San Francisco
49ers
49ers Top Fantasy Players
These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 25, 2026.
| # | Name | Pos | Team | ADP | Bye |
|---|
San Francisco 49ers 2025 Schedule
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers News
Brandin Cooks, Brandin Cooks to Have Role in Week 4 Given 49ers Injuries
San Francisco 49ers wide receiver Brandin Cooks is expected to make his debut in Week 4 against the Denver Broncos. Cooks signed with the 49ers' practice squad, was promoted to the active roster on Thursday, and is set to play Sunday. The veteran receiver played 15 games with the New Orleans Saints and the Buffalo Bills last season, hauling in 24 of 36 targets for 279 yards and no touchdowns. With Mike Evans (ribs) questionable and De'Zhaun Stribling (ankle), Christian Kirk (calf), and Demarcus Robinson on injured reserve, Cooks will likely slot in alongside Deebo Samuel Sr., Jordan Watson, and Jacob Cowing. While he faces a difficult test against the Broncos' stout secondary, Cooks could be a receiver to watch if he has success in Week 4.
October 3, 2026 8:24 AM EST
Jacob Cowing, Jacob Cowing Could Benefit for 49ers Injuries in Week 4
San Francisco 49ers wide receiver Jacob Cowing should see an expanded role in Week 4, with several injuries across the team's wide receiver room. Although Cowing hasn't recorded a stat in three games this season, he's seen increased usage over the past two weeks. He's played 36% of snaps and 36% of routes. Wide receiver Mike Evans (ribs) is questionable, and De'Zhaun Stribling (ankle), Christian Kirk (calf), and Demarcus Robinson are on injured reserve. If Evans can't play, Cowing should be a key contributor alongside Deebo Samuel Sr. and Jordan Watkins. They face a difficult matchup against the Denver Broncos, who have allowed the 10th-fewest fantasy points to wide receivers this season and the second-fewest in 2025. Fantasy managers in deeper leagues should keep tabs on Cowing, especially if the 49ers suffer additional injuries to their already depleted receiver room.
October 3, 2026 8:16 AM EST
Eddy Piñeiro, Eddy Pineiro Looking To Rebound In Week 4
San Francisco 49ers kicker Eddy Pineiro whiffed on two extra point attempts in Week 3 but converted his other three tries and nailed a 57-yard field goal, his only attempt of the game. Never quite known for being a powerful kicker before coming to San Francisco last season, Pineiro is now 8-for-10 from 50-plus yards in 17 games with the team, compared to 11-for-14 in his 70 previous games with other teams going back to 2019. The 49ers' high-powered offense has given Pineiro the lead in extra point attempts through three weeks with 13, though it has cost him opportunities to attempt field goals. Pineiro could be in for a more productive game in Week 4, in what is expected to be a high-scoring affair with the Denver Broncos. Pineiro is projected as a top-10 option this week and is worthy of a start in fantasy football lineups.
October 3, 2026 12:44 AM EST
George Kittle, George Kittle A Top Option In Week 4
San Francisco 49ers tight end George Kittle put any lingering concerns about his Achilles to bed with his performance in Week 3. Kittle played a big role in the 49ers' 36-30 win, catching six of his seven targets for 82 receiving yards and two fourth-quarter touchdowns. Kittle is the most likely candidate to emerge as Brock Purdy's primary target in Week 4, as injuries to San Francisco's wide receiver corps keep piling up. Mike Evans (ribs) is listed as questionable and is considered a game-time decision. His absence would afford Kittle a few extra looks. In Week 4, San Francisco hosts the Denver Broncos, who gave up eight receptions for 62 yards and a touchdown to the Rams' Tyler Higbee last week. In PPR scoring, Kittle is the overall TE5 and is averaging 15.8 fantasy points per game. He is projected as a top-five tight end for Week 4, and should be in starting lineups this weekend.
October 3, 2026 12:31 AM EST
Deebo Samuel Sr., Deebo Samuel Sr. Could Benefit From Teammates' Injuries
San Francisco 49ers wide receiver Deebo Samuel Sr. made history in Week 3 with his 80-yard touchdown off a lateral from Mike Evans (ribs). Samuel finished that game without receiving a pass from quarterback Brock Purdy, which gave him the dubious honor of having the most receiving yards without a catch in an NFL game. Samuel wasn't even targeted in the game, but he should be more involved in Week 4 against the Broncos, with Mike Evans (ribs) a game-time decision and Demarcus Robinson (ankle) joining De'Zhaun Stribling (ankle) and Christian Kirk (calf) on injured reserve. On paper, Samuel's matchup is not easy, but last week the Rams were able to exploit Denver's secondary to the tune of 390 passing yards. Samuel is projected as a WR3 in Week 4. His explosive play ability and potential for increased involvement in the 49ers' offense make him worth starting on Sunday.
October 3, 2026 12:21 AM EST
