These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of November 27, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers kicker Eddy Pineiro (hamstring) was a non-participant during Wednesday's practice session. Pineiro wasn't able to practice at all last week before eventually getting ruled out for the Week 12 matchup against the Carolina Panthers. It's not looking good as Pineiro is sidelined to begin this week as well. He's currently considered week-to-week due to a Grade 1 hamstring strain. In his absence, Matt Gay was perfect on all four of his kick attempts. Gay figures to get another start if Pineiro is sidelined versus the Cleveland Browns in Week 13.
November 26, 2025 8:17 PM EST
The San Francisco 49ers will not open the 21-day practice window for wide receiver Brandon Aiyuk (knee) this week, according to head coach Kyle Shanahan. The same goes for fellow wideout Jacob Cowing (hamstring). A report surfaced last week that the 49ers voided guarantees in Aiyuk's four-year contract extension, which could lead to the 27-year-old former first-rounder sitting out the entire 2025 campaign. If that happens, the 49ers would likely release him at season's end. Fantasy managers who have been stashing Aiyuk all season long might not get to use him at all. It's good news for the rest-of-season outlooks for both Jauan Jennings and Ricky Pearsall, as well as tight end George Kittle. Aiyuk has been recovering from his season-ending injury last year, in which he tore both his ACL and MCL.
November 26, 2025 3:44 PM EST
NFL Network's Tom Pelissero reports that the NFL will review San Francisco 49ers wide receiver Jauan Jennings' actions on Monday night against the Carolina Panthers for a possible fine, but he won't be suspended. Panthers safety Tre'Von Moehrig took a cheap shot to a sensitive area for Jennings late in Monday night's game, and Jennings had to be held back following the conclusion of the contest. The 28-year-old caught five of his seven targets for 41 yards and his fourth touchdown of the season in the 20-9 victory. Three of Jennings' four scores on the year have come in the last four games, and he has a higher fantasy ceiling with quarterback Brock Purdy recovered from a turf-toe injury that caused him to miss most of the season. Going into a tough Week 13 matchup against the Cleveland Browns, Jennings should be viewed as a touchdown-dependent WR3/flex option.
November 25, 2025 3:57 PM EST
San Francisco 49ers quarterback Brock Purdy (toe) went 23-for-32 for 193 yards, one touchdown, and three interceptions in Monday's 20-9 win over the Carolina Panthers. He also had 16 rushing yards on six carries. Purdy struggled to connect with his receivers on intermediate and deep routes, completing just one of his eight attempts of 10 yards or more. All three of his interceptions came on shots 20 yards downfield or longer. In postgame comments, Purdy insisted his picks had nothing to do with the turf toe injury that has cost him eight games this season. The 49ers will travel to Cleveland in Week 13 to face the Browns, whose defense has allowed the third-fewest passing yards and owns the highest sack rate in the league. Purdy projects as a QB2 against that stout defense in what will be a cold-weather game.
November 25, 2025 10:47 AM EST
San Francisco 49ers tight end George Kittle totaled six receptions for 78 yards on 10 targets in a Monday night win over the Carolina Panthers. Kittle led the 49ers in both targets and receiving yards in the win. Outside of zero catch performance in his first game returning from his early-season hamstring injury in Week 7 against the Falcons, the superstar tight end has been as advertised as an early-round pick for fantasy managers. In the other five games, including Monday night, he's racked up 29 catches for 304 yards and four touchdowns on 34 targets, good for an average of 16.6 PPR points per game. The 32-year-old will again profile as a top-three tight end option in Week 13 against the Cleveland Browns.
November 25, 2025 12:43 AM EST
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