These are the top fantasy football players of the San Francisco 49ers as ranked by Average Draft Position (ADP) in PPR-format mock drafts.
Data as of September 10, 2025.
| # | Name | Pos | Team | ADP | Bye |
|---|---|---|---|---|---|
| 1 | Christian McCaffrey | RB | SF | 1.08 | 14 |
| 2 | George Kittle | TE | SF | 4.08 | 14 |
| 3 | Brock Purdy | QB | SF | 6.09 | 14 |
| 4 | Ricky Pearsall | WR | SF | 7.06 | 14 |
| 5 | Jauan Jennings | WR | SF | 7.09 | 14 |
| 6 | San Francisco Defense | DEF | SF | 12.08 | 14 |
| 7 | Brandon Aiyuk | WR | SF | 12.11 | 14 |
Christian McCaffrey's current ADP is 1.08, which is the 8th pick of the 1st round, and 8th selection overall.
George Kittle's current ADP is 4.08, which is the 8th pick of the 4th round, and 43rd selection overall.
Brock Purdy's current ADP is 6.09, which is the 9th pick of the 6th round, and 69th selection overall.
Ricky Pearsall's current ADP is 7.06, which is the 6th pick of the 7th round, and 78th selection overall.
Jauan Jennings's current ADP is 7.09, which is the 9th pick of the 7th round, and 81st selection overall.
San Francisco Defense's current ADP is 12.08, which is the 8th pick of the 12th round, and 139th selection overall.
Brandon Aiyuk's current ADP is 12.11, which is the 11th pick of the 12th round, and 143rd selection overall.
| Week | Home/Away | Opponent |
|---|---|---|
| 1 | Away | Seattle Seahawks |
| 2 | Away | New Orleans Saints |
| 3 | Home | Arizona Cardinals |
| 4 | Home | Jacksonville Jaguars |
| 5 | Away | Los Angeles Rams |
| 6 | Away | Tampa Bay Buccaneers |
| 7 | Home | Atlanta Falcons |
| 8 | Away | Houston Texans |
| 9 | Away | New York Giants |
| 10 | Home | Los Angeles Rams |
| 11 | Away | Arizona Cardinals |
| 12 | Home | Carolina Panthers |
| 13 | Away | Cleveland Browns |
| 15 | Home | Tennessee Titans |
| 16 | Away | Indianapolis Colts |
| 17 | Home | Chicago Bears |
| 18 | Home | Seattle Seahawks |
San Francisco 49ers tight end George Kittle (ankle) will be a limited participant in Wednesday's practice, according to Nick Wagoner of ESPN. Kittle suffered an ankle injury in Week 16 and was held out of Week 17, but the 32-year-old Pro Bowler made his return for the Week 18 regular-season finale showdown against the Seattle Seahawks last Saturday night. He tied for the team lead in targets in the loss, catching five of his seven targets for only 29 yards in a game in which the Niners couldn't find the end zone at all. Kittle should be fine to play on Sunday in the Wild-Card playoff tilt against the hosting Philadelphia Eagles, and he'll have a good chance to bounce back if receiver Ricky Pearsall (knee, ankle) misses a second straight game. Despite missing time with various lower-body injuries in 2025, Kittle averaged 12.1 half-PPR fantasy points per game. He should be one of the top TE targets for fantasy managers competing in playoff leagues this week.
January 7, 2026 3:18 PM EST
San Francisco 49ers wide receiver Ricky Pearsall (knee, ankle) will not practice on Wednesday, according to head coach Kyle Shanahan. Pearsall aggravated a PCL sprain in his right knee and was held out of the Week 18 regular-season finale against the Seattle Seahawks last Saturday. The 25-year-old former first-rounder missed a good chunk of the 2025 season due to his knee injury, so he could be fighting an uphill battle to play on Wild-Card weekend in Philadelphia against the Eagles on Sunday. If Pearsall cannot get cleared to play in the opening round of the playoffs, it will open up targets for receivers Jauan Jennings, Demarcus Robinson, and Kendrick Bourne, as well as tight end George Kittle. In the Week 18 loss to Seattle, Jennings led the team with four catches for only 35 yards. As of right now, Pearsall is likely on the wrong side of questionable to play against Philly.
January 7, 2026 3:07 PM EST
San Francisco 49ers running back Christian McCaffrey finished 2025 as the RB1 in almost all fantasy formats, and he carries the same projection into most fantasy playoff leagues. San Francisco opens the playoffs against the defending champion Philadelphia Eagles and a defensive front that scarcely resembles the one that gave Patrick Mahomes and the Chiefs fits in Super Bowl LIX. The Eagles were the 10th most generous fantasy defense to opposing running backs, and McCaffrey comes into the matchup having finished as the RB12 or better in 14 of 17 starts in Full-PPR formats. He is RotoBaller's RB1 for Wild Card Weekend and, given San Francisco's status as 4.5-point road underdogs, an obvious must-start in formats that allow players to be started only once.
Christian McCaffrey player page.
January 7, 2026 3:00 PM EST
The San Francisco 49ers will open the 21-day practice window for wide receiver Jacob Cowing (hamstring) this week, according to Matt Maiocco of NBC Sports Bay Area. Cowing will practice with the team on Wednesday, according to head coach Kyle Shanahan. The 24-year-old is getting closer to returning from Injured Reserve, but he could still be unlikely to be activated to play in the Wild-Card playoff game this Sunday against the hosting Philadelphia Eagles. If Cowing does end up playing against the Eagles, he will most likely only have a role on special teams after missing the entire 2025 regular season. The former fourth-round selection in 2024 out of Arizona caught four of his six targets for 80 yards in 15 games last year in his first season in the NFL. Cowing will be a long shot to surface as an option in playoff fantasy formats.
January 5, 2026 7:45 PM EST
San Francisco 49ers quarterback Brock Purdy (neck) "checked out good" after suffering a stinger on the final play of the game on Saturday night in the Week 18 loss to the Seattle Seahawks and should be full-go for Wild-Card weekend on Sunday versus the Philadelphia Eagles, according to David Lombardi of The San Francisco Standard. Head coach Kyle Shanahan said that he expects Purdy to practice in full this week and play on Sunday in Philly. The 26-year-old finished the year strong for his fantasy managers with 11 touchdown passes and just two interceptions in Weeks 15-18, but he was shut down by Seattle last weekend and threw for just 127 yards with no touchdowns and one interception. Purdy played in only nine games in 2025 due to a turf-toe injury, but he was incredibly efficient when on the field. He'll have another tough challenge on his hands in the first round of the playoffs against an Eagles defense that allowed the second-fewest fantasy points per game to QBs over the final five weeks.
January 5, 2026 3:32 PM EST
Copyright 2025 Fantasy Football Calculator | Image Source: Icon Sportswire. Not affiliated with the National Football League (NFL).
Stats powered by FantasyData.com.
