Who Should I Start? Joe Mixon or Isaac Guerendo

Friday, June 20, 12:20 AM

Houston Texans running back Joe Mixon (ankle, foot) is expected to be ready at some point during training camp this summer, according to KPRC 2 Sports' Aaron Wilson. It's a bit ambiguous, but Wilson also goes on to say that it's possible Mixon will be taking part in workouts on the first day of camp in late July. The 28-year-old apparently aggravated ankle and foot injuries that he battled through in 2024, which is why he didn't take part in OTAs this spring. Barring a setback, Mixon should be ready for the start of the regular season, but it's certainly something that fantasy managers should be keeping close tabs on after he was in a protective brace. He finished as the RB15 in half-PPR leagues in his first year in Houston but was noticeably quiet toward the end of the year after battling ankle issues. There are injury concerns with Mixon, but he should at least be a high-end RB2 with plenty of volume if he can stay on the field.

Friday, June 6, 12:54 PM

San Francisco 49ers running back Isaac Guerendo (ankle, knee) has been taking part in voluntary organized team activities this spring after injuring his MCL and spraining his ankle in the Week 18 regular-season finale last year. Guerendo, a fourth-round pick (129th overall) in 2024, should be a full-go for the start of mandatory minicamp on June 10. All-Pro Christian McCaffrey (knee) is also back and ready to roll after missing the majority of the 2024 campaign, so Guerendo will enter the 2025 season as the backup, but Jordan Mason was traded to the Minnesota Vikings and Elijah Mitchell left in free agency. The 24-year-old Guerendo had 5.0 yards per carry on his 84 rushing attempts last year for 420 yards and four touchdowns in 16 games (three starts), adding 15 catches for 152 yards through the air. Consider him a high-upside handcuff behind the injury-prone CMC.