San Francisco 49ers running back Christian McCaffrey handled 22 carries and caught eight passes for 139 total scrimmage yards in the Niners' 26-23 win over the Rams in Week 5. He is up to five consecutive top-12 finishes among running backs to start the season and leads the league with 130 touches. San Francisco's offense is leaning heavily on McCaffrey as it navigates a myriad of injuries to its star players. Brock Purdy (toe) and Ricky Pearsall (knee) will be shelved for their second consecutive game in Week 6 and both Mac Jones (knee, oblique) and Jauan Jennings (ankle, ribs) are listed as questionable. McCaffrey should see another big workload on Sunday against the Buccaneers and contend for another RB1 finish.
Oct 11, 2025 5:26 AM EST
San Francisco 49ers running back Christian McCaffrey rushed for 57 yards on 22 carries during Thursday's Week 5 win over the Los Angeles Rams. He also caught eight of his nine targets for 82 receiving yards and a receiving touchdown. The superstar running back handled 30 total touches, continuing to prove that he's the only relevant member of the Niners' backfield for the time being. His efficiency on the ground was a little underwhelming, but that didn't stop him from dominating as a pass catcher, per usual. The 29-year-old has exceeded 22.5 fantasy points (PPR) in every game this season, ranking as the overall RB1 to this point. He should be started with full confidence against the Buccaneers in Week 6.
Oct 3, 2025 12:32 AM EST
San Francisco 49ers running back Christian McCaffrey will be relied on to carry the team's offense in Week 5. This is not unusual, but the load will be even heavier (metaphorically, but likely also literally) on Thursday, with wide receivers Ricky Pearsall (knee) and Jauan Jennings (ankle/ribs) declared out due to injuries. Quarterback Brock Purdy (toe) will also be on the sidelines, and cede starting duties to Mac Jones for the third time in four games. McCaffrey has been a force regardless of who is under center, starting the season with four straight top-10 PPR finishes at running back. He has been especially productive through the air, ranking second in the league in targets (43) and eighth in yardage (305). The rest of San Francisco's offense might be falling apart, but for as long as McCaffrey is healthy, he has RB1 potential and should be locked into starting fantasy lineups.
Oct 2, 2025 1:52 AM EST
San Francisco 49ers running back Christian McCaffrey struggled to be efficient as a rusher in his team's Week 4 loss to the Jacksonville Jaguars, finishing with 17 carries for 49 yards. However, McCaffrey saved his day with his work as a receiver, hauling in six catches for 92 yards and a touchdown on 11 targets. The 29-year-old has now recorded 560 yards from scrimmage and two touchdowns on 100 total touches through four games. McCaffrey has not had much success on the ground (3.3 yards per carry), but it won't matter as long as he keeps seeing such a high volume of targets in the passing game. If McCaffrey's health continues to hold up under this type of per-game workload, he could be the number one player in fantasy this season.
Sep 28, 2025 9:09 PM EST
San Francisco 49ers running back Christian McCaffrey has started the season with three straight RB1 performances, be it standard, half-PPR scoring, or full-PPR scoring. Narrowed down to full-PPR, he has finished in the top five among running backs in each of the first three weeks of 2025. McCaffrey is poised to continue the streak on Sunday when he squares off against the Jacksonville Jaguars. The Jags have been successful at limiting the productivity of opposing backs, but McCaffrey is as matchup-proof as they come. The team's reliance on him will be heightened with wide receivers Jauan Jennings (ankle/shoulder) and Ricky Pearsall (knee) both questionable for the game. Through three weeks, McCaffrey has 52 carries for 176 rushing yards, and his team-leading 25 receptions rank fourth-most in the league. McCaffrey should be locked into starting lineups for Week 4.
Sep 27, 2025 4:34 AM EST
San Francisco 49ers running back Christian McCaffrey continues to be a high-volume workhorse for the Niners early in the 2025 season. In the one-point win over the visiting Arizona Cardinals in Week 3 on Sunday, McCaffrey had 17 rushing attempts for 52 yards and caught 10 of his 15 targets for 88 yards through the air. CMC was unable to find the end zone, but his workhorse role and good health (so far) have been music to his fantasy managers' ears. The Niners have been leaning on the 29-year-old with quarterback Brock Purdy (toe, shoulder), tight end George Kittle (hamstring), and receiver Jauan Jennings (ankle, shoulder) injured. He has exceeded 100 scrimmage yards in all three games so far this year and will have a good chance to make it four in a row in Week 4 against the Jacksonville Jaguars, especially if Purdy can return. CMC still has league-winning dual-threat abilities, but he'll need to stay healthy.
Sep 21, 2025 10:20 PM EST
After back-to-back top-five finishes at his position, San Francisco 49ers running back Christian McCaffrey is set to continue his dominant start to the season on Sunday. In Week 3, the 49ers match up against the Arizona Cardinals, a team that has been kind to McCaffrey in the past. In seven career games against them, McCaffrey has averaged 145 scrimmage yards and has ten total touchdowns. Concerns over McCaffrey's injury history dissuaded some fantasy football managers from drafting him, but the team has not been shy about getting the ball in his hands. McCaffrey had 31 touches in the season opener and leads the team in targets and receptions. A healthy McCaffrey has weekly overall RB1 potential. He should be locked into starting lineups for Week 3.
Sep 20, 2025 4:29 AM EST
San Francisco 49ers running back Christian McCaffrey rushed for 55 yards on 13 carries during Sunday's Week 2 victory over the New Orleans Saints. He also caught six of seven targets for an additional 53 receiving yards and one receiving touchdown. Although the veteran playmaker didn't quite eclipse the 100-yard mark, he made up for it by scoring his first touchdown of the 2025 campaign. He also served as a very valuable and dependable pass-catching option for quarterback Mac Jones amidst the injury to Brock Purdy (shoulder). McCaffrey has wasted no time making a big impact in fantasy football, scoring at least 22.7 points (PPR) in each of his first two games this year. There's minimal competition for the 29-year-old in San Francisco, keeping him in the mid-range RB1 tier ahead of Week 3 versus the Arizona Cardinals.
Sep 14, 2025 8:39 PM EST
San Francisco 49ers running back Christian McCaffrey is not listed on the team's final injury report for Week 2. McCaffrey did not practice on Wednesday with his injury description listed as both calf and resting, but practiced in full on Thursday and Friday. The 29-year-old carried a questionable tag into the season opener but logged 31 touches for 162 scrimmage yards in the 49ers' 17-13 win over the Seahawks. With quarterback Brock Purdy (toe, shoulder) ruled out and tight end George Kittle (hamstring) on injured reserve, the offense can be expected to run through McCaffrey once again when the 49ers face the Saints on Sunday. A weekly favorite for an RB1 finish, he is a must-start for Week 2.
Sep 13, 2025 12:25 AM EST
San Francisco 49ers running back Christian McCaffrey (calf) returned to practice on Thursday after being rested in the first practice of the week on Wednesday. It's unclear if McCaffrey was a full or limited participant, but he should be good to go for Week 2 against the New Orleans Saints as long as he doesn't suffer any sort of setback on Friday. The 29-year-old oft-injured RB popped up on last week's injury report on Thursday but proceeded to play in the Week 1 win over the Seattle Seahawks. CMC had a positive season opener after being the biggest fantasy bust in 2024 due to injuries, as he produced 142 scrimmage yards. He ran for 69 yards on 22 carries and also caught nine of his 10 targets for an additional 73 yards through the air. Quarterback Brock Purdy (toe) is not expected to play in Week 2, but McCaffrey should continue to be a target hog, especially with tight end George Kittle (hamstring) out three to five weeks. He's a must-start in all fantasy formats.
Sep 11, 2025 6:06 PM EST
San Francisco 49ers running back Christian McCaffrey (calf, rest) did not participate in practice on Wednesday. This shouldn't come as a surprise after McCaffrey dealt with a calf issue all throughout last week. It didn't stop him from playing as he rushed 22 times for 69 yards while hauling in nine receptions for an additional 73 yards in the season opener. He opens the practice week on the sideline, but that is probably for rest purposes. The 49ers want to give McCaffrey time to fully heal his calf issue. Fantasy managers should expect McCaffrey to be out there for Week 2. He'll remain an elite RB1 as long as he can stay healthy.
Sep 10, 2025 9:13 PM EST
San Francisco 49ers running back Christian McCaffrey was the central focus of his team's offense in a 17-13 49ers' win over the Seattle Seahawks in Week 1. McCaffrey rushed 22 times for 69 yards and caught nine passes for 73 yards, a comforting sign for fantasy managers who might have been worried that a lingering calf issue would lead to San Francisco limiting his touches early in the season. The 49ers lost two offensive weapons in George Kittle (groin) and Jauan Jennings (shoulder) during the game. If Kittle and Jennings miss time going forward, San Francisco could be forced to lean on McCaffrey just as heavily in the weeks to come. As long as he's on the field, he's a must-start fantasy running back with game-breaking upside.
Sep 7, 2025 9:17 PM EST
San Francisco 49ers running back Christian McCaffrey (calf) is not listed among the team's inactives for Week 1 against the Seattle Seahawks, per David Lombardi of The San Francisco Standard. McCaffrey popped up on the team's injury report earlier this week with a calf injury, but it does not appear that the injury will keep him out of the lineup for the 49ers. McCaffrey battled through multiple injuries in 2024 that caused him to miss most of the season. As long as he's active and on the field, he's a must-start fantasy running back.
Sep 7, 2025 2:46 PM EST
San Francisco 49ers running back Christian McCaffrey (calf) will play in Sunday's season opener against the Seattle Seahawks, according to ESPN's Adam Schefter. McCaffrey had been listed as questionable, and there was genuine concern about his availability after he missed practice on Friday. However, in the end, it appears the star running back will suit up. Fantasy managers should expect him to receive a normal workload, which means he could earn around 20 touches. He remains a very strong mid-range RB1 option thanks to his talent, productivity, and role in an effective Niners offense.
Sep 7, 2025 11:18 AM EST
San Francisco 49ers running back Christian McCaffrey (calf) did not practice on Friday, but he was a "big participant in the walkthrough on Saturday," according to NFL Network's Ian Rapoport. As a result, the star running back is trending toward playing. Fantasy managers are holding their breath and hoping that McCaffrey avoids a repeat of the 2024 season when he was expected to be healthy for Week 1 but then ultimately missed the first nine games. We'll get confirmation on his status around 2:35 p.m. ET when the 49ers post their list of inactive players. If McCaffrey does suit up against the Seahawks, he'll rank as a mid-range RB1 in fantasy football.
Sep 7, 2025 10:07 AM EST
San Francisco 49ers running back Christian McCaffrey is expected to play Sunday against the Seattle Seahawks, according to Ian Rapoport. After sitting out Friday's practice with a calf injury, McCaffrey expressed confidence in his media availability on Friday. Rapoport reported that barring any setbacks, McCaffrey is likely to suit up. The Five-Time Pro Bowl running back missed significant time last season due to a calf strain, making this update a welcome relief for fantasy managers. He faces a Seahawks defense that was middle-of-the-pack against running backs in 2024, but McCaffrey has historically dominated Seattle, averaging 158 yards per game in six career matchups. While the risk of reinjury is always present with McCaffrey, he remains a must-start fantasy option this week given his workload and track record against the Seahawks.
Sep 6, 2025 3:59 PM EST
San Francisco 49ers running back Christian McCaffrey (calf) said he "feels great" despite carrying a questionable tag into Sunday's season opener against the Seattle Seahawks. The star running back was not listed on Wednesday's initial injury report but was downgraded to limited on Thursday. However, on Friday, McCaffrey took a further step back, as he was listed as a non-participant. Fantasy managers should continue to keep a close eye on his status as he could end up being a game-time decision. Last season, the 29-year-old appeared in only four games as he missed time due to Achilles tendinitis in both legs. If McCaffrey were to miss Sunday's game, fantasy managers should expect Brian Robinson Jr. to see the bulk of the carries while Isaac Guerendo moves up to the backup spot.
Sep 5, 2025 5:59 PM EST
San Francisco 49ers running back Christian McCaffrey (calf) is officially listed as questionable for the Week 1 season opener on Sunday against the division-rival Seattle Seahawks due to a calf issue, according to Cam Inman of the Bay Area News Group. After reports that CMC was fully healthy and looking like his MVP self in training camp this summer, the oft-injured RB popped up on Thursday's injury report and was limited in practice. On Friday, the 29-year-old didn't take part in drills with the rest of the team and was seen on a side field rehabbing. He was questionable entering last year's season opener and ended up missing the first eight games with bilateral Achilles tendinitis. It's a different year, but things could be trending toward him sitting out in Week 1 again. We hope you handcuffed Brian Robinson Jr. or Isaac Guerendo if you took the plunge on McCaffrey in drafts this year.
Sep 5, 2025 5:13 PM EST
San Francisco 49ers running back Christian McCaffrey (calf) is working on the side field, according to Matt Maiocco of NBC Sports Bay Area. The star running back was limited during Thursday's practice due to a calf injury after not being listed on the report on Wednesday. Maiocco noted that McCaffrey was not with his teammates as they went through a "pre-practice" routine. Fantasy managers should continue to monitor his status during Friday's practice, as he may carry an injury designation into Sunday's game against the Seahawks if he cannot turn the corner. Last season, McCaffrey missed time due to Achilles tendinitis and would eventually suffer a further setback, which only allowed him to appear in four games. If McCaffrey were to miss Sunday's game, fantasy managers should expect Brian Robinson Jr. to lead the backfield with Isaac Guerendo serving as the No. 2 option.
Sep 5, 2025 3:57 PM EST
San Francisco 49ers running back Christian McCaffrey (calf) recently landed on the injury report this week. McCaffrey seemed fine throughout training camp and the preseason, but now is dealing with a calf injury just days before the season opener. It's worth noting that McCaffrey missed a portion of last season due to a lingering calf issue. According to Tom Pelissero, McCaffrey's absence shouldn't be ringing any alarm bells. Obviously, the 49ers are going to be cautious with McCaffrey if he's feeling any discomfort at all. At the moment, there is no word on the significance of the injury, so it could be very minor. There is no reason to believe that McCaffrey won't be out there for the season opener. If he does miss time, Brian Robinson Jr. and Isaac Guerendo would function as the primary options in the backfield.
Sep 5, 2025 9:23 AM EST
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