These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of November 14, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
Across nine games played this season, San Francisco 49ers wide receiver Kendrick Bourne has hauled in 31 catches for 482 yards on 42 targets. The vast majority of Bourne's production came in a two-week stretch in early October, when he recorded 15 catches for 284 yards on 20 targets. The 49ers' pass-catching corps has gotten healthier in recent weeks thanks to the returns of wide receiver Jauan Jennings and tight end George Kittle, which has shrunk Bourne's role in the offense. Over his last two games played, Bourne has recorded three catches for 53 yards on three targets. Heading into their Week 11 matchup against the Arizona Cardinals, San Francisco will welcome wide receiver Ricky Pearsall (knee) back to the lineup for his first game since Week 4. Pearsall's return should only further limit Bourne's opportunities for playing time. Bourne should be off the radar of fantasy managers heading into Week 11.
November 14, 2025 11:00 AM EST
San Francisco 49ers head coach Kyle Shanahan said on Thursday that wide receiver Ricky Pearsall (knee) will return on Sunday to face the division-rival Arizona Cardinals in Week 11, according to KNBR. Pearsall finally returned to practice this week after spraining the PCL in his knee way back in Week 4, and he'll be back on the field this weekend as the Niners look to sweep the season series against Arizona. In addition to Pearsall, quarterback Brock Purdy (toe) will be back. Both players have been sidelined since Week 4. The banged-up 49ers are getting closer to full health on offense. Pearsall, a first-rounder in 2024, caught 20 of his 29 targets for 327 yards and no touchdowns in four games this year before injuring his knee. He will definitely be a starter in three-wide sets now that he's back, but he may be eased back into the offense, making him a shaky fantasy play in his first game back this weekend.
November 13, 2025 6:56 PM EST
San Francisco 49ers head coach Kyle Shanahan said on Thursday that quarterback Brock Purdy (toe) will return to the starting lineup this Sunday against the division-rival Arizona Cardinals in Week 11, according to Matt Maiocco of NBC Sports. Shanahan said earlier this week that Purdy would be practicing with the intention of starting this weekend, and it looks like that will happen. It will be just the third start of the year for the 25-year-old signal-caller, and the first since he aggravated his turf-toe injury in Week 4. Purdy is surely an upgrade over Mac Jones under center, although fantasy managers will have to weigh the potential rust factor after Purdy's long layoff. Still, in a plus matchup against Arizona's defense, Purdy should be in play immediately as a low-end QB1 option for fantasy managers who might be hurting at the position in Week 11. He's rostered in 59% of Yahoo leagues right now.
November 13, 2025 6:17 PM EST
San Francisco 49ers general manager John Lynch left open the possibility that wide receiver Brandon Aiyuk (knee) may not make it back to play at all in 2025, according to KNBR. "That's not the intention, the intention is to get Brandon back. We're not there yet, we just gotta get him to a place where we're comfortable opening that window, and see if he can make it back on the field. That is the intention. But we'll see, no absolutes there," Lynch said when asked if there was a scenario in which Aiyuk wouldn't make it back to play this year. The 27-year-old has been on the Physically Unable to Perform list all season after tearing his MCL and ACL in Week 7 of 2024. Head coach Kyle Shanahan said the team will not open Aiyuk's 21-day practice window this week, either, so he won't make his 2025 debut in Week 11 against the division-rival Cardinals. Fantasy managers still stashing Aiyuk may not want to get their hopes up.
November 13, 2025 12:17 PM EST
San Francisco 49ers wide receiver Ricky Pearsall (knee) is a receiver that could make an impact as the season progresses. After missing the last five games with a PCL injury, Pearsall returned to practice Wednesday alongside quarterback Brock Purdy, who's also been sidelined with a toe injury. With both players trending toward returning, fantasy managers should keep Pearsall on their radar. In his three full games this season, the rookie recorded 16 receptions on 24 targets for 281 yards, though he has yet to score a touchdown. With Brandon Aiyuk's return still uncertain, Pearsall carries WR2 potential and is a strong buy-low candidate in fantasy.
November 13, 2025 10:32 AM EST
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