San Francisco
49ers
49ers Top Fantasy Players
These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 25, 2026.
| # | Name | Pos | Team | ADP | Bye |
|---|
San Francisco 49ers 2025 Schedule
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers News
Brandon Aiyuk, No Resolution in Sight for Brandon Aiyuk
San Francisco 49ers wide receiver Brandon Aiyuk remains on the reserve/left squad list, and there's no indication that he'll be returning to play anytime soon. Aiyuk missed most of 2024 and all of 2025 while recovering from numerous knee injuries. He's healthy again this year, but some off-the-field antics prompted the 49ers to commit to never playing him again. At the same time, there seems to have been minimal trade interest in the veteran receiver. It wouldn't have been crazy to assume that a couple of receiver-needy teams made calls for Aiyuk, but there's no indication that has happened. Instead, Aiyuk remains off the field, perhaps making it difficult for him to get back up to full speed once he does play again. The 28-year-old has minimal value in dynasty leagues right now, so managers in many leagues could justify dropping him to waivers.
October 10, 2026 7:39 AM EST
Brandin Cooks, Brandin Cooks a Riskier Week 5 Play Despite Veteran Status
San Francisco 49ers wide receiver Brandin Cooks should be active for Week 5 against the Seattle Seahawks, given the number of injuries plaguing the rest of the receiver room. As a result, he is starting to warrant some consideration as a low-end flex option in fantasy football. The Niners are marching into this divisional battle shorthanded on both sides of the ball, but perhaps no position group has been impacted by injuries more than the wide receivers. With Mike Evans (ribs) questionable and De'Zhaun Stribling (ankle), Christian Kirk (calf), and Demarcus Robinson (ankle) all sidelined, the 49ers will turn to a group of Cooks, Deebo Samuel Sr., and Jacob Cowing to step up. Evans played through his rib injury last week, keeping Cooks and Cowing off the fantasy radar. However, if the veteran receiver isn't able to play on Sunday, we could see one of Cooks or Cowing possess some flex appeal alongside Samuel. Cooks can be left on waivers for now, but he's not a bad streamer once the inactives are announced and we know whether Evans will be playing.
October 10, 2026 7:35 AM EST
Eddy Piñeiro, Eddy Pineiro A Solid Choice In Week 5
San Francisco 49ers kicker Eddy Pineiro was 3-for-3 on his extra points, converted one field goal attempt, and had another one blocked in last Sunday's win over the Denver Broncos. Pineiro's make from the field was on a 24-yarder in the second quarter. The block came on a 54-yard try at the end of the first half. He is 14-for-16 on extra points, leading the league in both conversions and attempts, and 4-for-6 on field goal attempts. San Francisco's ability to convert drives into touchdowns has robbed Pineiro of more opportunities to try the field goals that would be more lucrative for fantasy purposes. However, it bodes well for his prospects that his offense can consistently drive into their opponent's territory. In Week 5, Pineiro is worth starting in what should be a hard-fought divisional matchup between the 49ers and Seattle Seahawks.
October 10, 2026 3:05 AM EST
George Kittle, George Kittle Remains Top Option Against Seattle
San Francisco 49ers tight end George Kittle's playmaking in Week 4 served as another reason for fantasy managers to no longer worry about the Achilles injury that he suffered in last season's playoffs. Late in the fourth quarter, Kittle caught a pass underneath and then carved his way through Broncos defenders for a 56-yard touchdown, putting the game out of reach. It was his fourth touchdown in the last three weeks and gave him his third consecutive top-10 finish at his position in fantasy football. Kittle and the 49ers have a divisional matchup against the Seattle Seahawks on tap for Week 5. Seattle's defense is among the best in the league, but in Week 2 the Cardinals found a way to get Trey McBride eight catches and a touchdown. San Francisco will need to keep Kittle involved to compete with the Seahawks on Sunday. Despite the challenging matchup, Kittle is a must-start.
October 10, 2026 2:50 AM EST
Deebo Samuel Sr., Deebo Samuel Sr. Still A Flex Option Against Tough Defense
San Francisco 49ers wide receiver Deebo Samuel Sr. found the end zone again in last week's win over the Denver Broncos, giving him three touchdowns in the first four games of the season. Samuel's versatility has been on display in recent weeks, first being the recipient of a hook-and-ladder toss that he took 80 yards to the house in Week 3, and seeing increased use in the backfield in Week 4, resulting in three carries for 44 rushing yards. In Week 5, the 49ers are facing their stiffest challenge of the season in the Seattle Seahawks. Seattle has held opposing wide receivers to a league-low 395 receiving yards and has given up just 16.8 points per game through four weeks. Samuel will be schemed into the divisional matchup, but he still sits behind Christian McCaffrey, George Kittle, and Mike Evans in the pecking order. He can be started in fantasy football in Week 5 as a WR3/flex option.
October 10, 2026 2:22 AM EST
