Isaac Guerendo

San Francisco 49ers
Running Back #31

Personal

Age	25
Birthdate	June 28, 2000
Height	6'0"
Weight	221 lb

Draft

College	Louisville
Year	2024
Pick	Round: 4, Overall: 129
Team	SF

Fantasy Value

Week 1 Projections
Carries	Yards	Touchdowns
5.075	20.755	0.265

You can see where those projections compare to other RBs in our Running Back Rankings.

Player News

Isaac Guerendo: Isaac Guerendo Taking Part in OTAs

San Francisco 49ers running back Isaac Guerendo (ankle, knee) has been taking part in voluntary organized team activities this spring after injuring his MCL and spraining his ankle in the Week 18 regular-season finale last year. Guerendo, a fourth-round pick (129th overall) in 2024, should be a full-go for the start of mandatory minicamp on June 10. All-Pro Christian McCaffrey (knee) is also back and ready to roll after missing the majority of the 2024 campaign, so Guerendo will enter the 2025 season as the backup, but Jordan Mason was traded to the Minnesota Vikings and Elijah Mitchell left in free agency. The 24-year-old Guerendo had 5.0 yards per carry on his 84 rushing attempts last year for 420 yards and four touchdowns in 16 games (three starts), adding 15 catches for 152 yards through the air. Consider him a high-upside handcuff behind the injury-prone CMC.

Jun. 6, 2025 12:54 PM EST