These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of November 23, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers wide receiver Brandon Aiyuk (knee) continues to recover from last year's ACL injury, and NFL Network's Mike Garafolo reports that Aiyuk is "close to being cleared" for a return. The receiver's 21-day practice window hasn't been opened yet, but the 49ers remain hopeful that he'll get back on the field in the near future. San Francisco's receiving corps could use the help as Jauan Jennings and Ricky Pearsall have been underwhelming, combining for 53 catches, 705 yards, and three touchdowns while managing their respective injuries. Aiyuk could become an instant WR2 or WR3 in fantasy football upon his return, but an exact timetable for his activation remains unclear. This isn't the only news story we've seen about Aiyuk this week, though. A few days ago, Dianna Russini and Michael Silver of The Athletic reported that Aiyuk and the Niners were headed for a "stunning split" after the team voided his 2026 guarantees for a failure to meet contractual obligations, creating a clear path to his release next offseason. While Russini and Silver wrote that Aiyuk has likely played his final game for the 49ers, Garafolo's report seems to clarify that he'll have a good chance to get back on the field in 2025 before the team makes a decision on his future during the offseason.
November 23, 2025 11:55 AM EST
San Francisco 49ers kicker Eddy Pineiro (hamstring) has been ruled out ahead of the Week 12 matchup against the Carolina Panthers. This doesn't come as a surprise after Pineiro failed to practice at all this week. His absence will likely result in Matt Gay being elevated from the practice squad. He figures to serve as the kicker for at least one week with Pineiro having a chance to return in Week 13. Gay has spent most of the season with the Washington Commanders, making 13-of-19 field goal attempts. He has struggled this season, so there should be better streaming options out there ahead of Week 12.
November 22, 2025 6:13 PM EST
San Francisco 49ers tight end George Kittle finished Week 11 with six catches for 67 yards and two touchdowns on six targets. His production made him the second-highest scoring tight end in fantasy football for the second week in a row. Even with wide receiver Ricky Pearsall (knee) returning to the lineup, Kittle remained a priority target for quarterback Brock Purdy (toe). Kittle can keep the good times rolling in Week 12, when the 49ers face the Carolina Panthers on Monday Night Football. The Panthers have allowed the fourth-most receiving yards to tight ends this year and are seeing the highest average yards per target to the position. Kittle is one of the safer bets one can make on a tight end in fantasy football, and he should be locked into starting lineups for Week 12.
November 22, 2025 5:59 AM EST
San Francisco 49ers wide receiver Demarcus Robinson saw little change in his utilisation in the wake of Ricky Pearsall's (knee) return in Week 11. Robinson's snap share has hovered around 25% for most of the season, and that trend continued in the 49ers' 41-22 win over the Cardinals when Robinson checked in for 26% of the team's offensive snaps. Another trend that continued was his limited involvement when he was on the field, as he saw just one target that he caught for a 13-yard gain. Through eight games, Robinson now has 12 receptions for 155 yards and no touchdowns on 22 targets. Despite the 49ers' offense missing Pearsall, Jauan Jennings, and George Kittle for multiple weeks due to injuries, Robinson never found a way to make an impact. Now that all three are sharing the field, Robinson stands little chance of being a dependable fantasy contributor and is a risky bet in Week 12.
Demarcus Robinson player page.
November 22, 2025 5:55 AM EST
San Francisco 49ers wide receiver Kendrick Bourne took a big step back in the team's 41-22 dismantling of the Arizona Cardinals in Week 11. With Jauan Jennings and Ricky Pearsall (knee) both on the field for the first time since Week 4, Bourne's snap share went from 68% in Week 10 to 25% in Week 11. Bourne finished the game without a single target. Bourne was riding high after back-to-back 142-yard games in Weeks 5 and 6, when injuries to Jennings, Pearsall, and George Kittle forced him to the top of the pecking order in the 49ers' passing game. As his teammates have recovered and returned to action, Bourne has seen his role diminished and has just nine targets over the 49ers' last five games. At this point, Bourne is simply a depth piece for San Francisco and holds very little potential to help fantasy football teams in Week 12.
November 22, 2025 5:51 AM EST
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