Who Should I Start? James Cook or Omarion Hampton

Sunday, September 28, 9:47 PM

Buffalo Bills running back James Cook posted another huge game in Week 4 in his team's 31-19 victory over the New Orleans Saints. Cook recorded 117 yards and a touchdown on 22 carries and added three catches for 18 yards for good measure as well. The 26-year-old has now logged 401 rushing yards and five touchdowns on 75 carries and 12 receptions for 89 yards through his first four games of 2025. He dominated backfield touches in Week 4, earning 22 out of 24 rush attempts by running backs for Buffalo against New Orleans. As long as he's healthy, Cook is a must-start fantasy running back.

Tuesday, September 30, 12:23 AM

Los Angeles Chargers rookie running back Omarion Hampton impressed in the team's first loss of the season to the New York Giants, 21-18. He rushed 12 times for 128 yards and a touchdown, and caught all five of his targets for 37 yards. His 54-yard touchdown showcased his strength and speed, as he continues to be one of the league leaders in forced missed tackles this season. With Najee Harris (Achilles) out for the year, Hampton played over 90% of the snaps and led in the two-minute offense, solidifying his role as a bell-cow running back. In Week 5, he faces a Washington Commanders' defense that is decent against the run but just allowed Atlanta Falcons' running back Bijan Robinson to dominate them through the air. He's heading toward RB1 status, with top-five weekly potential if he maintains this pace.