Who Should I Start? James Cook or Isaac Guerendo

Sunday, November 16, 10:34 PM

Buffalo Bills running back James Cook wasn't very efficient on the ground in Sunday's 44-32 win over the visiting Tampa Bay Buccaneers in Week 11, but he still managed to go over 100 scrimmage yards while securing his first receiving touchdown of the year. Cook had 16 rushing attempts for 48 yards on the ground (3.0 yards per carry) while adding three catches on three targets for a season-high 66 yards through the air and his first receiving TD (eighth total in 2025). The 26-year-old had a tough time finding space to run on Sunday against a stout Buccaneers defensive front, but he salvaged his day for fantasy managers by contributing as a pass-catcher, finishing as Buffalo's second leading receiver. Cook's TD came on a 25-yard reception. He's a must-start in all fantasy formats, but Cook might need more contributions as a pass-catcher again in Week 12 in a tough matchup on the ground against the Houston Texans on Thursday Night Football.

Tuesday, October 21, 9:16 PM

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.