These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of November 18, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers kicker Eddy Pineiro (hamstring) is considered week-to-week after suffering a Grade 1 hamstring strain in the Week 11 win over the Arizona Cardinals on Sunday, according to David Lombardi of The San Francisco Standard. With Pineiro hurt, the 49ers will hold kicker tryouts this week. Lombardi mentions that the Niners could reunite with Jake Moody and sign him off the Chicago Bears' practice squad. San Fran doesn't currently have another placekicker on their roster. The 30-year-old Pineiro had been money for the 49ers this year before his injury, making all 22 of his field-goal attempts, including all six from 50-plus yards, and 18 of his 22 extra-point tries in 10 games. The team will have a bit of extra time to find a new kicker going into their Week 12 matchup against the Carolina Panthers next Monday night.
November 17, 2025 3:36 PM EST
The San Francisco 49ers won't open the practice windows for either wide receiver Brandon Aiyuk (knee) or Jacob Cowing (hamstring) this week, according to head coach Kyle Shanahan. Aiyuk, who has been out all year since tearing multiple ligaments in his knee in Week 7 of 2024, remains "week-to-week. Cowing, meanwhile, will not have his practice window opened until after the team's Week 14 bye. Aiyuk will not make his season debut in Week 12 versus the Carolina Panthers, and he's probably unlikely to return in Week 13 against the Cleveland Browns, either. Time is running out for the 27-year-old former first-rounder to make an impact for fantasy managers who have been stashing him all year. The Niners have a good matchup coming out of their bye in Week 15 against the Titans, but even if Aiyuk can play in that game, he'd be a very risky option for those playing in the first week of the fantasy playoffs in most leagues.
November 17, 2025 3:31 PM EST
San Francisco 49ers quarterback Brock Purdy returned to action on Sunday after missing eight of the team's last nine games with a toe injury, and he threw for 200 yards and three touchdowns in a blowout win over the Cardinals. With one game left to be played on Monday night, he is currently the QB4 for the week, after his efficient outing against an above-average Cardinals defense. While Purdy's upcoming schedule features unfavorable passing matchups against the Panthers and Browns before a Week 14 bye, managers who can afford to keep him rostered through that stretch should be handsomely rewarded with fantasy playoff matchups against the Titans, Colts, and Bears. While streaming the quarterback position often means mixing and matching throughout the playoffs to find the best possible matchup, Purdy is one of the few streaming quality quarterbacks that can be trusted from Weeks 15-17, especially as the 49ers offense continues to get healthier.
November 17, 2025 3:01 PM EST
In his first game since Week 4, San Francisco 49ers quarterback Brock Purdy completed 19 of 26 pass attempts for 200 yards, three touchdowns, and zero interceptions in his team's 41-22 win over the Arizona Cardinals. Purdy missed six games due to a toe injury, but he appears to be regaining his health at the perfect time for San Francisco. Across three starts in 2025, Purdy has now thrown for 786 yards, seven touchdowns, and four interceptions. In addition to Purdy, the 49ers also got wide receiver Ricky Pearsall back from a knee injury that has sidelined him from Week 4. The return of both players helped San Francisco put up a season-high 41 points against Arizona. Purdy profiles as a low-end starting quarterback option in single-QB fantasy leagues and a must-start quarterback in two-QB formats heading into a Week 12 matchup against the Carolina Panthers.
November 16, 2025 10:01 PM EST
San Francisco 49ers tight end George Kittle had a vintage game in Week 11, recording six catches for 67 yards and two touchdowns on six targets in his team's 41-22 win over the Arizona Cardinals. Kittle showed off his established chemistry with 49ers quarterback Brock Purdy, who made his first start since Week 4. The 32-year-old Kittle has now hauled in 27 catches for 251 yards and five touchdowns on 30 targets across six games played this season. He's heating up of late, recording 15 receptions for 151 yards and three scores over the last two weeks. Kittle profiles as a must-start tight end heading into a Week 12 matchup against the Carolina Panthers.
November 16, 2025 9:29 PM EST
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