These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 10, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 1.08 | 14 |
| 2 | George Kittle | TE | SF | 4.08 | 14 |
| 3 | Brock Purdy | QB | SF | 6.09 | 14 |
| 4 | Ricky Pearsall | WR | SF | 7.06 | 14 |
| 5 | Jauan Jennings | WR | SF | 7.09 | 14 |
| 6 | San Francisco Defense | DEF | SF | 12.08 | 14 |
| 7 | Brandon Aiyuk | WR | SF | 12.11 | 14 |
Christian McCaffrey's current ADP is 1.08, which is the 8th pick of the 1st round, and 8th selection overall.
George Kittle's current ADP is 4.08, which is the 8th pick of the 4th round, and 43rd selection overall.
Brock Purdy's current ADP is 6.09, which is the 9th pick of the 6th round, and 69th selection overall.
Ricky Pearsall's current ADP is 7.06, which is the 6th pick of the 7th round, and 78th selection overall.
Jauan Jennings's current ADP is 7.09, which is the 9th pick of the 7th round, and 81st selection overall.
San Francisco Defense's current ADP is 12.08, which is the 8th pick of the 12th round, and 139th selection overall.
Brandon Aiyuk's current ADP is 12.11, which is the 11th pick of the 12th round, and 143rd selection overall.
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers wide receiver Ricky Pearsall (knee, ankle) is officially active for Sunday Night Football against the Chicago Bears in Week 17. He had been listed as questionable but was trending in the right direction ahead of kickoff. Having Pearsall available is key for the 49ers, who will be without George Kittle (ankle) on Sunday night. While Kittle is irreplaceable, Pearsall's return from a one-game absence fills a significant void in the passing game. He should handle a heavy dose of targets alongside Jauan Jennings and Jake Tonges. As it stands, Pearsall ranks as a mid-range WR3/flex against a Bears defense allowing the fifth-most fantasy points to wide receivers in 2025.
December 28, 2025 7:09 PM EST
San Francisco 49ers tight end George Kittle (ankle) is officially inactive for Sunday's Week 17 contest against the Chicago Bears. He had been listed as questionable, but the odds were stacked against him after he missed all three practices this past week. The 49ers left the door open for him to play, but after Kittle tested his ankle during pre-game warmups, the team decided to hold him out. It's a crushing blow for managers who were hoping to have the star tight end available as the fantasy playoffs continue. Instead, Jake Tonges will operate as the 49ers' top tight end. He's a viable replacement on Sunday Night Football, but his ceiling and floor are both lower than Kittle's. Tonges will rank as a fringe top-12 fantasy tight end in his pass-catching role behind wide receivers Jauan Jennings and Ricky Pearsall.
December 28, 2025 7:04 PM EST
San Francisco 49ers wide receiver Ricky Pearsall (knee, ankle) is expected to play against the Chicago Bears on Sunday Night Football in Week 17, according to Adam Schefter of ESPN.com. Pearsall is listed as questionable after practicing in a limited capacity. While star tight end George Kittle (ankle) is unlikely to play, San Francisco will get a major reinforcement in the passing game with Pearsall back from his one-game absence. The second-year receiver had six catches for 96 yards in his last healthy game against the Tennessee Titans, and he'll look to build on that performance this week against the Bears, who have allowed the third-most receiving yards and fifth-most fantasy points to opposing wide receivers in 2025. He ranks as a low-end WR3/flex in deeper leagues.
December 28, 2025 9:18 AM EST
San Francisco 49ers tight end George Kittle (ankle) is "highly unlikely" to play against the Chicago Bears on Sunday Night Football in Week 17, according to Adam Schefter of ESPN.com. Kittle had been listed as questionable, and while he was expected to be a game-time decision, it seemed like he was trending in the wrong direction after missing all three practices this past week. He has been the overall TE2 since Week 8, so his absence will be felt among fantasy managers and the 49ers. As most leagues host their fantasy championships this week, managers should look for replacement options ahead of time. There are plenty of waiver-wire or bench options who play in the afternoon windows of games. Managers who want to wait until Kittle is ruled out tonight could pivot to Jake Tonges (Sunday night) or Colby Parkinson (Monday night).
December 28, 2025 9:13 AM EST
San Francisco 49ers tight end George Kittle (ankle) plans to test out his ankle pre-game ahead of the Week 17 matchup against the Chicago Bears. Kittle hasn't practiced all week due to an ankle injury, but is shaping up as a game-time decision. Fantasy managers will need to make a big decision, as this game doesn't start until 8:20 est. There's a good chance that Kittle's final status won't be known until about an hour before kickoff. If available, Jake Tonges could be worth stashing for fantasy managers waiting on Kittle's final status. Tonges should have an expanded role if Kittle is unable to go.
December 28, 2025 8:18 AM EST
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