San Francisco 49ers running back Isaac Guerendo has yet to see an offensive snap in 2025, and there is little reason to expect that to change in Week 4. Christian McCaffrey is the team's unquestioned starter, and Brian Robinson Jr. has the second position on the depth chart locked down. The team's official depth chart lists both Guerendo and rookie Jordan James as the third-string running back, raising the question of which of the two would be given an opportunity in the backfield should the need arise. In the meantime, Guerendo has been relegated to kick return duty. Through three games, he has taken back four kicks for a grand total of 82 yards. Until an injury shakes up the depth chart, Guerendo has no place on fantasy football rosters.
Sep 27, 2025 5:08 AM EST
San Francisco 49ers running back Isaac Guerendo entered the 2025 season as a prime handcuff for fantasy managers who were looking to score Christian McCaffrey at a discount early in drafts. However, Guerendo's fantasy value took a massive hit when the Niners acquired Brian Robinson Jr. from the Washington Commanders. B-Rob has been McCaffrey's backup through two weeks, relegating Guerendo to a distant RB3 role. In the Week 2 win over the New Orleans Saints, the 25-year-old didn't play a single snap on offense, with all 17 of his snaps coming on special teams. Guerendo averaged a healthy 5.0 yards per carry on 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) as a rookie in 2024 when CMC was bothered by injuries, but currently, he's well off the fantasy radar in single-year leagues going into Week 3 against the division-rival Arizona Cardinals.
Sep 17, 2025 12:37 PM EST
Second-year running back Isaac Guerendo opens the season third on the 49ers' depth chart, though he may already see more action than originally anticipated. Christian McCaffrey (calf) popped up on the team's injury report this week and is tagged as questionable for San Francisco's Week 1 matchup against the Seahawks. Guerendo's only route to fantasy relevance relies on CMC sitting. If that does happen, then he can be seen as a deep-league flex candidate. Brian Robinson Jr. will likely draw the start, but Guerendo made his mark in 2024 in similar circumstances and is a potential RB4/5 pending McCaffrey's status.
Sep 6, 2025 6:51 AM EST
San Francisco 49ers running back Isaac Guerendo (shoulder) played at less than 100 percent during Saturday's preseason contest. Guerendo started the game, but re-aggravated his shoulder injury in the first quarter. Luckily, Guerendo was able to return to the game after getting looked at on the sideline. At the moment, all signs point to Guerendo being available for the season opener. However, his fantasy value is going to take a serious hit with Brian Robinson Jr. taking over as the RB2 in San Francisco. Guerendo probably won't see significant snaps unless someone gets hurt in the backfield.
Aug 24, 2025 8:27 AM EST
Running back Christian McCaffrey is the San Francisco 49ers' unquestioned No. 1 RB when he's healthy, but Cam Inman of the Bay Area News Group thinks that Isaac Guerendo is still the projected RB2 behind CMC despite Friday's trade acquisition of Brian Robinson Jr, presuming that B-Rob isn't fast-tracked over the next two weeks. Guerendo resumed practicing this week after two weeks off from a shoulder dislocation, so he should be ready for Week 1 of the regular season against the division-rival Seattle Seahawks on Sunday, Sept. 7. Although the 25-year-old Guerendo figures to be the RB2 to open the year, it's entirely possible that Robinson leaps him on the RB depth chart eventually. The trade for B-Rob definitely is a hit to Guerendo's potential upside if CMC gets hurt again, too. Early on, Robinson will most likely be more of a short-yardage/goal-line power back in his new home.
Aug 22, 2025 1:06 PM EST
San Francisco 49ers running back Isaac Guerendo (shoulder) returned to training camp practice on Tuesday and was pretty active, according to Matt Maiocco of NBC Sports Bay Area. Guerendo will have more opportunities for reps with both Patrick Taylor Jr. (shoulder) and Corey Kiner (ankle) both injured. The 25-year-old missed a couple of weeks at camp with a shoulder injury but is now back in time to be ready for the Week 1 regular-season opener in two weeks. It remains to be seen if the Niners will play him in the preseason finale against the Los Angeles Chargers on Saturday. Guerendo, a fourth-rounder last year, had a healthy 5.0 yards per carry and 420 rushing yards on 84 carries in 16 games (three starts) in his first season in the NFL. He's primarily a handcuff option for the injury-prone Christian McCaffrey, but if CMC misses more time with injury, Guerendo would be an every-week fantasy starter.
Aug 19, 2025 5:15 PM EST
San Francisco 49ers running back Isaac Guerendo (shoulder) is expected to miss a couple of weeks, according to Matt Maiocco of NBC Sports. Guerendo will miss time after getting injured during Saturday's training camp practice. While the 25-year-old still has time to get ready for the start of the regular season, he will miss important reps during practice and the preseason as he gets ready to serve as Christian McCaffrey's primary backup in 2025. With Guerendo now out for a few weeks, it will give rookie Jordan James more opportunities to run with the first-team offense when CMC needs a breather. In addition to James, Patrick Taylor Jr. and Ameer Abdullah should see more work in practices. When healthy, Guerendo's raw athletic abilities make him an intriguing handcuff if you take the leap on McCaffrey.
Aug 4, 2025 3:26 PM EST
San Francisco 49ers running back Isaac Guerendo (ankle, knee) has been taking part in voluntary organized team activities this spring after injuring his MCL and spraining his ankle in the Week 18 regular-season finale last year. Guerendo, a fourth-round pick (129th overall) in 2024, should be a full-go for the start of mandatory minicamp on June 10. All-Pro Christian McCaffrey (knee) is also back and ready to roll after missing the majority of the 2024 campaign, so Guerendo will enter the 2025 season as the backup, but Jordan Mason was traded to the Minnesota Vikings and Elijah Mitchell left in free agency. The 24-year-old Guerendo had 5.0 yards per carry on his 84 rushing attempts last year for 420 yards and four touchdowns in 16 games (three starts), adding 15 catches for 152 yards through the air. Consider him a high-upside handcuff behind the injury-prone CMC.
Jun 6, 2025 12:54 PM EST
An MRI exam on Monday morning revealed that San Francisco 49ers rookie running back Isaac Guerendo (ankle, knee) suffered an MCL sprain and an ankle sprain in the loss to the division-rival Arizona Cardinals on Sunday in the Week 18 regular-season finale, according to a source. Guerendo will have plenty of time to heal up in the offseason, and the best news is that he didn't suffer any damage to his ACL. Both of the injuries are to his left leg. The 24-year-old fourth-round pick didn't see much of an opportunity in 2024 until late in the season when both Christian McCaffrey (knee) and Jordan Mason (ankle) were ruled out for the year, but when he did get his chances, he was pretty effective out of the Niners' backfield. Guerendo finished with 5.0 yards per carry for 420 yards and four TDs on 84 carries through 16 games. He should serve as valuable insurance for McCaffrey in 2025.
Jan 6, 2025 10:31 PM EST
Per head coach Kyle Shanahan, San Francisco 49ers running back Isaac Guerendo (knee, ankle) has likely picked up an MCL sprain but will undergo more testing on Monday to confirm the severity of the injury. Matt Barrows of The Athletic reported the news. That'd be a best-case scenario for the rookie, who was carted off in the first quarter of his team's 47-24 loss to the Arizona Cardinals. Guerendo was bent up awkwardly not even two minutes into the contest and quickly ruled out afterward. San Francisco has been unable to keep a running back healthy this season, as they've had four suffer serious injuries. It's been a disappointing year for the 49ers -- a team with Super Bowl aspirations that won't make a playoff appearance in 2024 after a campaign riddled with injuries. They'll hope for better in 2025.
Jan 5, 2025 10:07 PM EST
San Francisco 49ers running back Isaac Guerendo (knee, ankle) exited during the first quarter of Sunday's Week 18 game against the Arizona Cardinals. He has been ruled out for the remainder of the contest. It was an ugly scene in Arizona as Guerendo's leg bent awkwardly while he was being tackled. He was in noticeable pain while being carted off the field, and the 49ers ruled him out with both knee and ankle injuries very quickly. He finishes Sunday's contest with two carries for five yards. All in all, he registered 420 rushing yards, 152 receiving yards, and four total touchdowns while splitting time as a depth option and starter this season. Patrick Taylor Jr. will lead the 49ers' backfield for the remainder of Sunday's contest.
Jan 5, 2025 4:47 PM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) is off the injury report and ready to roll for a Week 18 matchup with the Cardinals in Arizona. Last week at home versus Detroit, Guerendo took just nine carries for 34 yards but snagged all four targets in the passing game for 65 yards. Arizona's defense represents a favorable opportunity for Guerendo to finish his first NFL campaign on a high note -- they have allowed the 10th-most half-PPR points per game (21.9). Last week, they allowed 14.7 points to Kyren Williams of the Los Angeles Rams. With the 49ers having been eliminated from playoff contention weeks ago and playing their final game of 2024, head coach Kyle Shanahan should give Guerendo his classic heavy lead-back usage while assessing Guerendo's role in 2025. This could be especially true with the 49ers injury issues -- backup Joshua Dobbs is starting for an injured Brock Purdy (right elbow), wideout Deebo Samuel Sr. (rib, wrist) is out, and tight end George Kittle (ankle, hamstring) is questionable. Guerendo is a back-end RB1 in Week 18.
Jan 3, 2025 10:24 PM EST
San Francisco 49ers rookie running back Isaac Guerendo had a useful fantasy day during a 40-34 loss to the Detroit Lions on Monday night. The former high school wide receiver took nine carries for just 34 yards but saved his day through the air by catching all four of his targets for 65 yards. With most fantasy leagues in the books after Monday night, it's fair to say that Guerendo comported himself well in his rookie season by flashing the speed, receiving chops, and scheme fit that caused the 49ers to trade up and select him in the fourth round. Guerendo figures to draw another start while vying for his fifth 10-plus-point half-PPR performance in Week 18's meaningless game in Arizona.
Dec 31, 2024 12:32 AM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) will return from a one-week absence when the team hosts the Detroit Lions on Monday night. Before missing last week's contest against Miami, Guerendo took 16 carries for 57 yards and caught four of four targets for 18 yards versus the Rams. The week before that, the fourth-rounder out of Louisville popped off for 25.8 half-PPR points against Chicago. Detroit has a quality rush defense, having allowed the fourth-fewest points per game to opposing running backs this season. Most recently, they held the Bears to 59 yards and no touchdowns on the ground. It's worth noting that San Francisco is down to their third-string left tackle and could be missing starting right tackle Colton McKivitz (knee), who is questionable. Consider Guerendo a back-end RB2 in Week 17.
Dec 28, 2024 10:37 PM EST
According to Adam Schefter of ESPN, San Francisco 49ers rookie running back Isaac Guerendo (hamstring/foot) is expected to play on Monday evening. The rookie running back was unable to suit up last weekend and has logged two limited practice sessions earlier this week. Fantasy managers should keep a close eye on his status on Saturday's final injury report as a full practice session may help him avoid an injury designation. While sidelined, Patrick Taylor Jr. was given the starting nod and tallied just 24 yards on eight attempts. Guerendo has averaged a solid 19.1 PPR points per game during Weeks 14 and 15 and should be viewed as an RB2 if he is able to suit up on Monday, despite facing a tough Detroit run defense that has allowed the fourth-fewest PPR to the position.
Dec 28, 2024 3:04 PM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) was limited in practice for the second straight day this week on Friday. Guerendo, who did not play in the Week 16 loss to the Miami Dolphins, may need to upgrade to a full practice on Saturday to avoid carrying a questionable designation into Monday night's Week 17 showdown in what will be a rematch of last year's NFC Championship against the Detroit Lions. If the 24-year-old back is feeling good enough to play on Monday, he should return to lead-back duties for San Fran, albeit in a bad matchup. Although they are pretty banged up now, the Lions defense has allowed the fourth-fewest half-PPR points per game to RBs in 15 games in 2024. However, in the last five weeks, they've been in the middle of the pack in that same category. If Guerendo is active in Week 17, he'll be a low-end RB2/high-end RB3/flex in fantasy.
Dec 27, 2024 7:12 PM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) is limited in the team's first practice of the week on Thursday. Guerendo is dealing with two injuries and was unable to play in the Week 16 loss to the Miami Dolphins. It's good news that the 24-year-old is back on the practice field, but he might need to upgrade to a full practice in the next two days to avoid a questionable tag heading into a Monday night game against the Detroit Lions. Guerendo will operate as San Fran's lead back if he's available this week, but the problem is it might not be worth the risk leaving him in starting lineups for championship week in fantasy if he's uncertain to play on Monday night. Additionally, the matchup against Detroit's defense is not a friendly one for fantasy purposes. If Guerendo misses a second straight game, Patrick Taylor Jr. would be in line for a second straight start.
Dec 26, 2024 3:27 PM EST
San Francisco 49ers running back Isaac Guerendo (foot, hamstring) is expected to get back on the practice field on Thursday, according to head coach Kyle Shanahan. The rookie back is dealing with multiple injuries that kept him out of last week's game against the Miami Dolphins. His absence resulted in the 49ers using a committee approach in the backfield with two other backs sidelined as well. The hope is that Guerendo will be able to return for the Week 17 matchup against the Detroit Lions. He could be a low-end RB2 if he's healthy in time for that contest.
Dec 23, 2024 9:33 PM EST
According to Matt Maiocco of NBC Bay Area, San Francisco 49ers running back Isaac Guerendo (hamstring) has been ruled out for Sunday's match against the Miami Dolphins. Guerendo was unable to participate in any team practices this week. He entered his Week 14 game with a foot injury and then left it with a hamstring concern. Fantasy managers should closely monitor his status next week as he may be in danger of missing more time. As a result, fantasy managers should expect Patrick Taylor Jr. to lead a depleted San Francisco backfield on Sunday. Throughout the season, he has tallied 50 yards on 14 attempts and brought in one of his two targets for 12 yards. Taylor should be viewed as a high-floor flex option this weekend facing a Miami rushing defense that has allowed the 12th-most PPR points to opposing RBs this season.
Dec 20, 2024 4:37 PM EST
San Francisco 49ers rookie running back Isaac Guerendo (hamstring) is dealing with a hamstring injury and is unlikely to play in Week 16 versus the hosting Miami Dolphins at Hard Rock Stadium on Sunday, according to a source. The Niners' backfield has just been decimated by injuries this year, with Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring) already out for the season. Guerendo handled himself nicely as the starting RB for San Fran the last two games, carrying the ball 31 times for 135 yards (4.35 yards per carry) and two touchdowns while catching all six of his targets for another 68 yards. Fantasy managers won't have him available for semifinal matchups this week, though, with Patrick Taylor Jr. likely sharing rushing attempts with receiver Deebo Samuel Sr. against Miami. Israel Abanikanda will also likely be available as a backup. Taylor will be an RB3/flex, at best, in fantasy.
Dec 19, 2024 12:25 PM EST
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