These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of August 15, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 1.07 | 14 |
| 2 | George Kittle | TE | SF | 4.07 | 14 |
| 3 | Brock Purdy | QB | SF | 7.04 | 14 |
| 4 | Jauan Jennings | WR | SF | 7.04 | 14 |
| 5 | Ricky Pearsall | WR | SF | 8.11 | 14 |
| 6 | Brandon Aiyuk | WR | SF | 12.08 | 14 |
| 7 | Isaac Guerendo | RB | SF | 13.07 | 14 |
| 8 | San Francisco Defense | DEF | SF | 14.01 | 14 |
| 9 | Jake Moody | PK | SF | 14.12 | 14 |
Christian McCaffrey's current ADP is 1.07, which is the 7th pick of the 1st round, and 6th selection overall.
George Kittle's current ADP is 4.07, which is the 7th pick of the 4th round, and 43rd selection overall.
Brock Purdy's current ADP is 7.04, which is the 4th pick of the 7th round, and 75th selection overall.
Jauan Jennings's current ADP is 7.04, which is the 4th pick of the 7th round, and 75th selection overall.
Ricky Pearsall's current ADP is 8.11, which is the 11th pick of the 8th round, and 95th selection overall.
Brandon Aiyuk's current ADP is 12.08, which is the 8th pick of the 12th round, and 139th selection overall.
Isaac Guerendo's current ADP is 13.07, which is the 7th pick of the 13th round, and 151st selection overall.
San Francisco Defense's current ADP is 14.01, which is the 1st pick of the 14th round, and 157th selection overall.
Jake Moody's current ADP is 14.12, which is the 12th pick of the 14th round, and 167th selection overall.
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Home | New York Jets |
| 2 | Away | Minnesota Vikings |
| 3 | Away | Los Angeles Rams |
| 4 | Home | New England Patriots |
| 5 | Home | Arizona Cardinals |
| 6 | Away | Seattle Seahawks |
| 7 | Home | Kansas City Chiefs |
| 8 | Home | Dallas Cowboys |
| 10 | Away | Tampa Bay Buccaneers |
| 11 | Home | Seattle Seahawks |
| 12 | Away | Green Bay Packers |
| 13 | Away | Buffalo Bills |
| 14 | Home | Chicago Bears |
| 15 | Home | Los Angeles Rams |
| 16 | Away | Miami Dolphins |
| 17 | Home | Detroit Lions |
| 18 | Away | Arizona Cardinals |
San Francisco 49ers head coach Kyle Shanahan said that he expects to play quarterback Brock Purdy and some of the other starters in the team's second preseason contest this Saturday against the Las Vegas Raiders. Purdy did not play in the preseason opener last Saturday against the Denver Broncos, so this will be his preseason debut this year, although he probably won't play more than a couple offensive series. The 25-year-old still has low-end QB1 potential with Shanahan running the offense and running back Christian McCaffrey in the backfield, but it's also concerning that San Fran's receiving corps is so beat up right now -- Brandon Aiyuk (knee) is on the PUP list and Jauan Jenninngs (calf), Jacob Cowing (hamstring) and rookie Jordan Watkins (ankle) are all hurt. Purdy's rushing ability gives him a higher floor for fantasy, even if the Niners' offense doesn't fully bounce back.
August 14, 2025 5:52 PM EST
San Francisco 49ers wide receiver Jauan Jennings (calf) posted a photo on his social-media account of him getting treatment on Thursday morning from Las Vegas, where his teammates are scheduled to have a joint practice against the Las Vegas Raiders, according to Matt Maiocco of NBC Sports Bay Area. Jennings has not practiced with the team since the first week of training camp after aggravating a calf injury that he also dealt with during spring workouts. The 28-year-old is also in the midst of contract-extension negotiations with the organization, so he's in no rush to push himself back onto the field and risk further injury. Still, he's losing valuable reps with the first-team offense in a year in which he has a huge opportunity to be one of the team's top-targeted wideouts with Brandon Aiyuk (knee) hurt and Deebo Samuel Sr. no longer in town. Jennings is on the WR3/4 borderline as a fantasy sleeper in 2025.
August 14, 2025 2:14 PM EST
San Francisco 49ers wide receiver Jacob Cowing (hamstring) returned to practice on Tuesday, Nick Wagoner of ESPN reports. Cowing, who suffered a hamstring injury on the first day of camp, did individual work and mixed in some team snaps in his first practice back. The 5-foot-9, 171-pounder appeared in 15 games as a fourth-round rookie last year and caught a mere four passes for 80 yards. However, he garnered praise from head coach Kyle Shanahan during minicamp, and there was talk of Cowing helping to replace the departed Deebo Samuel Jr. in a gadget role. Now, there may be a path to more opportunities with the 49ers facing issues at the receiver position. Brandon Aiyuk (knee) will miss the first several weeks of the regular season, Jordan Watkins (ankle) is out for a month, and Jauan Jennings (calf) is also banged up. Additionally, Demarcus Robinson is staring at a potential suspension from a 2024 misdemeanor DUI charge.
August 12, 2025 8:32 PM EST
San Francisco 49ers wide receiver Jacob Cowing (hamstring) is expected to return to practice on Tuesday, according to David Lombardi of the SF Standard. Cowing has been nursing a hamstring injury that he suffered a few weeks ago, but he looks set to return to the practice field before the second preseason game. The 49ers receiver room has been dealing with multiple injuries, including Jauan Jennings, Brandon Aiyuk, and most recently, rookie Jordan Watkins. Cowing had an uneventful rookie season but had gaudy production during college and has an opportunity to emerge. He won't be on many fantasy radars in drafts, but he could be a name to keep in mind as the season gets closer.
August 12, 2025 12:35 AM EST
The San Francisco 49ers have placed running back Ameer Abdullah (ribs) on season-ending injured reserve, according to ESPN's Adam Schefter. Abdullah, who just joined the 49ers as a free agent on July 31, suffered a rib injury in a preseason-opening 30-9 loss to the Denver Broncos this past Saturday. While the 32-year-old was unlikely to make much of an impact this season (if any), it's another hit to San Francisco's depth in the backfield. The team is already set to go multiple weeks without injured Christian McCaffrey backups Isaac Guerendo (shoulder) and Jordan James (finger). The 49ers brought back Jeff Wilson Jr. in free agency on Sunday in the wake of Abdullah's injury to provide some much-needed healthy depth behind McCaffrey.
August 11, 2025 8:41 PM EST
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