate backfield touches in Buffalo, logging 22 of the team's 26 rushing attempts by running backs in Week 15. Cook profiles as a must-start fantasy running back heading into a Week 16 matchup against the Cleveland Browns.

Tuesday, October 21, 9:16 PM

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.