These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of October 6, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
As San Francisco 49ers quarterback Brock Purdy (toe) continues to deal with a turf toe injury that has now kept him out of three games, Backup Mac Jones has stepped in admirably, prompting some to wonder if a quarterback controversy could be brewing in the Bay Area. Appearing on the Pat McAfee Show on Monday, NFL Insider Adam Schefter was quick to dismiss the idea. Purdy and the 49ers agreed to a five-year contract extension before the start of the season that keeps him tied to the team through 2030. So while Jones has been impressive in running Kyle Shanahan's offense and saying the right things along the way, Schefter does not believe there's any threat of him maintaining the job once Purdy returns to health.
October 6, 2025 3:11 PM EST
San Francisco 49ers wide receiver Kendrick Bourne stepped up in a big way for the banged-up 49ers in their 26-23 win over the Los Angeles Rams on Thursday night, catching a whopping 10 passes on 11 targets for a career-best 142 receiving yards. Bourne was a cutdown-day casualty in New England with the Patriots after training camp, but he latched on quickly with San Francisco and has been a big addition because of injuries to both Jauan Jennings and Ricky Pearsall. The 30-year-old veteran was quarterback Mac Jones' most reliable and productive target as the Niners pulled off the upset on the road at SoFi Stadium. "KB's been awesome for us, man," head coach Shanahan said. Seven of Bourne's 10 grabs came in the second half. Bourne and Jones clearly have chemistry, but Bourne's fantasy value moving forward will all depend on when Jennings and Pearsall return to action.
October 6, 2025 12:28 PM EST
San Francisco 49ers tight end George Kittle (hamstring) has been on Injured Reserve since suffering a hamstring injury in Week 1 and is first eligible to return in Week 6 against the Tampa Bay Buccaneers. However, that appears doubtful, as 49ers head coach Kyle Shanahan said Kittle is a "long shot" to return in Week 6 and that a Week 7 return against the Atlanta Falcons is more likely. In Kittle's absence, San Francisco tight end Jake Tonges has recorded 19 catches for 166 yards and three touchdowns, including 10 catches for 99 yards and two scores in his last two games. If Kittle is indeed sidelined for Week 6, Tonges could be a low-end starting option for fantasy managers at the tight end position.
October 3, 2025 3:49 PM EST
NFL Insider Ian Rapoport reported on Thursday Night Football that San Francisco 49ers wide receiver Brandon Aiyuk (knee), coming off a significant knee injury, is "still weeks away" from returning. Aiyuk was placed on the PUP list to start the season, which required him to miss at least the first four games of the year. It appears he will miss more time, with an uncertain timetable for his return. Fantasy managers who have the room to continue to hold him on their IR should, but with the number of injuries that have transpired over the last two weeks, fantasy managers who need to make room on their team for players closer to returning might want to consider that, as Aiyuk is looking like he won't return anytime in the next few weeks.
October 3, 2025 9:46 AM EST
San Francisco 49ers tight end Jake Tonges caught seven of his 11 targets for 41 yards and a touchdown during Thursday's win over the Los Angeles Rams. Tonges has filled in quite admirably for George Kittle (hamstring), who could return as early as next week. Through five games, the 26-year-old has 19 catches, 166 yards, and three touchdowns, ranking 10th among tight ends in fantasy points per game. The return of Kittle, whether that happens sooner or later, will push Tonges back to a depth role and keep him off the fantasy radar. At the moment, it's too early to predict whether Kittle will return and impact Tonges' fantasy outlook next week against the Ravens.
October 3, 2025 12:53 AM EST
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