These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 10, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 1.08 | 14 |
| 2 | George Kittle | TE | SF | 4.08 | 14 |
| 3 | Brock Purdy | QB | SF | 6.09 | 14 |
| 4 | Ricky Pearsall | WR | SF | 7.06 | 14 |
| 5 | Jauan Jennings | WR | SF | 7.09 | 14 |
| 6 | San Francisco Defense | DEF | SF | 12.08 | 14 |
| 7 | Brandon Aiyuk | WR | SF | 12.11 | 14 |
Christian McCaffrey's current ADP is 1.08, which is the 8th pick of the 1st round, and 8th selection overall.
George Kittle's current ADP is 4.08, which is the 8th pick of the 4th round, and 43rd selection overall.
Brock Purdy's current ADP is 6.09, which is the 9th pick of the 6th round, and 69th selection overall.
Ricky Pearsall's current ADP is 7.06, which is the 6th pick of the 7th round, and 78th selection overall.
Jauan Jennings's current ADP is 7.09, which is the 9th pick of the 7th round, and 81st selection overall.
San Francisco Defense's current ADP is 12.08, which is the 8th pick of the 12th round, and 139th selection overall.
Brandon Aiyuk's current ADP is 12.11, which is the 11th pick of the 12th round, and 143rd selection overall.
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers running back Jordan James is active for Monday's Week 16 contest against the Indianapolis Colts and is on track to make his NFL debut. The rookie had previously been a healthy scratch, but he's getting a chance to play on primetime television, perhaps in a mix of special teams and offensive depth roles. He's taking the spot of fellow rookie Isaac Guerendo, who is a healthy scratch for the first time in his young career. Guerendo has contributed on special teams this year, but he doesn't have an offensive snap yet. Both running backs remain buried on the depth chart behind Christian McCaffrey and Brian Robinson Jr.
December 22, 2025 7:11 PM EST
San Francisco 49ers wide receiver Ricky Pearsall (knee, ankle) has been ruled out for the Week 16 matchup against the Indianapolis Colts. Pearsall was unable to practice all week due to knee and ankle injuries he suffered during last week's win over the Tennessee Titans. He'll miss at least one game, but will hopefully return for the Week 17 matchup against the Chicago Bears. The absence of Pearsall should mean larger roles for Jauan Jennings, Kendrick Bourne, and Demarcus Robinson. Out of the three, Jennings is the only consistent fantasy option heading into the Monday Night matchup versus the Colts.
December 20, 2025 6:17 PM EST
San Francisco 49ers wide receiver Ricky Pearsall (knee, ankle) missed practice for the third straight day on Saturday and is considered unlikely to play Monday night against the Indianapolis Colts, Matt Barrows of The Athletic reports. Pearsall aggravated his PCL injury during last week's win over the Tennessee Titans and is set to miss more time. The second-year wideout still produced a strong receiving line despite picking up the injury, catching six of seven targets for 96 yards. Jauan Jennings should be in line to see an uptick in opportunities behind Christian McCaffrey and George Kittle in San Francisco's pass game on Monday night, with Kendrick Bourne also in line to fill in for extra reps.
December 20, 2025 4:21 PM EST
San Francisco 49ers kicker Eddy Pineiro returned to action in Week 15 after missing two games due to a hamstring injury. Pineiro was money against the Titans, nailing every one of his attempts in the game. Pineiro was 3-for-3 on field goals, with makes from 33, 37, and 40 yards out, and was 4-for-4 on extra points. He has missed four PATs in 2025, but remains perfect on field goal tries. In Week 16, Pineiro has the benefit of playing inside a dome when the 49ers travel to Indianapolis to face the Colts. Over the last four weeks, the Colts have allowed more fantasy points per game (12.8) to opposing kickers than any team in the NFL. Pineiro makes for a solid choice in Week 16.
December 20, 2025 11:39 AM EST
San Francisco 49ers wide receiver Kendrick Bourne slipped behind Demarcus Robinson on the depth chart in recent weeks, but reclaimed the WR3 role against the Titans in Week 15. Robinson did end the game with more receiving yards, but Bourne logged a higher snap share between the two for the first time since Week 10. Ricky Pearsall (knee/ankle) missed the first two practices of Week 16 after aggravating his PCL injury last week. If Pearsall is unavailable, then Bourne is presumed to be the next man in line to fill in for him, though that may not amount to much in fantasy value. Pearsall's six-catch, 96-yard game last week aside, quarterback Brock Purdy's main focus has been getting the ball to Christian McCaffrey, Jauan Jennings, or George Kittle. Bourne is a desperation flex at best, and only if Pearsall is out for Monday's game against the Colts.
December 20, 2025 6:14 AM EST
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