These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 15, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers wide receiver Jauan Jennings (ankle) injured his ankle in the Week 2 win over the New Orleans Saints on Sunday and will be evaluated day-to-day through this week, according to David Lombardi of The Athletic. It's been one thing after another for Jennings health-wise since offseason workouts, when he suffered a calf injury. The 28-year-old missed most of training camp and all of the preseason after aggravating his calf issue before injuring his shoulder in the season-opening win over the Seattle Seahawks. The good news is that he looked healthy and operated as the WR1 on Sunday against the Saints, catching five of 10 targets for 89 yards and his first touchdown of 2025. Jennings will at least be in play as a WR4/flex if he's active in Week 3 against the division-rival Cardinals, but if he's out or limited, Ricky Pearsall would be the top target for quarterback Mac Jones.
September 15, 2025 6:50 PM EST
San Francisco 49ers wide receiver Jauan Jennings looked like his team's clear-cut WR1 in Week 2, hauling in five catches for 89 yards and a touchdown in a win over the New Orleans Saints. Jennings was targeted 10 times by 49ers quarterback Mac Jones, four more targets than any other San Francisco wideout. The 28-year-old has now logged seven catches for 105 yards and a score on the season, and that's with leaving Week 1 early due to a shoulder injury. As long as Jennings can stay on the field, he profiles as a solid fantasy WR3.
September 15, 2025 10:11 AM EST
San Francisco 49ers quarterback Mac Jones completed 26 of his 39 pass attempts for 279 yards, three touchdowns, and zero interceptions during Sunday's Week 2 win over the New Orleans Saints. He also rushed for six yards and took three sacks. Jones made the start on Sunday with Brock Purdy (shoulder) sidelined, and he looked very comfortable and productive. The former first-round pick will remain the team's starter for the duration of Purdy's absence, which will likely last several weeks. While Jones isn't a long-term solution for fantasy managers, he presents an intriguing option on the waiver wire ahead of Week 3. Next Sunday, the 49ers are set to take on the Arizona Cardinals, who just allowed 328 yards and three touchdowns to Bryce Young. With NFL starting experience and a variety of weapons at his disposal, Jones should put together another solid game against the subpar Cardinals defense. He should rank just outside the top 12 fantasy quarterbacks heading into next week, making him a worthwhile fill-in for managers dealing with injuries or underwhelming quarterback play.
September 15, 2025 12:40 AM EST
San Francisco 49ers running back Christian McCaffrey rushed for 55 yards on 13 carries during Sunday's Week 2 victory over the New Orleans Saints. He also caught six of seven targets for an additional 53 receiving yards and one receiving touchdown. Although the veteran playmaker didn't quite eclipse the 100-yard mark, he made up for it by scoring his first touchdown of the 2025 campaign. He also served as a very valuable and dependable pass-catching option for quarterback Mac Jones amidst the injury to Brock Purdy (shoulder). McCaffrey has wasted no time making a big impact in fantasy football, scoring at least 22.7 points (PPR) in each of his first two games this year. There's minimal competition for the 29-year-old in San Francisco, keeping him in the mid-range RB1 tier ahead of Week 3 versus the Arizona Cardinals.
Christian McCaffrey player page.
September 14, 2025 8:39 PM EST
San Francisco 49ers fullback Kyle Juszczyk (concussion) has been ruled out for the remainder of his team's Week 2 game against the New Orleans Saints. Juszczyk is a key piece of the San Francisco offense as both a blocker and receiver. The 49ers entered the game already without quarterback Brock Purdy (toe), tight end George Kittle (hamstring), and wide receiver Brandon Aiyuk (knee). Juszczyk's absence may create even more reason for San Francisco to get the ball in the hands of star running back Christian McCaffrey.
September 14, 2025 2:07 PM EST
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