Who Should I Start? Matthew Stafford or Bo Nix

Saturday, October 17, 6:32 AM

Los Angeles Rams quarterback Matthew Stafford has ranked near the top of the fantasy football leaderboard in three of his last four games, and he should continue to produce at a very high level in Week 6 against the Arizona Cardinals. Stafford is coming off a 383-yard, three-touchdown performance against the Bills, during which he also completed a career-high 40 passes. He should continue to throw the ball very often in Week 6, given that this game has an implied total of 51.5 points. Furthermore, Arizona has allowed the most points in the NFL this season, with 32.4 points surrendered per game. The Cardinals have also given up the third-most fantasy points to opposing quarterbacks in 2026. The Rams definitely should have a positive game script in this one, but it might not be so extreme that the Rams just run the ball for 60 minutes. We still expect Stafford to have a big day, positioning him as a mid-range QB1 in fantasy football.