These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of November 28, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers kicker Eddy Pineiro (hamstring) did not practice all week and has been ruled out for the Week 13 contest against the hosting Cleveland Browns this Sunday, according to The Athletic's Zac Jackson. Pineiro will miss another game with a right-hamstring injury. Matt Gay will kick for the team for the second straight week. The 31-year-old veteran made both of his field-goal attempts and both of his extra points in his debut with the Niners in their Monday night win over the Carolina Panthers in Week 12. Inclement weather is scheduled for Cleveland on Sunday, so fantasy managers may want to steer clear of Gay as a streaming option at the kicker position. The 49ers have their bye in Week 14, so Pineiro might be ready to roll when the team returns to action on Sunday, Dec. 14, versus the Tennessee Titans in Week 15.
November 28, 2025 7:14 PM EST
Since returning from the knee injury that caused him to miss six games, San Francisco 49ers wide receiver Ricky Pearsall has caught three passes in his last two outings for only six yards. In leagues without an IR spot, Pearsall was a frustrating hold on the hopes that he would reignite his early-season success immediately upon return. His 281 receiving yards through the first three weeks of the season trailed only OPOY candidate Jaxon Smith-Njigba, but as he eases his way closer to a full workload, his involvement over the past two games has made him unplayable. It should be noted that George Kittle left early in the season opener with a hamstring injury, clearing a path to the promising WR1 workload for Pearsall. However, with a healthy Kittle playing in both games since his return, Pearsall has been out-targeted by the All-Pro tight end 15-to-6. The 49ers face a stingy Cleveland defense in Week 13 before a Week 14 bye, making Pearsall one of the league's bigger question marks heading into the fantasy playoffs.
November 28, 2025 3:06 PM EST
San Francisco 49ers kicker Eddy Pineiro (hamstring) was a non-participant during Wednesday's practice session. Pineiro wasn't able to practice at all last week before eventually getting ruled out for the Week 12 matchup against the Carolina Panthers. It's not looking good as Pineiro is sidelined to begin this week as well. He's currently considered week-to-week due to a Grade 1 hamstring strain. In his absence, Matt Gay was perfect on all four of his kick attempts. Gay figures to get another start if Pineiro is sidelined versus the Cleveland Browns in Week 13.
November 26, 2025 8:17 PM EST
The San Francisco 49ers will not open the 21-day practice window for wide receiver Brandon Aiyuk (knee) this week, according to head coach Kyle Shanahan. The same goes for fellow wideout Jacob Cowing (hamstring). A report surfaced last week that the 49ers voided guarantees in Aiyuk's four-year contract extension, which could lead to the 27-year-old former first-rounder sitting out the entire 2025 campaign. If that happens, the 49ers would likely release him at season's end. Fantasy managers who have been stashing Aiyuk all season long might not get to use him at all. It's good news for the rest-of-season outlooks for both Jauan Jennings and Ricky Pearsall, as well as tight end George Kittle. Aiyuk has been recovering from his season-ending injury last year, in which he tore both his ACL and MCL.
November 26, 2025 3:44 PM EST
NFL Network's Tom Pelissero reports that the NFL will review San Francisco 49ers wide receiver Jauan Jennings' actions on Monday night against the Carolina Panthers for a possible fine, but he won't be suspended. Panthers safety Tre'Von Moehrig took a cheap shot to a sensitive area for Jennings late in Monday night's game, and Jennings had to be held back following the conclusion of the contest. The 28-year-old caught five of his seven targets for 41 yards and his fourth touchdown of the season in the 20-9 victory. Three of Jennings' four scores on the year have come in the last four games, and he has a higher fantasy ceiling with quarterback Brock Purdy recovered from a turf-toe injury that caused him to miss most of the season. Going into a tough Week 13 matchup against the Cleveland Browns, Jennings should be viewed as a touchdown-dependent WR3/flex option.
November 25, 2025 3:57 PM EST
Copyright 2025 Fantasy Football Calculator | Image Source: Icon Sportswire. Not affiliated with the National Football League (NFL).
Stats powered by FantasyData.com.
