Saquon Barkley – New York Giants
Another premier star landing an injury, Saquon Barkley suffered a high ankle sprain in Week 3. After a Monday MRI, most peg Barkley for a 4-8-week absence. However, Barkley reportedly sought a second opinion, hoping for good news. Either way, Barkley looks likely to miss multiple weeks here, thrusting Wayne Gallman into the starting running back role in New York.