These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 10, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 1.08 | 14 |
| 2 | George Kittle | TE | SF | 4.08 | 14 |
| 3 | Brock Purdy | QB | SF | 6.09 | 14 |
| 4 | Ricky Pearsall | WR | SF | 7.06 | 14 |
| 5 | Jauan Jennings | WR | SF | 7.09 | 14 |
| 6 | San Francisco Defense | DEF | SF | 12.08 | 14 |
| 7 | Brandon Aiyuk | WR | SF | 12.11 | 14 |
Christian McCaffrey's current ADP is 1.08, which is the 8th pick of the 1st round, and 8th selection overall.
George Kittle's current ADP is 4.08, which is the 8th pick of the 4th round, and 43rd selection overall.
Brock Purdy's current ADP is 6.09, which is the 9th pick of the 6th round, and 69th selection overall.
Ricky Pearsall's current ADP is 7.06, which is the 6th pick of the 7th round, and 78th selection overall.
Jauan Jennings's current ADP is 7.09, which is the 9th pick of the 7th round, and 81st selection overall.
San Francisco Defense's current ADP is 12.08, which is the 8th pick of the 12th round, and 139th selection overall.
Brandon Aiyuk's current ADP is 12.11, which is the 11th pick of the 12th round, and 143rd selection overall.
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers wide receiver Ricky Pearsall (knee, ankle) is expected to play against the Chicago Bears on Sunday Night Football in Week 17, according to Adam Schefter of ESPN.com. Pearsall is listed as questionable after practicing in a limited capacity. While star tight end George Kittle (ankle) is unlikely to play, San Francisco will get a major reinforcement in the passing game with Pearsall back from his one-game absence. The second-year receiver had six catches for 96 yards in his last healthy game against the Tennessee Titans, and he'll look to build on that performance this week against the Bears, who have allowed the third-most receiving yards and fifth-most fantasy points to opposing wide receivers in 2025. He ranks as a low-end WR3/flex in deeper leagues.
December 28, 2025 9:18 AM EST
San Francisco 49ers tight end George Kittle (ankle) is "highly unlikely" to play against the Chicago Bears on Sunday Night Football in Week 17, according to Adam Schefter of ESPN.com. Kittle had been listed as questionable, and while he was expected to be a game-time decision, it seemed like he was trending in the wrong direction after missing all three practices this past week. He has been the overall TE2 since Week 8, so his absence will be felt among fantasy managers and the 49ers. As most leagues host their fantasy championships this week, managers should look for replacement options ahead of time. There are plenty of waiver-wire or bench options who play in the afternoon windows of games. Managers who want to wait until Kittle is ruled out tonight could pivot to Jake Tonges (Sunday night) or Colby Parkinson (Monday night).
December 28, 2025 9:13 AM EST
San Francisco 49ers tight end George Kittle (ankle) plans to test out his ankle pre-game ahead of the Week 17 matchup against the Chicago Bears. Kittle hasn't practiced all week due to an ankle injury, but is shaping up as a game-time decision. Fantasy managers will need to make a big decision, as this game doesn't start until 8:20 est. There's a good chance that Kittle's final status won't be known until about an hour before kickoff. If available, Jake Tonges could be worth stashing for fantasy managers waiting on Kittle's final status. Tonges should have an expanded role if Kittle is unable to go.
December 28, 2025 8:18 AM EST
San Francisco 49ers tight end Brayden Willis has been elevated from the practice squad ahead of the Week 17 matchup against the Chicago Bears. The elevation of Willis is not a good sign for fellow tight end George Kittle (ankle), who is questionable for this contest. The fact that Willis was brought up means Kittle is most likely going to miss this weekend's game. If Kittle sits, Jake Tonges figures to operate as the primary tight end in this offense. Tonges posted some decent performances earlier in the season when Kittle was sidelined. He could offer some streaming appeal to tight-end-needy fantasy managers, assuming Kittle is unable to play.
December 27, 2025 6:41 PM EST
San Francisco 49ers wide receiver Demarcus Robinson scored his first touchdown of the season in Week 16, but was only involved enough to see one other target and finished the game with two catches for 23 yards and the score. Since the 49ers' Week 14 bye, Robinson has slid back behind Kendrick Bourne on the depth chart, but saw a slight uptick in playing time last week with Ricky Pearsall (knee, ankle) sidelined due to injuries. Pearsall is questionable for Week 17, as is tight end George Kittle (ankle). Even if both players were to be declared inactive, Robinson would be a long shot to provide fantasy value. In 12 games with the 49ers, Robinson has averaged 2.3 targets per game and owns a 17-222-1 line despite the many injuries to key pass-catchers throughout the season. Robinson is too low of a priority in the 49ers' pecking order to warrant use in the final weekend of fantasy football.
Demarcus Robinson player page.
December 27, 2025 5:31 AM EST
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