These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 10, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 1.08 | 14 |
| 2 | George Kittle | TE | SF | 4.08 | 14 |
| 3 | Brock Purdy | QB | SF | 6.09 | 14 |
| 4 | Ricky Pearsall | WR | SF | 7.06 | 14 |
| 5 | Jauan Jennings | WR | SF | 7.09 | 14 |
| 6 | San Francisco Defense | DEF | SF | 12.08 | 14 |
| 7 | Brandon Aiyuk | WR | SF | 12.11 | 14 |
Christian McCaffrey's current ADP is 1.08, which is the 8th pick of the 1st round, and 8th selection overall.
George Kittle's current ADP is 4.08, which is the 8th pick of the 4th round, and 43rd selection overall.
Brock Purdy's current ADP is 6.09, which is the 9th pick of the 6th round, and 69th selection overall.
Ricky Pearsall's current ADP is 7.06, which is the 6th pick of the 7th round, and 78th selection overall.
Jauan Jennings's current ADP is 7.09, which is the 9th pick of the 7th round, and 81st selection overall.
San Francisco Defense's current ADP is 12.08, which is the 8th pick of the 12th round, and 139th selection overall.
Brandon Aiyuk's current ADP is 12.11, which is the 11th pick of the 12th round, and 143rd selection overall.
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers wide receiver Jauan Jennings (shoulder) is not participating in practice on Wednesday, according to Cam Inman of the Bay Area News Group. Jennings is dealing with a left-shoulder injury that isn't regarded as significant, but he's not a lock to play on Sunday against the New Orleans Saints. While Jennings caught just two of five targets for 16 yards in a win over the Seattle Seahawks in Week 1, going without him on Sunday would be another unwelcome development for the 49ers' wounded offense. The team placed standout tight end George Kittle (hamstring) on Injured Reserve earlier this week, and quarterback Brock Purdy (toe, shoulder) seems likely to sit out because of toe and shoulder issues. Even if Jennings is ready to go on Sunday, the fact that Mac Jones could start at QB won't do his fantasy stock any favors.
September 10, 2025 4:40 PM EST
San Francisco 49ers quarterback Brock Purdy (shoulder, toe) is "a long shot" to play on Sunday against the New Orleans Saints, head coach Kyle Shanahan told reporters. Purdy is dealing with injuries to his toe and left (non-throwing) shoulder, which could set the stage for Mac Jones to get his first start as a member of the 49ers. Jones, a former first-round pick from Alabama, picked up 49 starts in his first four seasons while playing with the New England Patriots and Jacksonville Jaguars. Aside from a promising first season, though, Jones has underwhelmed in the NFL. On paper, Jones and the 49ers will face a weak opponent in the Saints' defense, but the Niners' injury issues on offense go beyond Purdy. Tight end George Kittle (hamstring) and wide receiver Brandon Aiyuk (knee) won't play, while WRs Jauan Jennings (shoulder) and Jordan Watkins (ankle) are also among the team's banged-up players. Jones clearly won't be operating with a full complement of weapons if he does start.
September 10, 2025 4:15 PM EST
Additional scans on Tuesday on San Francisco 49ers wide receiver Jauan Jennings (shoulder) came back clean, and he has avoided a significant left-shoulder injury after he was injured in the Week 1 win over the Seattle Seahawks, a source told ESPN's Adam Schefter. The Niners are now considering Jennings day-to-day, and he will have a chance to play in Week 2 on Sunday against the New Orleans Saints. The 28-year-old missed all of the preseason and most of training camp with a calf injury while also holding out for a new contract. He proceeded to struggle with two catches on five targets for 16 yards in the season opener before getting hurt. Jennings should see an uptick in targets with tight end George Kittle (hamstring) on IR, but with quarterback Brock Purdy (shoulder, toe) up in the air for Week 2, he's trending as a very volatile flex play in fantasy this week.
September 9, 2025 6:13 PM EST
With the San Francisco 49ers placing All-Pro tight end George Kittle (hamstring) on the IR on Tuesday, the team is left with only Luke Farrell and Jake Tonges at the position. While fullback Kyle Juszczyk could be asked to handle an expanded role, it was the fourth-year tight end Tonges who stepped in on Sunday following Kittle's departure due to a hamstring injury. Tonges made the first three catches of his NFL career, including a 4-yard TD pass with under two minutes to play. With quarterback Brock Purdy (shoulder, toe) and wide receiver Jauan Jennings (shoulder) also banged up, the 49ers' offense may look entirely different heading into Week 2. While the gameplan will continue to be funneled directly through Christian McCaffrey, the team will be looking for contributions wherever they can get them, and Tonges could be in line for his first career start. While his effectiveness could be capped in a Mac Jones offense, desperate managers can throw a waiver dart in hopes of volume by necessity.
September 9, 2025 2:50 PM EST
According to Adam Schefter of ESPN, the San Francisco 49ers are placing tight end George Kittle (hamstring) on the injured reserve. As a result, Kittle will miss at least the next four games. The star tight end suffered this injury during their Week 1 victory over the Seattle Seahawks. Before exiting the contest, Kittle caught all four of his targets for 25 yards and a touchdown. When he was sidelined, Kittle was replaced by Luke Farrell and Jake Tonges. Fantasy managers should continue to monitor his status, but it appears he will be sidelined for at least the next month. While he remains out, fantasy managers should expect Farrell to see most of the blocking work while Tonges takes on most of the receiving work. Tonges caught all three of his targets for 15 yards and appears to be in the lead role to take on most of Kittle's offensive production. He is worth targeting in deep 14+ team formats on the waiver wire.
September 9, 2025 1:15 PM EST
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