These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of December 2, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers wide receiver Ricky Pearsall was held to two catches for 14 yards on three targets in the team's 26-8 win over the Browns on Sunday. He now has five catches on nine targets for 20 yards since returning from his PCL injury in Week 11. High winds in Cleveland limited the effectiveness of the 49ers' passing attack, as quarterback Brock Purdy completed just 16 of his 29 pass attempts in the game. Jauan Jennings, George Kittle, and Christian McCaffrey accounted for half of the team's targets, leaving Pearsall once again the odd man out. The 49ers get a bye in Week 14, but Pearsall may be worth a stash. In Weeks 15 through 17, Pearsall will see favorable matchups against the Titans, Colts, and Bears, which could lead to a boon in production over the fantasy football playoffs.
December 2, 2025 5:14 PM EST
San Francisco 49ers wide receiver Jauan Jennings caught four of a team-high six targets for 39 yards and a touchdown in the team's 26-8 win over the Browns in Week 13. With Sunday's trip to the end zone, Jennings now has a touchdown reception in four of the 49ers' last five games. The 28-year-old has ranked first or second in team targets in every game going back to Week 7, though that has not equated to fantasy success. Jennings has had 45 receiving yards or fewer during that stretch, his recent spate of touchdowns salvaging otherwise mediocre production. The 49ers are on bye in Week 14, but Jennings will have a chance to step things up against some generous opponents in the fantasy football playoffs. In Weeks 15 through 17, San Francisco faces the Titans, Colts, and Bears, all of which rank in the top ten in points allowed to opposing wide receivers.
December 2, 2025 5:00 PM EST
San Francisco 49ers tight end George Kittle led the team with 67 receiving yards in their 26-8 win over the Cleveland Browns on Sunday. Kittle had five targets and tied for the team high with four catches on a day when quarterback Brock Purdy completed just 16 passes. Almost half of his yardage came on San Francisco's last snap of the first half, when Purdy hit Kittle on a 33-yard bomb that set up a chip-shot field goal for Matt Gay before halftime. Kittle finished outside of top-12 territory for the first time since Week 9, but is working on a four-game streak with at least four catches and 67 receiving yards. The 49ers are on bye in Week 14, but will see favorable matchups in the fantasy football playoffs with games against the Titans, Colts, and Bears.
December 2, 2025 4:36 PM EST
San Francisco 49ers running back Christian McCaffrey handled 20 carries for 53 yards and a touchdown in the team's 26-8 win over the Browns in Week 13. He also caught all four of his targets for 21 receiving yards. Sunday's game was just the third time this season that McCaffrey finished with fewer than 100 scrimmage yards, and his four targets were a season low. Still, the two-time All-Pro finished as a top-12 running back in PPR scoring for the twelfth time in 13 weeks. Fantasy football managers will have to do without McCaffrey's services in Week 14 while the 49ers are on bye. Those lucky enough to have sewn up a spot in the fantasy football playoffs get to look forward to a matchup against the Titans in Week 15.
Christian McCaffrey player page.
December 2, 2025 4:21 PM EST
San Francisco 49ers general manager John Lynch said he is "not sure" but "hopeful" when asked if it's realistic to expect wide receiver Brandon Aiyuk (knee) to take the field in 2025, per David Lombardi of The San Francisco Standard. Aiyuk tore multiple ligaments in his knee in Week 7 of the 2024 season and has yet to play in a game since. Aiyuk was one of the most efficient wide receivers in the NFL in the last full season he played back in 2023, recording 75 catches for 1,342 yards and seven touchdowns on 105 targets. However, it appears as though he may not be healthy until 2026. Aiyuk also may be locked into a contract stand-off with the team, as the 49ers reportedly voided guarantees in his current contract. Between the injury and the contractual issues, fantasy managers should likely proceed as though Aiyuk will not play a fantasy-relevant role in 2025.
December 2, 2025 11:37 AM EST
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