These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 10, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 1.08 | 14 |
| 2 | George Kittle | TE | SF | 4.08 | 14 |
| 3 | Brock Purdy | QB | SF | 6.09 | 14 |
| 4 | Ricky Pearsall | WR | SF | 7.06 | 14 |
| 5 | Jauan Jennings | WR | SF | 7.09 | 14 |
| 6 | San Francisco Defense | DEF | SF | 12.08 | 14 |
| 7 | Brandon Aiyuk | WR | SF | 12.11 | 14 |
Christian McCaffrey's current ADP is 1.08, which is the 8th pick of the 1st round, and 8th selection overall.
George Kittle's current ADP is 4.08, which is the 8th pick of the 4th round, and 43rd selection overall.
Brock Purdy's current ADP is 6.09, which is the 9th pick of the 6th round, and 69th selection overall.
Ricky Pearsall's current ADP is 7.06, which is the 6th pick of the 7th round, and 78th selection overall.
Jauan Jennings's current ADP is 7.09, which is the 9th pick of the 7th round, and 81st selection overall.
San Francisco Defense's current ADP is 12.08, which is the 8th pick of the 12th round, and 139th selection overall.
Brandon Aiyuk's current ADP is 12.11, which is the 11th pick of the 12th round, and 143rd selection overall.
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers wide receiver Ricky Pearsall (knee, ankle) is considered questionable to play on Sunday against the hosting Philadelphia Eagles in a Wild-Card playoff game, according to Cam Inman of the Bay Area News Group. The questionable tag leaves the door open for Pearsall to play this weekend, but he's definitely on the wrong side of questionable after missing a full week of practice for the second straight week. The 25-year-old aggravated a PCL sprain in his knee that caused him to miss a big chunk of the regular season as well. Fantasy managers definitely shouldn't expect him to be active on Sunday. If Pearsall is officially out for a second straight game, Jauan Jennings should operate as the team's clear WR1, with both Demarcus Robinson and Kendrick Bourne filling bigger roles behind Jennings. Tight end George Kittle should also be heavily targeted.
January 9, 2026 4:57 PM EST
San Francisco 49ers tight end George Kittle (ankle) has been cleared from the final injury report and will play on Wild-Card weekend on Sunday against the Philadelphia Eagles, according to Cam Inman of the Bay Area News Group. Kittle missed Week 17 with a sprained ankle, but he returned to play 95% of the offensive snaps in the Week 18 regular-season finale against the Seattle Seahawks last Saturday. The expectation all along was that the 32-year-old veteran Pro Bowler would be good to go for the first round of the playoffs. The matchup isn't great -- the Eagles' defense allowed the second-fewest half-PPR points to opposing TEs this year -- but Kittle should still be considered one of the best options at the position in fantasy playoff formats. Kittle averaged 12.1 half-PPR points per game (third-most at TE) in his 11 regular-season contests.
January 9, 2026 4:51 PM EST
San Francisco 49ers wide receiver Kendrick Bourne recorded 37 receptions for 551 yards (14.89 YPC) and zero touchdowns on 53 targets in 16 games in 2025. The majority of Bourne's production came in early October, when he stepped in as the team's main pass-catcher, with George Kittle, Jauan Jennings, and Ricky Pearsall (knee, ankle) all ruled out for a brief time. Bourne's role faded as the team continued to get healthy; however, should Pearsall miss Sunday's contest against the Philadelphia Eagles, Bourne could find himself playing more often and would likely be elevated to the team's No. 2 wide receiver alongside Jennings. Additionally, according to Novig, the Niners are underdogs (+4.5) and should be in a game flow that favors a pass-happy approach, which would result in more target opportunities for Bourne should he get more playing time. Demarcus Robinson would likely be operating more in three-wide receiver sets. Pending Pearsall's availability, Bourne would be a bit of a dart throw in fantasy playoff leagues, but would be worth a roster as a long-shot option.
January 9, 2026 9:29 AM EST
San Francisco 49ers tight end George Kittle (ankle) was listed as a limited participant at practice again on Thursday, according to Cam Inman of the Bay Area News Group. Kittle missed Week 17 with an ankle injury, but he returned in the Week 18 regular-season finale against the Seattle Seahawks to play 95% of the offensive snaps. The entire San Fran offense struggled mightily last Saturday night, though, and Kittle caught five passes for only 29 yards on seven targets. Barring a setback on Friday, Kittle should be fine to play in the Wild-Card round of the playoffs on Sunday at the Philadelphia Eagles, where he should be heavily targeted with receiver Ricky Pearsall (knee, ankle) likely out. Kittle should be in play as one of the most expensive TEs in DFS action this weekend, even though the Eagles allowed the second-fewest half-PPR fantasy points per game to the position during the regular season.
January 8, 2026 5:57 PM EST
San Francisco 49ers wide receiver Ricky Pearsall (knee, ankle) was seen on a side field during Thursday's practice, according to Matt Barrows of The Athletic. Pearsall is going to go down as a non-participant in practice for the second straight day, which doesn't bode well for his availability on Sunday in the Wild-Card playoff game on the road against the Philadelphia Eagles. The 25-year-old missed six games earlier this year due to a PCL sprain in his right knee, and he aggravated the injury in Week 17. The former first-rounder did not play in the Week 18 regular-season finale against the Seattle Seahawks last Saturday and is on the wrong side of questionable to be active for the first round of the playoffs. If Pearsall misses Sunday's game, Jauan Jennings, Demarcus Robinson, and Kendrick Bourne could all see more targets in the passing game in a tough matchup against Philly's defense.
January 8, 2026 5:08 PM EST
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