Who Should I Start? James Cook or Trey Benson

Sunday, September 28, 9:47 PM

Buffalo Bills running back James Cook posted another huge game in Week 4 in his team's 31-19 victory over the New Orleans Saints. Cook recorded 117 yards and a touchdown on 22 carries and added three catches for 18 yards for good measure as well. The 26-year-old has now logged 401 rushing yards and five touchdowns on 75 carries and 12 receptions for 89 yards through his first four games of 2025. He dominated backfield touches in Week 4, earning 22 out of 24 rush attempts by running backs for Buffalo against New Orleans. As long as he's healthy, Cook is a must-start fantasy running back.

Wednesday, October 1, 2:19 PM

Arizona Cardinals running back Trey Benson (knee) is expected to miss four-to-six weeks after undergoing arthroscopic surgery on his meniscus, another setback for a backfield already reeling from the season-ending loss of James Conner (foot). Benson had been working into a steady role with 29 carries for 160 yards and 13 receptions for 64 yards through four games, but his absence now opens the door for Emari Demercado to take on feature-back responsibilities. Demercado should be added in all fantasy formats as he projects to see the bulk of opportunities in both the running and passing game, especially with Arizona lacking proven depth behind him. While Benson showed flashes of efficiency early, his return timetable places him on injured reserve and makes him droppable unless you have an IR spot available.