These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of November 7, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers wide receiver Ricky Pearsall (knee) has been running, but he hasn't quite been cleared to make his return after spraining his PCL in the Week 4 loss to the Jacksonville Jaguars, according to Cam Inman of the Bay Area News Group. "He can run and hit certain speeds. But he hasn't been able to hit his normal speeds that would allow him to come back. We're waiting until he hits his markers," head coach Kyle Shanahan said. Pearsall was officially ruled out for Week 10 this Sunday against the division-rival Los Angeles Rams, his sixth straight absence. The 25-year-old was a popular breakout candidate during training camp and the preseason this year, with Brandon Aiyuk (knee) recovering from a torn ACL and MCL, but injury issues of his own have limited him to just four games, and he's running out of time to make an impact for his fantasy managers. Pearsall must get back on the practice field next week to have a chance at playing in Week 11 against the Arizona Cardinals.
November 7, 2025 7:19 PM EST
San Francisco 49ers quarterback Brock Purdy (toe) is officially listed as questionable for the Week 10 game this Sunday against the division-rival Los Angeles Rams, according to Cam Inman of the Bay Area News Group. Inman also reports that Mac Jones will make his eighth start of the year, so if Purdy is active this weekend, it will be in a backup role. The 25-year-old Purdy has yet to practice in full since aggravating a turf-toe injury back in the Week 4 loss to the Jacksonville Jaguars, so he won't be given the starting gig back just yet. Purdy is getting closer to playing just his third game of the year, but it's unclear if he'll be back to face the division-rival Arizona Cardinals in Week 11. Fantasy managers who have been stashing him this entire time may be running out of patience, but it's been made clear he's the Niners' starter under center when he's past his turf-toe injury. In his two games played this year, Purdy has gone 48-for-73 passing for 586 yards, four touchdowns, and four interceptions.
November 7, 2025 5:44 PM EST
The disappointing season continues for San Francisco 49ers wide receiver Ricky Pearsall (knee), as he was officially ruled out for the Week 10 contest on Sunday versus the division-rival Los Angeles Rams, according to Cam Inman of the Bay Area News Group. Pearsall hasn't practiced since suffering a PCL sprain in his knee in the Week 4 loss to the Jacksonville Jaguars and will now miss a sixth straight game. The 25-year-old former first-rounder has quickly developed a reputation as being injury-prone and a slow healer. It's unclear if he'll have a chance to make his return in the Week 11 divisional matchup against the Arizona Cardinals, but Pearsall will have to first get back on the practice field. Jauan Jennings and Kendrick Bourne will continue to serve as the team's top two receivers this weekend, with quarterback Mac Jones likely to make another start in place of the injured Brock Purdy (toe).
November 7, 2025 5:38 PM EST
San Francisco 49ers fourth-year tight end Jake Tonges filled in admirably while teammate George Kittle missed five games with a hamstring injury. However, since Kittle's return, Tonges has seen a total of 16 offensive snaps over the past three weeks. And while he did catch a two-yard touchdown in Week 8, it came on his lone target over that same timeframe. While Kittle has yet to top 4 targets or 45 yards since returning, Tonges no longer appears to have any role in this offense and can confidently be dropped by the select few fantasy managers who might still be holding him. Kittle remains an every-week starter, while the hope remains that the eventual return of quarterback Brock Purdy will put him right back into the weekly TE1 conversation.
November 7, 2025 3:01 PM EST
San Francisco 49ers head coach Kyle Shanahan said on Thursday that quarterback Brock Purdy (toe) is "getting closer to returning," according to Clayton Holloway of NFL Network. The 49ers will decide on Friday whether or not Purdy will play on Sunday against the division-rival Los Angeles Rams in Week 10. "Yeah, pretty confident we'll see him this year," Shanahan said when asked if he's confident that Purdy will play again this season. The 25-year-old was limited in practice again on Thursday. He will need to upgrade to a full practice on Friday to play this weekend for the first time since aggravating a turf-toe injury in the Week 4 loss to the Jacksonville Jaguars. Purdy has only played in two games in 2025, so there will certainly be a rust factor to think about in fantasy if he's able to return this Sunday against a formidable Rams defense. It seems as though the Niners are leaning toward giving Mac Jones his eighth start of the year.
November 6, 2025 7:23 PM EST
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