These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 10, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 1.08 | 14 |
| 2 | George Kittle | TE | SF | 4.08 | 14 |
| 3 | Brock Purdy | QB | SF | 6.09 | 14 |
| 4 | Ricky Pearsall | WR | SF | 7.06 | 14 |
| 5 | Jauan Jennings | WR | SF | 7.09 | 14 |
| 6 | San Francisco Defense | DEF | SF | 12.08 | 14 |
| 7 | Brandon Aiyuk | WR | SF | 12.11 | 14 |
Christian McCaffrey's current ADP is 1.08, which is the 8th pick of the 1st round, and 8th selection overall.
George Kittle's current ADP is 4.08, which is the 8th pick of the 4th round, and 43rd selection overall.
Brock Purdy's current ADP is 6.09, which is the 9th pick of the 6th round, and 69th selection overall.
Ricky Pearsall's current ADP is 7.06, which is the 6th pick of the 7th round, and 78th selection overall.
Jauan Jennings's current ADP is 7.09, which is the 9th pick of the 7th round, and 81st selection overall.
San Francisco Defense's current ADP is 12.08, which is the 8th pick of the 12th round, and 139th selection overall.
Brandon Aiyuk's current ADP is 12.11, which is the 11th pick of the 12th round, and 143rd selection overall.
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers head coach Kyle Shanahan said that wide receiver Brandon Aiyuk (knee) has been "extremely distant" from the team since suffering a season-ending knee injury in Week 7 of the 2024 season, per Matt Barrows of The Athletic. The 27-year-old has not played a game since that point. The 49ers voided guarantees in his contract for 2026 and placed him on the reserve/left squad list on Saturday, officially ending his 2025 season. All signs seem to indicate that Aiyuk and the 49ers are likely to go their separate ways this offseason. In his last fully healthy season in 2023, Aiyuk recorded 75 receptions for 1,342 yards and seven touchdowns on 105 targets. He has a chance to get back to his superstar heights if he can get fully healthy and find the right team. However, his health and the way his current situation in San Francisco has unfolded may bring about question marks for dynasty league fantasy managers.
December 18, 2025 4:18 PM EST
San Francisco 49ers wide receiver Ricky Pearsall (knee) won't practice on Thursday, but head coach Kyle Shanahan said he's feeling "much better" and that he still has a chance to play on Monday night against the Indianapolis Colts, per ESPN's Nick Wagoner. Pearsall aggravated the PCL injury that caused him to miss six games earlier this season and also sprained his ankle during the Week 15 win over the Titans. The 25-year-old will have an extra day to recover this week, but it still seems unlikely that he'll be able to suit up on Monday night. The second-year wideout produced his third game this season with 95 or more yards against the Titans, finishing with six catches for 96 yards on seven targets. If Pearsall ends up being ruled out, Jauan Jennings would be in line for a larger role, with Kendrick Bourne also becoming a viable flex option in deeper leagues.
December 18, 2025 2:56 PM EST
San Francisco 49ers wide receiver Jauan Jennings has had a solid season and had his first two-touchdown game in the Week 15 win over the Tennessee Titans, hauling in three of five targets for 37 yards. It was Jennings' fourth multi-touchdown game of his career, and first since Week 14 of last season. The 28-year-old has now scored in three straight games and five of the last six, ranking as the WR16 in PPR points in that time. Jennings is third on the 49ers in target share (18.2%) this season, behind star running back Christian McCaffrey (21.3%) and tight end George Kittle (19.7%), after leading the team in that area last season (22.7%). He's been running hot on touchdowns in recent weeks, and projects as a solid WR2 for the Week 16 Monday night matchup against the Indianapolis Colts.
December 18, 2025 12:20 AM EST
San Francisco 49ers wide receiver Jauan Jennings scored two touchdowns in Sunday's 37-24 win over the Titans. Jennings' day was propped up by the scores as he finished with just three catches for 37 receiving yards on five targets. This fits the mold of a trend that has been in the works for the last several weeks. Jennings is now up to six touchdowns in the 49ers' last six games, but in that span, he has averaged 47.2 yards and 4.3 receptions per game, making his fantasy production extremely reliant on touchdowns. Jennings may be in for a more balanced game in Week 16, when the 49ers face the Colts. Indianapolis has given up the most receptions and second-most receiving yards to opposing wide receivers in 2025. He projects as a WR2 candidate for the semi-final round of the fantasy football playoffs.
December 16, 2025 6:42 PM EST
San Francisco 49ers tight end George Kittle led the team in receptions and targets in the team's 37-24 win over the Titans on Sunday. Kittle caught eight of the nine balls thrown his way for a season-high 88 yards and a touchdown, his sixth of the year. Kittle missed five games with a hamstring injury earlier this season and was blanked in his return in Week 7, but since then, he has been a welcome presence on fantasy football rosters. Since Week 8, Kittle has averaged 5.9 receptions, 6.9 targets, and 65.6 yards per game and ranks third among tight ends in receptions and receiving yards. Kittle will again be in the TE1 conversation in Week 16, when the 49ers square off against the Colts on Monday Night Football.
December 16, 2025 6:33 PM EST
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