Isaac Guerendo

San Francisco 49ers
Running Back #31

Personal

Age	26
Birthdate	June 28, 2000
Height	6'0"
Weight	221 lb

Draft

College	Louisville
Year	2024
Pick	Round: 4, Overall: 129
Team	SF

Fantasy Value

Week 1 Projections
Carries	Yards	Touchdowns
1.42	6.14	0.04

You can see where those projections compare to other RBs in our Running Back Rankings.

Player News

Isaac Guerendo: Isaac Guerendo Appears to Be Progressing in Recovery

San Francisco 49ers running back Isaac Guerendo (pectoral) appears to be making progress in his recovery from a torn pectoral muscle, according to Nick Wagoner of ESPN. Guerendo suffered the injury while lifting weights during the offseason and opened training camp on the active/physically unable to perform list. Kyle Shanahan said in May that the third-year back could return near the end of camp, and Wagoner's observation is a welcome sign, though Guerendo has not yet been cleared to practice. He appeared in 14 games last season but played exclusively on special teams after rushing for 420 yards and four touchdowns as a rookie. Christian McCaffrey remains the clear starter, while rookie Kaelon Black has gained valuable reps with Guerendo sidelined and Jordan James dealing with fractured ribs. Guerendo still has time to work his way back into the competition for a reserve role, but his fantasy value will remain limited until he returns to practice and shows where he stands in the backfield.

Aug. 2, 2026 11:29 AM EST