An MRI exam on Monday morning revealed that San Francisco 49ers rookie running back Isaac Guerendo (ankle, knee) suffered an MCL sprain and an ankle sprain in the loss to the division-rival Arizona Cardinals on Sunday in the Week 18 regular-season finale, according to a source. Guerendo will have plenty of time to heal up in the offseason, and the best news is that he didn't suffer any damage to his ACL. Both of the injuries are to his left leg. The 24-year-old fourth-round pick didn't see much of an opportunity in 2024 until late in the season when both Christian McCaffrey (knee) and Jordan Mason (ankle) were ruled out for the year, but when he did get his chances, he was pretty effective out of the Niners' backfield. Guerendo finished with 5.0 yards per carry for 420 yards and four TDs on 84 carries through 16 games. He should serve as valuable insurance for McCaffrey in 2025.
Jan 6, 2025 10:31 PM EST
Per head coach Kyle Shanahan, San Francisco 49ers running back Isaac Guerendo (knee, ankle) has likely picked up an MCL sprain but will undergo more testing on Monday to confirm the severity of the injury. Matt Barrows of The Athletic reported the news. That'd be a best-case scenario for the rookie, who was carted off in the first quarter of his team's 47-24 loss to the Arizona Cardinals. Guerendo was bent up awkwardly not even two minutes into the contest and quickly ruled out afterward. San Francisco has been unable to keep a running back healthy this season, as they've had four suffer serious injuries. It's been a disappointing year for the 49ers -- a team with Super Bowl aspirations that won't make a playoff appearance in 2024 after a campaign riddled with injuries. They'll hope for better in 2025.
Jan 5, 2025 10:07 PM EST
San Francisco 49ers running back Isaac Guerendo (knee, ankle) exited during the first quarter of Sunday's Week 18 game against the Arizona Cardinals. He has been ruled out for the remainder of the contest. It was an ugly scene in Arizona as Guerendo's leg bent awkwardly while he was being tackled. He was in noticeable pain while being carted off the field, and the 49ers ruled him out with both knee and ankle injuries very quickly. He finishes Sunday's contest with two carries for five yards. All in all, he registered 420 rushing yards, 152 receiving yards, and four total touchdowns while splitting time as a depth option and starter this season. Patrick Taylor Jr. will lead the 49ers' backfield for the remainder of Sunday's contest.
Jan 5, 2025 4:47 PM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) is off the injury report and ready to roll for a Week 18 matchup with the Cardinals in Arizona. Last week at home versus Detroit, Guerendo took just nine carries for 34 yards but snagged all four targets in the passing game for 65 yards. Arizona's defense represents a favorable opportunity for Guerendo to finish his first NFL campaign on a high note -- they have allowed the 10th-most half-PPR points per game (21.9). Last week, they allowed 14.7 points to Kyren Williams of the Los Angeles Rams. With the 49ers having been eliminated from playoff contention weeks ago and playing their final game of 2024, head coach Kyle Shanahan should give Guerendo his classic heavy lead-back usage while assessing Guerendo's role in 2025. This could be especially true with the 49ers injury issues -- backup Joshua Dobbs is starting for an injured Brock Purdy (right elbow), wideout Deebo Samuel Sr. (rib, wrist) is out, and tight end George Kittle (ankle, hamstring) is questionable. Guerendo is a back-end RB1 in Week 18.
Jan 3, 2025 10:24 PM EST
San Francisco 49ers rookie running back Isaac Guerendo had a useful fantasy day during a 40-34 loss to the Detroit Lions on Monday night. The former high school wide receiver took nine carries for just 34 yards but saved his day through the air by catching all four of his targets for 65 yards. With most fantasy leagues in the books after Monday night, it's fair to say that Guerendo comported himself well in his rookie season by flashing the speed, receiving chops, and scheme fit that caused the 49ers to trade up and select him in the fourth round. Guerendo figures to draw another start while vying for his fifth 10-plus-point half-PPR performance in Week 18's meaningless game in Arizona.
Dec 31, 2024 12:32 AM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) will return from a one-week absence when the team hosts the Detroit Lions on Monday night. Before missing last week's contest against Miami, Guerendo took 16 carries for 57 yards and caught four of four targets for 18 yards versus the Rams. The week before that, the fourth-rounder out of Louisville popped off for 25.8 half-PPR points against Chicago. Detroit has a quality rush defense, having allowed the fourth-fewest points per game to opposing running backs this season. Most recently, they held the Bears to 59 yards and no touchdowns on the ground. It's worth noting that San Francisco is down to their third-string left tackle and could be missing starting right tackle Colton McKivitz (knee), who is questionable. Consider Guerendo a back-end RB2 in Week 17.
Dec 28, 2024 10:37 PM EST
According to Adam Schefter of ESPN, San Francisco 49ers rookie running back Isaac Guerendo (hamstring/foot) is expected to play on Monday evening. The rookie running back was unable to suit up last weekend and has logged two limited practice sessions earlier this week. Fantasy managers should keep a close eye on his status on Saturday's final injury report as a full practice session may help him avoid an injury designation. While sidelined, Patrick Taylor Jr. was given the starting nod and tallied just 24 yards on eight attempts. Guerendo has averaged a solid 19.1 PPR points per game during Weeks 14 and 15 and should be viewed as an RB2 if he is able to suit up on Monday, despite facing a tough Detroit run defense that has allowed the fourth-fewest PPR to the position.
Dec 28, 2024 3:04 PM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) was limited in practice for the second straight day this week on Friday. Guerendo, who did not play in the Week 16 loss to the Miami Dolphins, may need to upgrade to a full practice on Saturday to avoid carrying a questionable designation into Monday night's Week 17 showdown in what will be a rematch of last year's NFC Championship against the Detroit Lions. If the 24-year-old back is feeling good enough to play on Monday, he should return to lead-back duties for San Fran, albeit in a bad matchup. Although they are pretty banged up now, the Lions defense has allowed the fourth-fewest half-PPR points per game to RBs in 15 games in 2024. However, in the last five weeks, they've been in the middle of the pack in that same category. If Guerendo is active in Week 17, he'll be a low-end RB2/high-end RB3/flex in fantasy.
Dec 27, 2024 7:12 PM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) is limited in the team's first practice of the week on Thursday. Guerendo is dealing with two injuries and was unable to play in the Week 16 loss to the Miami Dolphins. It's good news that the 24-year-old is back on the practice field, but he might need to upgrade to a full practice in the next two days to avoid a questionable tag heading into a Monday night game against the Detroit Lions. Guerendo will operate as San Fran's lead back if he's available this week, but the problem is it might not be worth the risk leaving him in starting lineups for championship week in fantasy if he's uncertain to play on Monday night. Additionally, the matchup against Detroit's defense is not a friendly one for fantasy purposes. If Guerendo misses a second straight game, Patrick Taylor Jr. would be in line for a second straight start.
Dec 26, 2024 3:27 PM EST
San Francisco 49ers running back Isaac Guerendo (foot, hamstring) is expected to get back on the practice field on Thursday, according to head coach Kyle Shanahan. The rookie back is dealing with multiple injuries that kept him out of last week's game against the Miami Dolphins. His absence resulted in the 49ers using a committee approach in the backfield with two other backs sidelined as well. The hope is that Guerendo will be able to return for the Week 17 matchup against the Detroit Lions. He could be a low-end RB2 if he's healthy in time for that contest.
Dec 23, 2024 9:33 PM EST
According to Matt Maiocco of NBC Bay Area, San Francisco 49ers running back Isaac Guerendo (hamstring) has been ruled out for Sunday's match against the Miami Dolphins. Guerendo was unable to participate in any team practices this week. He entered his Week 14 game with a foot injury and then left it with a hamstring concern. Fantasy managers should closely monitor his status next week as he may be in danger of missing more time. As a result, fantasy managers should expect Patrick Taylor Jr. to lead a depleted San Francisco backfield on Sunday. Throughout the season, he has tallied 50 yards on 14 attempts and brought in one of his two targets for 12 yards. Taylor should be viewed as a high-floor flex option this weekend facing a Miami rushing defense that has allowed the 12th-most PPR points to opposing RBs this season.
Dec 20, 2024 4:37 PM EST
San Francisco 49ers rookie running back Isaac Guerendo (hamstring) is dealing with a hamstring injury and is unlikely to play in Week 16 versus the hosting Miami Dolphins at Hard Rock Stadium on Sunday, according to a source. The Niners' backfield has just been decimated by injuries this year, with Christian McCaffrey (knee), Jordan Mason (ankle) and Elijah Mitchell (hamstring) already out for the season. Guerendo handled himself nicely as the starting RB for San Fran the last two games, carrying the ball 31 times for 135 yards (4.35 yards per carry) and two touchdowns while catching all six of his targets for another 68 yards. Fantasy managers won't have him available for semifinal matchups this week, though, with Patrick Taylor Jr. likely sharing rushing attempts with receiver Deebo Samuel Sr. against Miami. Israel Abanikanda will also likely be available as a backup. Taylor will be an RB3/flex, at best, in fantasy.
Dec 19, 2024 12:25 PM EST
San Francisco 49ers rookie running back Isaac Guerendo (hamstring) is not taking part in Wednesday's practice due to a hamstring injury. The rookie out of Louisville did not practice on Wednesday or Thursday last week due to a foot injury, so it appears he picked up a new ailment in last Thursday's loss to the Los Angeles Rams. Guerendo handled 100% of the team's running back touches (20) last week, but another injury could result in Patrick Taylor Jr. entering the fantasy football radar. Fantasy managers counting on Guerendo should pick up Taylor as an insurance policy for the fantasy football playoffs. The Dolphins present a neutral matchup for fantasy running backs, so whoever gets the start could have RB1 upside in Kyle Shanahan's offense.
Dec 18, 2024 3:00 PM EST
San Francisco 49ers rookie running back Isaac Guerendo was inefficient during a 12-6 loss to the Los Angeles Rams in Santa Clara on Thursday night. There was some question coming into the game about whether Guerendo -- who spent the week questionable with a foot injury -- could fulfill head coach Kyle Shanahan's typical bell cow usage. Guerendo answered those questions emphatically by taking 16 of San Francisco's 18 carries, but he struggled to make them count, finishing with 57 yards and no touchdowns. He also caught all four of his targets for 18 yards, keeping his night in line with fantasy projections in PPR leagues. Assuming no aggravation of his injury, the fourth-rounder will be in play for lineups in Week 16 versus the Dolphins in Miami, who have been a mildly favorable matchup for running backs this season.
Dec 13, 2024 12:10 AM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot) is officially active for Thursday night's divisional clash in Week 15 versus the visiting Los Angeles Rams. Guerendo suffered a mild foot sprain in the first start of his career in the Week 14 blowout win over the Chicago Bears but will be active on a short week. Before hurting his foot on Sunday, Guerendo had 15 carries for 78 yards (5.2 yards per tote) and two rushing touchdowns, also catching both of his targets for 50 yards through the air. The 24-year-old sure looked good in the lead-back role for San Fran with both Christian McCaffrey (knee) and Jordan Mason (ankle) out. Guerendo will likely be the Niners' lead back the rest of the season, although he'll certainly come with more risk on Thursday night and could share more of the backfield work with Patrick Taylor Jr. Consider Guerendo a volume-based RB3/flex in Week 15.
Dec 12, 2024 7:05 PM EST
San Francisco 49ers running back Isaac Guerendo (foot) "plans to play" in Thursday night's game against the Los Angeles Rams. According to Adam Schefter of ESPN, despite being listed as questionable, Guerendo "feels good" and "plans to play" on Thursday night. The 24-year-old suffered a foot sprain in last Sunday's win over the Chicago Bears. He was a limited participant in Wednesday's walkthrough and has a chance of playing on Thursday. Guerendo rushed for 78 yards and two touchdowns on 15 carries while catching two passes for 50 yards in the Week 14 win over the Bears. With the short week and Christian McCaffrey (knee) and Jordan Mason (ankle) on injured reserve, the 49ers might play it safe with Guerendo and rest him. If Guerendo can't suit up, Patrick Taylor Jr. is expected to handle most of the carries, while Israel Abanikanda and Ke'Shawn Vaughn will back him up. Fantasy managers will have to check back an hour before the 8:15 p.m. (ET) kickoff to ensure Guerendo is active before setting their lineups for the first week of the fantasy playoffs.
Dec 12, 2024 8:35 AM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot) is listed as questionable for Thursday's night game against the Los Angeles Rams, according to Josh Dubow of the Associated Press. Guerendo sustained this injury last weekend during their victory over the Chicago Bears. Before the injury the fourth-round rookie tallied 78 yards and two scores on 15 attempts. With both Christian McCaffrey (knee) and Jordan Mason (ankle) on the injured reserve, Guerendo was slated to operate as the lead running back for the remainder of the season. However, dealing with his own injury, Patrick Taylor Jr. may be given the starting nod on Thursday. Taylor ran for 25 yards and a touchdown after Guerendo left and could be a viable RB2 in all formats if he is given the starting nod.
Dec 11, 2024 4:18 PM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot) had his jersey on at the team' walkthrough practice on Tuesday and was walking around without a limp, but he didn't take part and was listed as a non-participant for the second straight day this week. The 49ers will see how much progress Guerendo makes over the next two days. If Guerendo is unable to play on Thursday against the division-rival Los Angeles Rams, the 49ers' RB pecking order will likely be Patrick Taylor Jr., then Ke'Shawn Vaughn and then Israel Abanikanda. Christian McCaffrey (knee) is done for the year, while Jordan Mason (ankle) could also miss the rest of the year with a high-ankle sprain. The 24-year-old Guerendo delivered immediately for fantasy managers in the Week 14 win over the Chicago Bears, going for 128 scrimmage yards and two scores, but right now, he's up in the air to play on a short turnaround in Week 15.
Dec 10, 2024 8:28 PM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot) has been diagnosed with a foot sprain and is considered day-to-day this week to "see if he's got a shot" to play on Thursday night against the division-rival Los Angeles Rams in Week 15, according to head coach Kyle Shanahan. The 24-year-old rookie said himself he was removed in the second half of Sunday's win over the Chicago Bears as a precaution and that he felt fine, but it wouldn't be a surprise to see him held out on a quick turnaround. In his first start of the year with both Christian McCaffrey (knee) and Jordan Mason (ankle) out, Guerendo looked great for his fantasy managers, racking up 128 scrimmage yards and two touchdowns on 17 touches. Guerendo has become a must-start in fantasy as the 49ers' lead back, but he could be out or limited this Thursday, paving the way for Patrick Taylor Jr. to make a start.
Dec 9, 2024 4:03 PM EST
San Francisco 49ers rookie running back Isaac Guerendo (foot) exited the Week 14 blowout win over the Chicago Bears early on Sunday with a foot injury, but he said the move to remove him from the contest was for precautionary reasons and that he feels great. It's good news, but Guerendo could be dealing with a foot sprain and he'll go for additional testing on Monday. It may not be a very serious injury, but the Niners have a short turnaround in Week 15 with a pivotal divisional matchup this Thursday night against the Los Angeles Rams upcoming. The 24-year-old contributed right away for fantasy managers that picked Guerendo up with Christian McCaffrey (knee) done for the year and Jordan Mason (ankle) expected to land on Injured Reserve, racking up 128 scrimmage yards and two TDs on Sunday. If he cannot get cleared for Thursday night, Patrick Taylor Jr. figures to be San Fran's lead back.
Dec 9, 2024 12:02 PM EST
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