These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 10, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 1.08 | 14 |
| 2 | George Kittle | TE | SF | 4.08 | 14 |
| 3 | Brock Purdy | QB | SF | 6.09 | 14 |
| 4 | Ricky Pearsall | WR | SF | 7.06 | 14 |
| 5 | Jauan Jennings | WR | SF | 7.09 | 14 |
| 6 | San Francisco Defense | DEF | SF | 12.08 | 14 |
| 7 | Brandon Aiyuk | WR | SF | 12.11 | 14 |
Christian McCaffrey's current ADP is 1.08, which is the 8th pick of the 1st round, and 8th selection overall.
George Kittle's current ADP is 4.08, which is the 8th pick of the 4th round, and 43rd selection overall.
Brock Purdy's current ADP is 6.09, which is the 9th pick of the 6th round, and 69th selection overall.
Ricky Pearsall's current ADP is 7.06, which is the 6th pick of the 7th round, and 78th selection overall.
Jauan Jennings's current ADP is 7.09, which is the 9th pick of the 7th round, and 81st selection overall.
San Francisco Defense's current ADP is 12.08, which is the 8th pick of the 12th round, and 139th selection overall.
Brandon Aiyuk's current ADP is 12.11, which is the 11th pick of the 12th round, and 143rd selection overall.
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
The San Francisco 49ers will open the 21-day practice window for wide receiver Jacob Cowing (hamstring) this week, according to Matt Maiocco of NBC Sports Bay Area. Cowing will practice with the team on Wednesday, according to head coach Kyle Shanahan. The 24-year-old is getting closer to returning from Injured Reserve, but he could still be unlikely to be activated to play in the Wild-Card playoff game this Sunday against the hosting Philadelphia Eagles. If Cowing does end up playing against the Eagles, he will most likely only have a role on special teams after missing the entire 2025 regular season. The former fourth-round selection in 2024 out of Arizona caught four of his six targets for 80 yards in 15 games last year in his first season in the NFL. Cowing will be a long shot to surface as an option in playoff fantasy formats.
January 5, 2026 7:45 PM EST
San Francisco 49ers quarterback Brock Purdy (neck) "checked out good" after suffering a stinger on the final play of the game on Saturday night in the Week 18 loss to the Seattle Seahawks and should be full-go for Wild-Card weekend on Sunday versus the Philadelphia Eagles, according to David Lombardi of The San Francisco Standard. Head coach Kyle Shanahan said that he expects Purdy to practice in full this week and play on Sunday in Philly. The 26-year-old finished the year strong for his fantasy managers with 11 touchdown passes and just two interceptions in Weeks 15-18, but he was shut down by Seattle last weekend and threw for just 127 yards with no touchdowns and one interception. Purdy played in only nine games in 2025 due to a turf-toe injury, but he was incredibly efficient when on the field. He'll have another tough challenge on his hands in the first round of the playoffs against an Eagles defense that allowed the second-fewest fantasy points per game to QBs over the final five weeks.
January 5, 2026 3:32 PM EST
San Francisco 49ers head coach Kyle Shanahan said that wide receiver Ricky Pearsall (knee) aggravated his PCL injury last week, which is why he was inactive for the Week 18 loss to the Seattle Seahawks on Saturday night despite practicing all week before the game, according to David Lombardi of The San Francisco Standard. The 25-year-old former first-rounder is also dealing with an ankle sprain, which makes him questionable to play in the Wild-Card round of the playoffs this Sunday versus the hosting Philadelphia Eagles. When healthy, Pearsall is one of quarterback Brock Purdy's top targets, but he's played in just nine games in 2025 due to injuries after playing in 11 games in his rookie campaign. If Pearsall misses a second straight game this weekend, Jauan Jennings, Demarcus Robinson, and Kendrick Bourne would all be in line for more targets.
January 5, 2026 3:25 PM EST
San Francisco 49ers quarterback Brock Purdy suffered a stinger on the team's final offensive play during Saturday's Week 18 loss against the Seattle Seahawks, according to head coach Kyle Shanahan (via Ian Rapoport of NFL.com). Purdy took a hit while throwing an incomplete pass late in the fourth quarter. He remained down on the field and received medical attention for a brief period of time, but he was able to stand up and walk off the field under his own power. After the loss, Shanahan said that Purdy was okay and could have gone back into the game if San Francisco got the ball back. This bodes well for Purdy's status heading into Wild Card Weekend. Barring a setback, we expect him to suit up. The 49ers' first-round opponent will be decided when games go final on Sunday in Week 18. San Francisco will be either the No. 5 or No. 6 seed.
January 4, 2026 7:38 AM EST
San Francisco 49ers tight end George Kittle (ankle) is active ahead of Saturday's Week 18 matchup versus the Seattle Seahawks. Kittle is back in action this week after sitting out in Week 17 due to an ankle sprain. The expectation is that Kittle will have a full workload despite being limited in practice this week. Kittle is expected to see a larger target share with wide receiver Ricky Pearsall (ankle, knee) ruled out for Saturday's game. The 32-year-old is a must-start and is ranked second among all tight ends behind only Trey McBride in the latest RotoBaller rankings for Week 18.
January 3, 2026 6:59 PM EST
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