| Age | 25 |
|---|---|
| Birthdate | June 28, 2000 |
| Height | 6'0" |
| Weight | 221 lb |
| College | Louisville | |
|---|---|---|
| Year | 2024 | |
| Pick | Round: 4, Overall: 129 | |
| Team | SF |
San Francisco 49ers running back Isaac Guerendo recorded 572 yards from scrimmage and four touchdowns on 99 total touches as a rookie in 2024. However, through five games in 2025, the 25-year-old has not played a single offensive snap. Guerendo is buried on the 49ers running back depth chart behind Christian McCaffrey and Brian Robinson Jr. As long as both McCaffrey and Robinson Jr. remain healthy, it appears unlikely that Guerendo's role in San Francisco's offense is going to change. Guerendo maintains some appeal in dynasty leagues, but he should remain off the radar of redraft fantasy managers for the time being.
Oct. 8, 2025 11:50 AM EST
| YEAR | TM | GM | Rushing | Receiving | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ATT | YDS | YPC | TD | FUM | REC | TGT | % | YDS | TD | YPC | |||
| 2024 | SF | 16 | 82 | 415 | 5.1 | 4 | 1 | 15 | 16 | 93.8 | 152 | 0 | 10.1 |
| 2025 | SF | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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