Who Should I Start? James Cook or Omarion Hampton

Saturday, December 27, 10:18 AM

Buffalo Bills running back James Cook was dominant in Week 16's win over the Cleveland Browns, totaling 134 scrimmage yards and two touchdowns on just 17 touches. Cook has ascended once again in the 2025 season, jumping from 79.2 scrimmage yards per game in 2024 to 121.3 this season. He currently leads the NFL in rushing yards and ranks RB6 in PPR formats. The Bills host the Philadelphia Eagles in Week 17, who have allowed the eighth-most fantasy points to running backs this season. While star defensive tackle Jalen Carter will be active this week for the Eagles, Cook and the Bills are running the ball with ease, so fantasy managers should expect more dominance from the fourth-year back.

Friday, January 2, 5:00 PM

Los Angeles Chargers rookie running back Omarion Hampton (ankle) has been ruled out for Week 18's regular-season finale against the Denver Broncos, ESPN's Adam Schefter reports. Hampton missed all three days of practice this week and is set to miss the eighth game of his rookie campaign. The 2025 first-round pick spent time on Injured Reserve earlier in the year with a fractured ankle, and it seems that the Chargers are just being cautious with a playoff spot already locked up. Hampton finishes the season with 124 carries for 545 yards and four touchdowns to go with 32 receptions (35 targets) for 192 yards and one touchdown as a receiver. Second-year back Kimani Vidal (neck) was a full participant in practice on Thursday and Friday, so he should be expected to lead the backfield in Week 18 versus the Broncos if he's active. Both Vidal and Hassan Haskins (concussion) are considered questionable to play.