These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 10, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 1.08 | 14 |
| 2 | George Kittle | TE | SF | 4.08 | 14 |
| 3 | Brock Purdy | QB | SF | 6.09 | 14 |
| 4 | Ricky Pearsall | WR | SF | 7.06 | 14 |
| 5 | Jauan Jennings | WR | SF | 7.09 | 14 |
| 6 | San Francisco Defense | DEF | SF | 12.08 | 14 |
| 7 | Brandon Aiyuk | WR | SF | 12.11 | 14 |
Christian McCaffrey's current ADP is 1.08, which is the 8th pick of the 1st round, and 8th selection overall.
George Kittle's current ADP is 4.08, which is the 8th pick of the 4th round, and 43rd selection overall.
Brock Purdy's current ADP is 6.09, which is the 9th pick of the 6th round, and 69th selection overall.
Ricky Pearsall's current ADP is 7.06, which is the 6th pick of the 7th round, and 78th selection overall.
Jauan Jennings's current ADP is 7.09, which is the 9th pick of the 7th round, and 81st selection overall.
San Francisco Defense's current ADP is 12.08, which is the 8th pick of the 12th round, and 139th selection overall.
Brandon Aiyuk's current ADP is 12.11, which is the 11th pick of the 12th round, and 143rd selection overall.
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers quarterback Brock Purdy suffered a stinger on the team's final offensive play during Saturday's Week 18 loss against the Seattle Seahawks, according to head coach Kyle Shanahan (via Ian Rapoport of NFL.com). Purdy took a hit while throwing an incomplete pass late in the fourth quarter. He remained down on the field and received medical attention for a brief period of time, but he was able to stand up and walk off the field under his own power. After the loss, Shanahan said that Purdy was okay and could have gone back into the game if San Francisco got the ball back. This bodes well for Purdy's status heading into Wild Card Weekend. Barring a setback, we expect him to suit up. The 49ers' first-round opponent will be decided when games go final on Sunday in Week 18. San Francisco will be either the No. 5 or No. 6 seed.
January 4, 2026 7:38 AM EST
San Francisco 49ers tight end George Kittle (ankle) is active ahead of Saturday's Week 18 matchup versus the Seattle Seahawks. Kittle is back in action this week after sitting out in Week 17 due to an ankle sprain. The expectation is that Kittle will have a full workload despite being limited in practice this week. Kittle is expected to see a larger target share with wide receiver Ricky Pearsall (ankle, knee) ruled out for Saturday's game. The 32-year-old is a must-start and is ranked second among all tight ends behind only Trey McBride in the latest RotoBaller rankings for Week 18.
January 3, 2026 6:59 PM EST
San Francisco 49ers wide receiver Ricky Pearsall (knee, ankle) is officially inactive ahead of Saturday's Week 18 matchup versus the Seattle Seahawks. Pearsall was questionable coming into this game, but will sit out due to an ankle sprain and a PCL injury. The absence of Pearsall should mean increased looks for Jauan Jennings and George Kittle. There's a chance that Demarcus Robinson and Kendrick Bourne see a larger target share, but they remain inconsistent options. Jennings and Kittle are the best DFS options with Pearsall sidelined for the regular season finale.
January 3, 2026 6:47 PM EST
San Francisco 49ers quarterback Brock Purdy enters Week 18 on an absolute heater. Over his last three games, the 26-year-old has thrown for 893 yards, 11 touchdowns, and two interceptions. However, Purdy will face a difficult matchup in Week 18 against the Seattle Seahawks. Seattle enters the week ranked first among NFL defenses in yards per pass attempt allowed (6.1) and ninth in passing touchdowns allowed (20). Making matters even tougher, Purdy could be without star left tackle Trent Williams (hamstring), whose status for Week 18 is unclear due to a hamstring injury. Still, the 49ers offense is firing on all cylinders, as the team is averaging 42.3 points per game over its last three contests. Purdy will also get back star tight end George Kittle, who missed Week 17 due to an ankle injury. Fantasy managers should have some reason to be concerned about the matchup for Purdy in Week 18. However, given how well he has played lately, Purdy remains a solid fantasy QB1 against Seattle.
January 3, 2026 12:41 PM EST
San Francisco 49ers tight end Jake Tonges had a big game in Week 17, recording seven catches for 60 yards and a touchdown on nine targets. Tonges benefited from the absence of star 49ers tight end George Kittle (ankle), who was sidelined by an ankle injury. Across the six games Kittle has missed this season, Tonges has racked up 29 catches for 269 yards and three touchdowns on 40 targets. However, recent reporting indicates that Kittle is trending towards returning for the 49ers' Week 18 matchup against the Seattle Seahawks. Tonges has been far less productive across the 10 games where Kittle has been active in 2025, hauling in five receptions for 24 yards and two scores on just six targets. If Kittle is indeed active for Week 18, Tonges should be avoided by fantasy managers.
January 2, 2026 10:41 AM EST
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