These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of November 26, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
NFL Network's Tom Pelissero reports that the NFL will review San Francisco 49ers wide receiver Jauan Jennings' actions on Monday night against the Carolina Panthers for a possible fine, but he won't be suspended. Panthers safety Tre'Von Moehrig took a cheap shot to a sensitive area for Jennings late in Monday night's game, and Jennings had to be held back following the conclusion of the contest. The 28-year-old caught five of his seven targets for 41 yards and his fourth touchdown of the season in the 20-9 victory. Three of Jennings' four scores on the year have come in the last four games, and he has a higher fantasy ceiling with quarterback Brock Purdy recovered from a turf-toe injury that caused him to miss most of the season. Going into a tough Week 13 matchup against the Cleveland Browns, Jennings should be viewed as a touchdown-dependent WR3/flex option.
November 25, 2025 3:57 PM EST
San Francisco 49ers quarterback Brock Purdy (toe) went 23-for-32 for 193 yards, one touchdown, and three interceptions in Monday's 20-9 win over the Carolina Panthers. He also had 16 rushing yards on six carries. Purdy struggled to connect with his receivers on intermediate and deep routes, completing just one of his eight attempts of 10 yards or more. All three of his interceptions came on shots 20 yards downfield or longer. In postgame comments, Purdy insisted his picks had nothing to do with the turf toe injury that has cost him eight games this season. The 49ers will travel to Cleveland in Week 13 to face the Browns, whose defense has allowed the third-fewest passing yards and owns the highest sack rate in the league. Purdy projects as a QB2 against that stout defense in what will be a cold-weather game.
November 25, 2025 10:47 AM EST
San Francisco 49ers tight end George Kittle totaled six receptions for 78 yards on 10 targets in a Monday night win over the Carolina Panthers. Kittle led the 49ers in both targets and receiving yards in the win. Outside of zero catch performance in his first game returning from his early-season hamstring injury in Week 7 against the Falcons, the superstar tight end has been as advertised as an early-round pick for fantasy managers. In the other five games, including Monday night, he's racked up 29 catches for 304 yards and four touchdowns on 34 targets, good for an average of 16.6 PPR points per game. The 32-year-old will again profile as a top-three tight end option in Week 13 against the Cleveland Browns.
November 25, 2025 12:43 AM EST
San Francisco 49ers wide receiver Jauan Jennings caught five of seven targets for 41 yards and a touchdown in Monday night's win over the Carolina Panthers. His first-quarter touchdown came on an impressive catch and run where he fought through two defenders on his way into the end zone. Jennings continues his strong stretch of production over the last four games, recording 19 receptions for 217 yards and three touchdowns on 27 targets. The recent return of second-year wideout Ricky Pearsall hasn't affected Jennings' production, with Pearsall totaling just three catches for nine yards in the past two games. The 28-year-old Jennings has been a reliable target earner for San Francisco alongside multiple other capable weapons and a heavy dose of touches devoted to Christian McCaffrey. Jennings will rank on the WR2/WR3 border again in Week 13 against the Cleveland Browns.
November 25, 2025 12:29 AM EST
San Francisco 49ers running back Christian McCaffrey handled another massive workload in Monday night's 20-9 win over the Carolina Panthers, recording 24 carries for 89 yards and a touchdown to go with seven catches (seven targets) for 53 yards in the pass game. McCaffrey now has 298 touches on the season after another 31 in Week 12 against his former team, with Jonathan Taylor being the next closest player at 237. The superstar running back also leads the league in receptions with 81. McCaffrey continues to be one of the top options in all of fantasy football as the engine of San Francisco's offense and a security blanket for quarterback Brock Purdy, who struggled throwing downfield in this game with three interceptions in the first half. McCaffrey will rank as an elite RB1 in Week 13 against the Cleveland Browns.
Christian McCaffrey player page.
November 25, 2025 12:14 AM EST
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