San Francisco
49ers
49ers Top Fantasy Players
These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 25, 2026.
| # | Name | Pos | Team | ADP | Bye |
|---|
San Francisco 49ers 2025 Schedule
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers News
Jacob Cowing, Wide Receiver Injuries Lead to Enormous Opportunity for Jacob Cowing
San Francisco 49ers wide receiver Jacob Cowing could take on a significant role in Week 6 and beyond. The 49ers have been one of the NFL's most injured teams this year, and no position has been hit harder in San Francisco than wide receiver. Mike Evans (ribs) and Deebo Samuel Sr. (hamstring) could both sit out Week 6 after missing practice on Friday, and De'Zhaun Stribling (ankle), Christian Kirk (calf), and Demarcus Robinson (ankle) are all on injured reserve. That leaves Jordan Watkins and Cowing as the 49ers' top two healthy receivers. While we haven't seen much of a track record of production from Cowing, the opportunity and volume alone are enough to put him on the WR3/flex radar for as long as Evans and Samuel are hurt. He has played at least 31% of the snaps in each of the last four weeks, and while he did catch his first pass of the season on Sunday, he also lost a fumble. A higher ceiling but similarly low floor await Cowing going forward.
October 16, 2026 9:55 PM EST
Deebo Samuel Sr., Deebo Samuel Sr. has Not Practiced This Week
San Francisco 49ers wide receiver Deebo Samuel Sr. (hamstring) missed a second straight practice on Friday, according to Harrison Rich of The San Francisco Chronicle. Although the 49ers do not plan to place Samuel on Injured Reserve at this time following his hamstring injury on Sunday in the Week 5 win over the division-rival Seattle Seahawks, the 30-year-old veteran is expected to miss several weeks, including Monday night's clash against the Washington Commanders in Week 6. Fantasy managers should not realistically expect him to make a return until their Week 9 game against the Las Vegas Raiders on Nov. 8 after their bye in Week 8. San Francisco is running out of healthy bodies at the receiver position, with veteran Mike Evans (ribs, Achilles) also hobbled and not practicing yet this week. It is possible that Christian Kirk (calf) makes his return from Injured Reserve this weekend to give the team some reinforcements. Samuel was seeing increased usage in 2026 in his return to the Niners given all their injuries and had 16 catches on 20 targets for 206 yards and three touchdowns before his hamstring injury on Sunday.
October 16, 2026 3:00 PM EST
Christian Kirk, Christian Kirk Limited in Friday's Practice
San Francisco 49ers wide receiver Christian Kirk (calf) was listed as a limited participant in Friday's practice, according to The San Francisco Chronicle's Harrison Rich. It was originally believed that it was unlikely that Kirk would have his 21-day practice window opened to return from Injured Reserve this week, but the 29-year-old veteran returned to the field on Thursday and is now an option to make his 2026 season debut on Monday night against the visiting Washington Commanders. The 49ers' receiving corps is among the most banged up in the league, and the team is expected to be without veteran Deebo Samuel Sr. (hamstring) for multiple weeks after he was injured in the Week 5 win over the division-rival Seattle Seahawks. Veteran Mike Evans (ribs, Achilles) continues to play through injuries, but he has not practiced yet this week. Kirk may not return in Week 6, but he is a sneaky waiver-wire pickup in deeper fantasy leagues for those looking for WR depth. When he returns, Kirk has a clear path to WR2 duties in the Bay Area with everyone else literally injured.
October 16, 2026 2:53 PM EST
Mike Evans, Mike Evans Misses Another Practice on Friday
San Francisco 49ers wide receiver Mike Evans (ribs, Achilles) was listed as a non-participant for the second straight day on Friday, according to Harrison Rich of The San Francisco Chronicle. Evans is trending towards being at least questionable for Monday night's contest at home against the Washington Commanders, even if he returns to the practice field for the final session of the week on Saturday. The 33-year-old has been playing through a painful rib injury and is also now dealing with soreness in his Achilles. The 49ers cannot afford to have their best pass-catcher join the list of wideouts on Injured Reserve this year, which is why he has not been practicing much during the week. If Evans returns to practice on Saturday, he could have a good chance of playing in Week 6. The future Hall of Fame receiver will have an even higher target share if he is active on Monday night, with Deebo Samuel Sr. (hamstring) expected to miss time with a hamstring injury he suffered in the Week 5 win over the division-rival Seattle Seahawks. Despite battling nagging injuries in his first year in San Fran, Evans has secured 24 of his 34 targets for 326 yards and three touchdowns and has continued to be a must-start WR2 in fantasy.
October 16, 2026 2:44 PM EST
Deebo Samuel Sr., Deebo Samuel Sr. Not Seen at Practice on Thursday
San Francisco 49ers veteran wide receiver Deebo Samuel Sr. (hamstring) was not seen in the portion of practice open to the media on Thursday, according to Nick Wagoner of ESPN. Samuel suffered a hamstring injury in the Week 5 win over the division-rival Seattle Seahawks that is expected to sideline him for multiple weeks, so it should not come as a big surprise that he is not practicing on Thursday. The good news for the 30-year-old pass-catcher is that head coach Kyle Shanahan said that the team will hold off on placing Samuel on Injured Reserve due to the team's bye in Week 8. Going on IR would have sidelined him for at least four games. With that said, fantasy managers should still be expecting Samuel to miss several games, so he might not be available again for the 49ers until Week 9. San Francisco's receiving corps is the most banged-up unit around the league, with veteran Mike Evans (Achilles, ribs) holding down the fort while battling through multiple injuries. With Samuel set to miss the Week 6 contest on Monday night against the Washington Commanders, veteran Brandin Cooks and Jacob Cowing will be much more involved, as well as tight end George Kittle.
October 15, 2026 1:47 PM EST
