These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 10, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 1.08 | 14 |
| 2 | George Kittle | TE | SF | 4.08 | 14 |
| 3 | Brock Purdy | QB | SF | 6.09 | 14 |
| 4 | Ricky Pearsall | WR | SF | 7.06 | 14 |
| 5 | Jauan Jennings | WR | SF | 7.09 | 14 |
| 6 | San Francisco Defense | DEF | SF | 12.08 | 14 |
| 7 | Brandon Aiyuk | WR | SF | 12.11 | 14 |
Christian McCaffrey's current ADP is 1.08, which is the 8th pick of the 1st round, and 8th selection overall.
George Kittle's current ADP is 4.08, which is the 8th pick of the 4th round, and 43rd selection overall.
Brock Purdy's current ADP is 6.09, which is the 9th pick of the 6th round, and 69th selection overall.
Ricky Pearsall's current ADP is 7.06, which is the 6th pick of the 7th round, and 78th selection overall.
Jauan Jennings's current ADP is 7.09, which is the 9th pick of the 7th round, and 81st selection overall.
San Francisco Defense's current ADP is 12.08, which is the 8th pick of the 12th round, and 139th selection overall.
Brandon Aiyuk's current ADP is 12.11, which is the 11th pick of the 12th round, and 143rd selection overall.
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers tight end Jake Tonges had a big game in Week 17, recording seven catches for 60 yards and a touchdown on nine targets. Tonges benefited from the absence of star 49ers tight end George Kittle (ankle), who was sidelined by an ankle injury. Across the six games Kittle has missed this season, Tonges has racked up 29 catches for 269 yards and three touchdowns on 40 targets. However, recent reporting indicates that Kittle is trending towards returning for the 49ers' Week 18 matchup against the Seattle Seahawks. Tonges has been far less productive across the 10 games where Kittle has been active in 2025, hauling in five receptions for 24 yards and two scores on just six targets. If Kittle is indeed active for Week 18, Tonges should be avoided by fantasy managers.
January 2, 2026 10:41 AM EST
San Francisco 49ers running back Christian McCaffrey (back) was removed from the Week 18 injury report on Thursday and will play on Saturday night against the division-rival Seattle Seahawks, according to Jennifer Lee Chan of NBC Sports Bay Area. McCaffrey has dealt with a bit of back stiffness in the final month of the regular season, but it hasn't been a serious issue, and he'll be fine this weekend as the Niners look to secure the No. 1 seed, a first-round bye, and home-field advantage throughout the postseason. The 29-year-old is coming off a second straight 100-yard rushing game in the Week 17 win over the Chicago Bears on Sunday night, in which he had 23 carries for a season-high 140 yards and one touchdown on the ground. CMC added 41 receiving yards on four catches. He remains the do-it-all focal point of San Fran's offense and is a must-start, high-end RB1 in all fantasy leagues in Week 18.
Christian McCaffrey player page.
January 1, 2026 6:31 PM EST
San Francisco 49ers wide receiver Ricky Pearsall (knee, ankle) is listed as questionable on the final injury report for the Week 18 regular-season finale on Saturday night against the division-rival Seattle Seahawks, according to NBC Sports Bay Area's Jennifer Lee Chan. Pearsall missed yet another game in Week 16 due to knee and ankle injuries, but he returned in the Week 17 win over the Chicago Bears and looked great, securing five of his eight targets for 85 yards. The 25-year-old also played 81% of the offensive snaps. Pearsall didn't look to aggravate either of his injuries on Sunday night, so he should be on the right side of questionable to play against the Seahawks this weekend in a game that will decide the No. 1 seed in the NFC playoff picture. It's not an ideal matchup for fantasy, but if Pearsall is active, he'll be in play as a WR3/flex.
January 1, 2026 6:20 PM EST
San Francisco 49ers tight end George Kittle (ankle) is listed as questionable for Saturday night's game against the division-rival Seattle Seahawks in Week 18, according to Jennifer Lee Chan of NBC Sports Bay Area. Kittle missed the Week 17 win over the Chicago Bears with a mid-to-low ankle sprain, but he's feeling better and said this week that he "absolutely" plans to play on Saturday as the Niners seek the No. 1 overall seed in the NFC and a bye in the first round of the playoffs. Fantasy managers will want to check back on the 32-year-old's status on Saturday, but if he's active, as expected, he needs to be locked into all starting lineups. Kittle has found the end zone seven times in 10 games played in 20225, and in the first meeting against the Seahawks on Sept. 7, he had four catches for 25 yards and his first touchdown of the year.
January 1, 2026 6:13 PM EST
San Francisco 49ers tight end George Kittle (ankle) said he "absolutely" expects to play on Saturday against the division-rival Seattle Seahawks in Week 18, according to Nick Wagoner of ESPN. "Fabulous. Great position for Saturday night to punch a one seed. So just with that, I'm doing fantastic," Kittle said when asked how he feels this week. The 32-year-old sat out of the Week 17 win over the Chicago Bears with an ankle injury, but he has been limited in two practices this week and fully intends to play this weekend in a game that will decide the No. 1 seed in the NFC for the postseason. Backup TE Jake Tonges had a career game in the win over Chicago on Sunday night, but he'll revert to a bench role with Kittle expected to play on Saturday. Despite the tough matchup, fantasy managers will want to get Kittle back in their lineups in Week 18.
January 1, 2026 12:17 PM EST
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