These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of November 25, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers tight end George Kittle totaled six receptions for 78 yards on 10 targets in a Monday night win over the Carolina Panthers. Kittle led the 49ers in both targets and receiving yards in the win. Outside of zero catch performance in his first game returning from his early-season hamstring injury in Week 7 against the Falcons, the superstar tight end has been as advertised as an early-round pick for fantasy managers. In the other five games, including Monday night, he's racked up 29 catches for 304 yards and four touchdowns on 34 targets, good for an average of 16.6 PPR points per game. The 32-year-old will again profile as a top-three tight end option in Week 13 against the Cleveland Browns.
November 25, 2025 12:43 AM EST
San Francisco 49ers wide receiver Jauan Jennings caught five of seven targets for 41 yards and a touchdown in Monday night's win over the Carolina Panthers. His first-quarter touchdown came on an impressive catch and run where he fought through two defenders on his way into the end zone. Jennings continues his strong stretch of production over the last four games, recording 19 receptions for 217 yards and three touchdowns on 27 targets. The recent return of second-year wideout Ricky Pearsall hasn't affected Jennings' production, with Pearsall totaling just three catches for nine yards in the past two games. The 28-year-old Jennings has been a reliable target earner for San Francisco alongside multiple other capable weapons and a heavy dose of touches devoted to Christian McCaffrey. Jennings will rank on the WR2/WR3 border again in Week 13 against the Cleveland Browns.
November 25, 2025 12:29 AM EST
San Francisco 49ers running back Christian McCaffrey handled another massive workload in Monday night's 20-9 win over the Carolina Panthers, recording 24 carries for 89 yards and a touchdown to go with seven catches (seven targets) for 53 yards in the pass game. McCaffrey now has 298 touches on the season after another 31 in Week 12 against his former team, with Jonathan Taylor being the next closest player at 237. The superstar running back also leads the league in receptions with 81. McCaffrey continues to be one of the top options in all of fantasy football as the engine of San Francisco's offense and a security blanket for quarterback Brock Purdy, who struggled throwing downfield in this game with three interceptions in the first half. McCaffrey will rank as an elite RB1 in Week 13 against the Cleveland Browns.
Christian McCaffrey player page.
November 25, 2025 12:14 AM EST
San Francisco 49ers wide receiver Brandon Aiyuk (knee) continues to recover from last year's ACL injury, and NFL Network's Mike Garafolo reports that Aiyuk is "close to being cleared" for a return. The receiver's 21-day practice window hasn't been opened yet, but the 49ers remain hopeful that he'll get back on the field in the near future. San Francisco's receiving corps could use the help as Jauan Jennings and Ricky Pearsall have been underwhelming, combining for 53 catches, 705 yards, and three touchdowns while managing their respective injuries. Aiyuk could become an instant WR2 or WR3 in fantasy football upon his return, but an exact timetable for his activation remains unclear. This isn't the only news story we've seen about Aiyuk this week, though. A few days ago, Dianna Russini and Michael Silver of The Athletic reported that Aiyuk and the Niners were headed for a "stunning split" after the team voided his 2026 guarantees for a failure to meet contractual obligations, creating a clear path to his release next offseason. While Russini and Silver wrote that Aiyuk has likely played his final game for the 49ers, Garafolo's report seems to clarify that he'll have a good chance to get back on the field in 2025 before the team makes a decision on his future during the offseason.
November 23, 2025 11:55 AM EST
San Francisco 49ers kicker Eddy Pineiro (hamstring) has been ruled out ahead of the Week 12 matchup against the Carolina Panthers. This doesn't come as a surprise after Pineiro failed to practice at all this week. His absence will likely result in Matt Gay being elevated from the practice squad. He figures to serve as the kicker for at least one week with Pineiro having a chance to return in Week 13. Gay has spent most of the season with the Washington Commanders, making 13-of-19 field goal attempts. He has struggled this season, so there should be better streaming options out there ahead of Week 12.
November 22, 2025 6:13 PM EST
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