These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 10, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 1.08 | 14 |
| 2 | George Kittle | TE | SF | 4.08 | 14 |
| 3 | Brock Purdy | QB | SF | 6.09 | 14 |
| 4 | Ricky Pearsall | WR | SF | 7.06 | 14 |
| 5 | Jauan Jennings | WR | SF | 7.09 | 14 |
| 6 | San Francisco Defense | DEF | SF | 12.08 | 14 |
| 7 | Brandon Aiyuk | WR | SF | 12.11 | 14 |
Christian McCaffrey's current ADP is 1.08, which is the 8th pick of the 1st round, and 8th selection overall.
George Kittle's current ADP is 4.08, which is the 8th pick of the 4th round, and 43rd selection overall.
Brock Purdy's current ADP is 6.09, which is the 9th pick of the 6th round, and 69th selection overall.
Ricky Pearsall's current ADP is 7.06, which is the 6th pick of the 7th round, and 78th selection overall.
Jauan Jennings's current ADP is 7.09, which is the 9th pick of the 7th round, and 81st selection overall.
San Francisco Defense's current ADP is 12.08, which is the 8th pick of the 12th round, and 139th selection overall.
Brandon Aiyuk's current ADP is 12.11, which is the 11th pick of the 12th round, and 143rd selection overall.
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers general manager John Lynch said on Tuesday at the NFL scouting combine that "nothing will happen until the new league year" when discussing parting ways with wide receiver Brandon Aiyuk (knee), according to Matt Barrows of The Athletic. We already know that Aiyuk won't be playing for the Niners in 2026, but he won't be officially released until the start of the new league year next month. The 27-year-old former first-rounder signed a four-year, $120 million contract with the team in August of 2024 and then played in only seven games that year, catching 25 of 47 targets for 374 yards and no touchdowns. Aiyuk didn't play at all in 2025 due to his knee injury and wasn't going to return to the Bay Area after the team voided guarantees in his contract. He'll certainly attract attention on the open market, but fantasy managers will be wary after all the missed time.
February 25, 2026 5:14 AM EST
San Francisco 49ers general manager John Lynch reiterated the team's desire to keep backup quarterback Mac Jones at the NFL scouting combine on Tuesday, according to Nick Wagoner of ESPN. "He's really good for us, and we value that. And so somebody would have to come with something fairly strong for us to consider (trading him). And then I don't know what we do. Obviously, there's always something that would make you (do it), but I think we're a better team with him on it and we just like having him around," Lynch said. The 27-year-old signed a two-year, $8.41 million deal with San Fran in March of last year and ended up playing in 11 games (eight starts) with Brock Purdy missing a good chunk of the season with a turf-toe injury. Jones played well, too, throwing for 2,151 yards, 13 touchdowns, and six picks while going 5-3. QB-needy teams will come calling, but it sounds like the Niners will need to be blown away by a trade offer to even consider dealing him.
February 25, 2026 5:08 AM EST
San Francisco 49ers tight end George Kittle's (Achilles) optimism for a speedy return in 2026 following a torn Achilles that he suffered in the Wild-Card round win over the Philadelphia Eagles is realistic, according to Dr. Daniel Kaplan, an orthopedic surgeon. Kittle suffered a clean tear that happened high up by his soleus. "They didn't have to drill into my heel," Kittle said. "And where the repair was is where there's more blood flow. And so, it takes some time off the recovery time." Barring a setback during his rehab, it's possible that Kittle could return to the field sometime around September. "It's reasonable to think Week 5 or so would be on the long end of a return," according to ESPN's Nick Wagoner. Kittle and the Niners are hopeful that when he's back, he'll be able to "return to somewhere close to his usual level of production." The 32-year-old will obviously be pretty risky in fantasy in 2026, but he'll be worth stashing everywhere. If Jake Tongues returns as a restricted free agent, he'll be a low-end TE1 sleeper in the first part of the year until Kittle returns.
February 23, 2026 8:24 AM EST
Across 16 games in 2025, San Francisco 49ers wide receiver Kendrick Bourne recorded 37 receptions for 551 yards on 53 targets. A significant chunk of Bourne's production came in a two-game stretch in Weeks 5 and 6, when he hauled in 15 receptions for 284 yards on 20 targets. As the 49ers' pass-catching corps got healthier in the later part of the season, Bourne's role faded out of fantasy relevance. Bourne is now set to hit free agency ahead of 2026, which will be his age-31 season. Fellow 49ers wideout Jauan Jennings is also a free agent, and star San Francisco tight end George Kittle (Achilles) could miss a chunk of 2026 with a torn Achilles tendon. As a result, a return to San Francisco could mean Bourne has a role in the team's passing game, especially early in the year. However, the veteran wideout's best days appear to be behind him, and he may not play a fantasy-relevant role in 2026 and beyond.
February 21, 2026 10:14 AM EST
San Francisco 49ers running back Isaac Guerendo has emerged as a potential drop candidate as dynasty managers prepare for the offseason roster crunch. Between clearing taxi squad spots, adding players, and navigating rookie drafts, dynasty managers may need to make decisions about which rostered players to cut. Guerendo is a prime candidate after an underwhelming second season with the 49ers in 2025. He appeared in 14 games but played exclusively on special teams, never logging an offensive snap. He was buried on the depth chart behind Christian McCaffrey, Brian Robinson Jr., Jordan James, and even fullback Kyle Juszczyk. It was a surprising, harsh development for the Louisville product after he finished as the overall RB48 in PPR leagues with 572 scrimmage yards and five touchdowns in 2024. Evidently, the 49ers don't see Guerendo in their long-term plans, and it's hard to imagine he'll climb the depth chart in 2026, even with Robinson expected to hit free agency. Managers in most dynasty leagues should feel comfortable dropping the 25-year-old.
February 18, 2026 10:02 AM EST
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