Who Should I Start? Kendre Miller or Isaac Guerendo

Monday, October 20, 1:21 PM

New Orleans Saints running back Kendre Miller (knee) suffered a torn ACL in the Week 7 loss to the Chicago Bears on Sunday and will miss the rest of the year, sources told Jordan Schultz of FOX Sports. It's a tough blow for Miller and for the Saints' backfield depth behind starter Alvin Kamara. The 23-year-old had ascended into the biggest role of his career in his third year in the league as the direct backup to Kamara, carrying the ball 47 times for 193 yards (career-best 4.1 yards per tote) and a touchdown while adding five catches on five targets for 30 yards as a pass-catcher through seven games. Miller has been plagued by the injury bug since entering the NFL as a third-rounder in 2023, as he missed 20 of a possible 34 games in his first two seasons. With Miller now sidelined until next year, rookie Devin Neal becomes the primary handcuff option for Kamara's fantasy managers.

Tuesday, October 21, 9:16 PM

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.